STRINGSTRING
SMAD4 SMAD4 BMPR2 BMPR2 SMAD2 SMAD2 SMAD9 SMAD9 CD34 CD34 BMP4 BMP4 BMP10 BMP10 CAV1 CAV1 ACVRL1 ACVRL1 CCNE1 CCNE1 KCNK3 KCNK3 GDF2 GDF2 TGFB3 TGFB3 SMAD5 SMAD5 SOX17 SOX17 TNF TNF ENG ENG TBX4 TBX4 CSK CSK FGF2 FGF2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMAD4Mothers against decapentaplegic homolog. (552 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1045 aa)
SMAD2Mothers against decapentaplegic homolog. (495 aa)
SMAD9Mothers against decapentaplegic homolog. (432 aa)
CD34CD34 molecule. (385 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (410 aa)
KCNK3Potassium channel subfamily K member. (357 aa)
GDF2Growth differentiation factor 2. (429 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
SOX17SRY-box transcription factor 17. (406 aa)
TNFTumor necrosis factor alpha; Belongs to the tumor necrosis factor family. (233 aa)
ENGEndoglin. (653 aa)
TBX4T-box transcription factor 4. (553 aa)
CSKTyrosine-protein kinase. (450 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
Server load: medium (52%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.