STRINGSTRING
CASP8 CASP8 IRAK4 IRAK4 JAK1 JAK1 LVRN LVRN TLR4 TLR4 CTSB CTSB HEY1 HEY1 IRF3 IRF3 TLR7 TLR7 TLR8 TLR8 TRAF3 TRAF3 ACE2 ACE2 MYD88 MYD88 SFTPD SFTPD IL18 IL18 ADAM10 ADAM10 ERAP1 ERAP1 ERAP2 ERAP2 JAK2 JAK2 REL REL TRADD TRADD IRF9 IRF9 JAG1 JAG1 CCR6 CCR6 TIRAP TIRAP TYK2 TYK2 ICAM1 ICAM1 DLL1 DLL1 BIRC2 BIRC2 ENPEP ENPEP CXCL10 CXCL10 DLL4 DLL4 TMPRSS2 TMPRSS2 IRF7 IRF7 IRAK1 IRAK1 FOS FOS PARG PARG IL9 IL9 IL10 IL10 MAPKAPK2 MAPKAPK2 IL7 IL7 NOX4 NOX4 IL4 IL4 STAT3 STAT3 IL1B IL1B TRAF2 TRAF2 TLR3 TLR3 POGLUT2 POGLUT2 NOTCH1 NOTCH1 LTB LTB TNF TNF RNASEL RNASEL RELA RELA REN REN TRAF6 TRAF6 TLR1 TLR1 SOCS1 SOCS1 SOCS3 SOCS3 IFNB1 IFNB1 TLR2 TLR2 EGFR EGFR BCL2L1 BCL2L1 POFUT1 POFUT1 DLL3 DLL3 CD40 CD40 TBK1 TBK1 CPM CPM ELF4 ELF4 IL2 IL2 IRAK2 IRAK2 TNFRSF1A TNFRSF1A CD4 CD4 BCL2 BCL2 TNFRSF1B TNFRSF1B IL15 IL15 ANPEP ANPEP FURIN FURIN TSC2 TSC2 NPEPPS NPEPPS RICTOR RICTOR IL6 IL6 ADAM17 ADAM17 STAT1 STAT1 VCAM1 VCAM1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CASP8Caspase 8; Belongs to the peptidase C14A family. (484 aa)
IRAK4Interleukin-1 receptor-associated kinase 4. (460 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
LVRNAminopeptidase. (992 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
CTSBCathepsin B; Belongs to the peptidase C1 family. (339 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
IRF3Interferon regulatory factor 3. (421 aa)
TLR7Toll like receptor 7; Belongs to the Toll-like receptor family. (1083 aa)
TLR8Toll like receptor 8; Belongs to the Toll-like receptor family. (1087 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (569 aa)
ACE2Angiotensin-converting enzyme. (805 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
SFTPDSurfactant protein D. (375 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
ADAM10ADAM metallopeptidase domain 10. (737 aa)
ERAP1Aminopeptidase. (942 aa)
ERAP2Aminopeptidase. (952 aa)
JAK2Tyrosine-protein kinase. (1130 aa)
RELREL proto-oncogene, NF-kB subunit. (594 aa)
TRADDTNFRSF1A associated via death domain. (314 aa)
IRF9Interferon regulatory factor 9. (416 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
CCR6C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (375 aa)
TIRAPTIR domain containing adaptor protein. (227 aa)
TYK2Tyrosine-protein kinase. (1182 aa)
ICAM1Intercellular adhesion molecule 1. (589 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (602 aa)
BIRC2Baculoviral IAP repeat containing 2. (570 aa)
ENPEPAminopeptidase. (946 aa)
CXCL10C-X-C motif chemokine. (98 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
TMPRSS2Transmembrane serine protease 2; Belongs to the peptidase S1 family. (531 aa)
IRF7Interferon regulatory factor 7. (473 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (696 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (446 aa)
PARGPoly(ADP-ribose) glycohydrolase. (977 aa)
IL9Interleukin 9. (143 aa)
IL10Interleukin 10. (220 aa)
MAPKAPK2MAPK activated protein kinase 2. (319 aa)
IL7Interleukin 7. (158 aa)
NOX4NADPH oxidase 4. (578 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (132 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (168 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (569 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (764 aa)
POGLUT2Protein O-glucosyltransferase 2. (502 aa)
NOTCH1Notch receptor 1. (2119 aa)
LTBLymphotoxin beta; Belongs to the tumor necrosis factor family. (247 aa)
TNFTumor necrosis factor alpha; Belongs to the tumor necrosis factor family. (233 aa)
RNASELRibonuclease L. (726 aa)
RELARELA proto-oncogene, NF-kB subunit. (511 aa)
RENRenin; Belongs to the peptidase A1 family. (404 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
TLR1Toll like receptor 1; Belongs to the Toll-like receptor family. (786 aa)
SOCS1Suppressor of cytokine signaling 1. (216 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
IFNB1Interferon beta. (186 aa)
TLR2Toll like receptor 2; Belongs to the Toll-like receptor family. (785 aa)
EGFRReceptor protein-tyrosine kinase. (1207 aa)
BCL2L1BCL2 like 1. (233 aa)
POFUT1Protein O-fucosyltransferase 1. (391 aa)
DLL3Delta like canonical Notch ligand 3. (590 aa)
CD40CD40 molecule. (277 aa)
TBK1TANK-binding kinase 1. (729 aa)
CPMCarboxypeptidase M. (443 aa)
ELF4E74 like ETS transcription factor 4. (661 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (152 aa)
IRAK2Interleukin 1 receptor associated kinase 2. (580 aa)
TNFRSF1ATNF receptor superfamily member 1A. (501 aa)
CD4CD4. (462 aa)
BCL2BCL2 apoptosis regulator. (207 aa)
TNFRSF1BTNF receptor superfamily member 1B. (509 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
ANPEPAminopeptidase. (980 aa)
FURINFurin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (796 aa)
TSC2TSC complex subunit 2. (1906 aa)
NPEPPSAminopeptidase. (860 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1732 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (210 aa)
ADAM17ADAM metallopeptidase domain 17. (822 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
VCAM1Vascular cell adhesion molecule 1. (739 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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