(28 nodes) (2021) Viral and Bacterial Co-Infections in the Lungs: Dangerous Liaisons. network (Mustela putorius)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	CD4	CD4. (462 aa)
	SOCS6	Suppressor of cytokine signaling 6. (586 aa)
	IL15	Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
	IFNLR1	Interferon lambda receptor 1. (515 aa)
	CCL2	C-C motif chemokine. (101 aa)
	OCLN	Occludin. (521 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (210 aa)
	STAT1	Signal transducer and activator of transcription. (750 aa)
	NLRP3	NLR family pyrin domain containing 3. (1035 aa)
	TNF	Tumor necrosis factor alpha; Belongs to the tumor necrosis factor family. (233 aa)
	TLR3	Toll like receptor 3; Belongs to the Toll-like receptor family. (764 aa)
	IL1B	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (168 aa)
	IL13	Interleukin 13. (128 aa)
	IL10	Interleukin 10. (220 aa)
	CD47	CD47 molecule. (306 aa)
	CXCL8	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
	IRF7	Interferon regulatory factor 7. (473 aa)
	CXCL10	C-X-C motif chemokine. (98 aa)
	IL18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
	TLR7	Toll like receptor 7; Belongs to the Toll-like receptor family. (1083 aa)
	IRF3	Interferon regulatory factor 3. (421 aa)
	TLR4	Toll like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
	STAT2	Signal transducer and activator of transcription. (848 aa)
	IFNB1	Interferon beta. (186 aa)
	TLR2	Toll like receptor 2; Belongs to the Toll-like receptor family. (785 aa)
	PTAFR	Platelet activating factor receptor; Belongs to the G-protein coupled receptor 1 family. (344 aa)
	TLR5	Toll like receptor 5; Belongs to the Toll-like receptor family. (858 aa)
	IL22	Interleukin 22. (178 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCL2	CD4	ENSMPUP00000014730	ENSMPUP00000016704	C-C motif chemokine.	CD4.	0.715
CCL2	CXCL10	ENSMPUP00000014730	ENSMPUP00000008619	C-C motif chemokine.	C-X-C motif chemokine.	0.896
CCL2	CXCL8	ENSMPUP00000014730	ENSMPUP00000009143	C-C motif chemokine.	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family.	0.533
CCL2	IFNB1	ENSMPUP00000014730	ENSMPUP00000019400	C-C motif chemokine.	Interferon beta.	0.538
CCL2	IL10	ENSMPUP00000014730	ENSMPUP00000009891	C-C motif chemokine.	Interleukin 10.	0.838
CCL2	IL13	ENSMPUP00000014730	ENSMPUP00000010430	C-C motif chemokine.	Interleukin 13.	0.658
CCL2	IL15	ENSMPUP00000014730	ENSMPUP00000015989	C-C motif chemokine.	Interleukin; Belongs to the IL-15/IL-21 family.	0.658
CCL2	IL18	ENSMPUP00000014730	ENSMPUP00000003649	C-C motif chemokine.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.690
CCL2	IL1B	ENSMPUP00000014730	ENSMPUP00000010696	C-C motif chemokine.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.844
CCL2	IL22	ENSMPUP00000014730	ENSMPUP00000017399	C-C motif chemokine.	Interleukin 22.	0.443
CCL2	IL6	ENSMPUP00000014730	ENSMPUP00000013489	C-C motif chemokine.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.908
CCL2	IRF3	ENSMPUP00000014730	ENSMPUP00000002449	C-C motif chemokine.	Interferon regulatory factor 3.	0.487
CCL2	IRF7	ENSMPUP00000014730	ENSMPUP00000008775	C-C motif chemokine.	Interferon regulatory factor 7.	0.561
CCL2	STAT1	ENSMPUP00000014730	ENSMPUP00000012436	C-C motif chemokine.	Signal transducer and activator of transcription.	0.583
CCL2	TLR2	ENSMPUP00000014730	ENSMPUP00000018774	C-C motif chemokine.	Toll like receptor 2; Belongs to the Toll-like receptor family.	0.591
CCL2	TLR3	ENSMPUP00000014730	ENSMPUP00000011144	C-C motif chemokine.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.585
CCL2	TLR4	ENSMPUP00000014730	ENSMPUP00000001697	C-C motif chemokine.	Toll like receptor 4; Belongs to the Toll-like receptor family.	0.679
CCL2	TLR7	ENSMPUP00000014730	ENSMPUP00000002534	C-C motif chemokine.	Toll like receptor 7; Belongs to the Toll-like receptor family.	0.459
CCL2	TNF	ENSMPUP00000014730	ENSMPUP00000011297	C-C motif chemokine.	Tumor necrosis factor alpha; Belongs to the tumor necrosis factor family.	0.854
CD4	CCL2	ENSMPUP00000016704	ENSMPUP00000014730	CD4.	C-C motif chemokine.	0.715