STRINGSTRING
FURIN FURIN DPP4 DPP4 IFNAR1 IFNAR1 CCL20 CCL20 STAT2 STAT2 TLR4 TLR4 CTSB CTSB IRF3 IRF3 TLR7 TLR7 TLR8 TLR8 ACE2 ACE2 MYD88 MYD88 IL18 IL18 ZBTB16 ZBTB16 REXO2 REXO2 CADM1 CADM1 DPP9 DPP9 TICAM1 TICAM1 TYK2 TYK2 IL1RN IL1RN IL10 IL10 HDAC2 HDAC2 CTSC CTSC IL4 IL4 IRF1 IRF1 IL1B IL1B KDM5B KDM5B TLR3 TLR3 DDR1 DDR1 REN REN STAT1 STAT1 IL6 IL6 TLL1 TLL1 M3YU28_MUSPF M3YU28_MUSPF CCL5 CCL5 ACE ACE CCR2 CCR2 CCR5 CCR5 CCR9 CCR9 SLC6A20 SLC6A20 TBK1 TBK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FURINFurin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (796 aa)
DPP4Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. (765 aa)
IFNAR1Interferon alpha and beta receptor subunit 1. (560 aa)
CCL20C-C motif chemokine. (97 aa)
STAT2Signal transducer and activator of transcription. (848 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
CTSBCathepsin B; Belongs to the peptidase C1 family. (339 aa)
IRF3Interferon regulatory factor 3. (421 aa)
TLR7Toll like receptor 7; Belongs to the Toll-like receptor family. (1083 aa)
TLR8Toll like receptor 8; Belongs to the Toll-like receptor family. (1087 aa)
ACE2Angiotensin-converting enzyme. (805 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
ZBTB16Zinc finger and BTB domain containing 16. (673 aa)
REXO2RNA exonuclease 2. (237 aa)
CADM1Cell adhesion molecule 1. (427 aa)
DPP9Dipeptidyl peptidase 9; Belongs to the peptidase S9B family. (891 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (689 aa)
TYK2Tyrosine-protein kinase. (1182 aa)
IL1RNInterleukin-1. (158 aa)
IL10Interleukin 10. (220 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (469 aa)
CTSCCathepsin C; Belongs to the peptidase C1 family. (463 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (132 aa)
IRF1Interferon regulatory factor. (322 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (168 aa)
KDM5BLysine demethylase 5B. (1691 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (764 aa)
DDR1Discoidin domain receptor tyrosine kinase 1. (919 aa)
RENRenin; Belongs to the peptidase A1 family. (404 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (210 aa)
TLL1Metalloendopeptidase. (963 aa)
M3YU28_MUSPFAngiotensin-converting enzyme. (753 aa)
CCL5C-C motif chemokine. (91 aa)
ACEAngiotensin-converting enzyme. (1247 aa)
CCR2C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (337 aa)
CCR5C-C motif chemokine receptor 5 (gene/pseudogene); Belongs to the G-protein coupled receptor 1 family. (352 aa)
CCR9C-C motif chemokine receptor 9; Belongs to the G-protein coupled receptor 1 family. (365 aa)
SLC6A20Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (592 aa)
TBK1TANK-binding kinase 1. (729 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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