(51 nodes) (2022) The effect of the probiotic consortia on SARS-CoV-2 infection in ferrets and on human immune cell response in vitro. network (Mustela putorius)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

Your Input:
	IFNB1	Interferon beta. (186 aa)
	CD36	CD36 molecule; Belongs to the CD36 family. (472 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (152 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (333 aa)
	IL15	Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
	ISG20	Interferon stimulated exonuclease gene 20. (171 aa)
	CCR2	C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (337 aa)
	ACE	Angiotensin-converting enzyme. (1247 aa)
	CCL5	C-C motif chemokine. (91 aa)
	CCL2	C-C motif chemokine. (101 aa)
	ISG15	ISG15 ubiquitin like modifier. (184 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (210 aa)
	STAT1	Signal transducer and activator of transcription. (750 aa)
	TNF	Tumor necrosis factor alpha; Belongs to the tumor necrosis factor family. (233 aa)
	TLR3	Toll like receptor 3; Belongs to the Toll-like receptor family. (764 aa)
	IL1B	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (168 aa)
	IL4	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (132 aa)
	IL7	Interleukin 7. (158 aa)
	IL10	Interleukin 10. (220 aa)
	IL1A	Interleukin-1; Belongs to the IL-1 family. (270 aa)
	IL36G	Interleukin-1. (156 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (971 aa)
	TMPRSS2	Transmembrane serine protease 2; Belongs to the peptidase S1 family. (531 aa)
	MX1	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (670 aa)
	MX2	MX dynamin like GTPase 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (717 aa)
	CXCL9	C-X-C motif chemokine. (155 aa)
	CXCL10	C-X-C motif chemokine. (98 aa)
	CXCL11	C-X-C motif chemokine. (132 aa)
	CD80	CD80 molecule. (302 aa)
	CTRL	Chymotrypsin like; Belongs to the peptidase S1 family. (268 aa)
	IRF9	Interferon regulatory factor 9. (416 aa)
	NRP1	Neuropilin; Belongs to the neuropilin family. (923 aa)
	CD274	CD274 molecule. (303 aa)
	PDCD1LG2	Programmed cell death 1 ligand 2. (272 aa)
	CD86	CD86 molecule. (330 aa)
	CCL17	C-C motif chemokine. (99 aa)
	CX3CL1	C-X3-C motif chemokine ligand 1. (461 aa)
	CCL22	C-C motif chemokine. (93 aa)
	IL18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
	TLR8	Toll like receptor 8; Belongs to the Toll-like receptor family. (1087 aa)
	TLR7	Toll like receptor 7; Belongs to the Toll-like receptor family. (1083 aa)
	OAS2	2'-5'-oligoadenylate synthetase 2. (685 aa)
	OAS3	2'-5'-oligoadenylate synthetase 3. (1230 aa)
	OAS1	2'-5'-oligoadenylate synthetase 1. (400 aa)
	IRF3	Interferon regulatory factor 3. (421 aa)
	RPS18	Ribosomal protein S18; Belongs to the universal ribosomal protein uS13 family. (152 aa)
	STAT2	Signal transducer and activator of transcription. (848 aa)
	CD83	CD83 molecule. (199 aa)
	TNFAIP6	TNF alpha induced protein 6. (277 aa)
	CCR5	C-C motif chemokine receptor 5 (gene/pseudogene); Belongs to the G-protein coupled receptor 1 family. (352 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACE	IL2	ENSMPUP00000014859	ENSMPUP00000017283	Angiotensin-converting enzyme.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.503
ACE	IL6	ENSMPUP00000014859	ENSMPUP00000013489	Angiotensin-converting enzyme.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.411
ACE	TMPRSS2	ENSMPUP00000014859	ENSMPUP00000008734	Angiotensin-converting enzyme.	Transmembrane serine protease 2; Belongs to the peptidase S1 family.	0.472
CCL17	CCL2	ENSMPUP00000004366	ENSMPUP00000014730	C-C motif chemokine.	C-C motif chemokine.	0.690
CCL17	CCL22	ENSMPUP00000004366	ENSMPUP00000004347	C-C motif chemokine.	C-C motif chemokine.	0.986
CCL17	CCL5	ENSMPUP00000004366	ENSMPUP00000014852	C-C motif chemokine.	C-C motif chemokine.	0.997
CCL17	CCR2	ENSMPUP00000004366	ENSMPUP00000015187	C-C motif chemokine.	C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family.	0.944
CCL17	CCR5	ENSMPUP00000004366	ENSMPUP00000019524	C-C motif chemokine.	C-C motif chemokine receptor 5 (gene/pseudogene); Belongs to the G-protein coupled receptor 1 family.	0.918
CCL17	CD86	ENSMPUP00000004366	ENSMPUP00000004764	C-C motif chemokine.	CD86 molecule.	0.454
CCL17	CX3CL1	ENSMPUP00000004366	ENSMPUP00000004355	C-C motif chemokine.	C-X3-C motif chemokine ligand 1.	0.490
CCL17	CXCL10	ENSMPUP00000004366	ENSMPUP00000008619	C-C motif chemokine.	C-X-C motif chemokine.	0.716
CCL17	CXCL11	ENSMPUP00000004366	ENSMPUP00000008613	C-C motif chemokine.	C-X-C motif chemokine.	0.654
CCL17	CXCL9	ENSMPUP00000004366	ENSMPUP00000008625	C-C motif chemokine.	C-X-C motif chemokine.	0.708
CCL17	IL10	ENSMPUP00000004366	ENSMPUP00000009891	C-C motif chemokine.	Interleukin 10.	0.643
CCL17	IL15	ENSMPUP00000004366	ENSMPUP00000015989	C-C motif chemokine.	Interleukin; Belongs to the IL-15/IL-21 family.	0.473
CCL17	IL1A	ENSMPUP00000004366	ENSMPUP00000009661	C-C motif chemokine.	Interleukin-1; Belongs to the IL-1 family.	0.447
CCL17	IL1B	ENSMPUP00000004366	ENSMPUP00000010696	C-C motif chemokine.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.535
CCL17	IL4	ENSMPUP00000004366	ENSMPUP00000010424	C-C motif chemokine.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family.	0.622
CCL17	IL6	ENSMPUP00000004366	ENSMPUP00000013489	C-C motif chemokine.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.530
CCL17	TNF	ENSMPUP00000004366	ENSMPUP00000011297	C-C motif chemokine.	Tumor necrosis factor alpha; Belongs to the tumor necrosis factor family.	0.541