(6 nodes) (2022) RdRp inhibitors and COVID-19: Is molnupiravir a good option? network (Mustela putorius)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ACE	Angiotensin-converting enzyme. (1247 aa)
	TMPRSS2	Transmembrane serine protease 2; Belongs to the peptidase S1 family. (531 aa)
	IL10	Interleukin 10. (220 aa)
	TNF	Tumor necrosis factor alpha; Belongs to the tumor necrosis factor family. (233 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (210 aa)
	FURIN	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (796 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACE	IL6	ENSMPUP00000014859	ENSMPUP00000013489	Angiotensin-converting enzyme.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.411
ACE	TMPRSS2	ENSMPUP00000014859	ENSMPUP00000008734	Angiotensin-converting enzyme.	Transmembrane serine protease 2; Belongs to the peptidase S1 family.	0.472
FURIN	TMPRSS2	ENSMPUP00000015551	ENSMPUP00000008734	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	Transmembrane serine protease 2; Belongs to the peptidase S1 family.	0.773
FURIN	TNF	ENSMPUP00000015551	ENSMPUP00000011297	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	Tumor necrosis factor alpha; Belongs to the tumor necrosis factor family.	0.439
IL10	IL6	ENSMPUP00000009891	ENSMPUP00000013489	Interleukin 10.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.995
IL10	TNF	ENSMPUP00000009891	ENSMPUP00000011297	Interleukin 10.	Tumor necrosis factor alpha; Belongs to the tumor necrosis factor family.	0.936
IL6	ACE	ENSMPUP00000013489	ENSMPUP00000014859	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	Angiotensin-converting enzyme.	0.411
IL6	IL10	ENSMPUP00000013489	ENSMPUP00000009891	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	Interleukin 10.	0.995
IL6	TMPRSS2	ENSMPUP00000013489	ENSMPUP00000008734	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	Transmembrane serine protease 2; Belongs to the peptidase S1 family.	0.533
IL6	TNF	ENSMPUP00000013489	ENSMPUP00000011297	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	Tumor necrosis factor alpha; Belongs to the tumor necrosis factor family.	0.905
TMPRSS2	ACE	ENSMPUP00000008734	ENSMPUP00000014859	Transmembrane serine protease 2; Belongs to the peptidase S1 family.	Angiotensin-converting enzyme.	0.472
TMPRSS2	FURIN	ENSMPUP00000008734	ENSMPUP00000015551	Transmembrane serine protease 2; Belongs to the peptidase S1 family.	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	0.773
TMPRSS2	IL6	ENSMPUP00000008734	ENSMPUP00000013489	Transmembrane serine protease 2; Belongs to the peptidase S1 family.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.533
TNF	FURIN	ENSMPUP00000011297	ENSMPUP00000015551	Tumor necrosis factor alpha; Belongs to the tumor necrosis factor family.	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	0.439
TNF	IL10	ENSMPUP00000011297	ENSMPUP00000009891	Tumor necrosis factor alpha; Belongs to the tumor necrosis factor family.	Interleukin 10.	0.936
TNF	IL6	ENSMPUP00000011297	ENSMPUP00000013489	Tumor necrosis factor alpha; Belongs to the tumor necrosis factor family.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.905