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ATP1B1 ATP1B1 IL10RB IL10RB NXPH1 NXPH1 EPHA5 EPHA5 GOLM1 GOLM1 MAPK12 MAPK12 ASB9 ASB9 ACE2 ACE2 BCAT2 BCAT2 IL18 IL18 CSF1 CSF1 INS INS BMP10 BMP10 PDE4A PDE4A MAPT MAPT RETN RETN MZF1 MZF1 GFAP GFAP GFRA3 GFRA3 IL1A IL1A IL1B IL1B RIPK2 RIPK2 TNF TNF PLK1 PLK1 IL18R1 IL18R1 ABL1 ABL1 LCN2 LCN2 IL6 IL6 NAGPA NAGPA ACE ACE FURIN FURIN EPHA4 EPHA4 HGF HGF PRNP PRNP CCR5 CCR5 CCR1 CCR1 JUND JUND
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (300 aa)
IL10RBInterleukin 10 receptor subunit beta. (359 aa)
NXPH1Neurexophilin; May be signaling molecules that resemble neuropeptides. (269 aa)
EPHA5EPH receptor A5. (1037 aa)
GOLM1Golgi membrane protein 1. (406 aa)
MAPK12Mitogen-activated protein kinase. (287 aa)
ASB9Ankyrin repeat and SOCS box containing 9. (293 aa)
ACE2Angiotensin-converting enzyme. (805 aa)
BCAT2Branched chain amino acid transaminase 2. (397 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
CSF1Colony stimulating factor 1. (517 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (109 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
PDE4APhosphodiesterase. (810 aa)
MAPTMicrotubule-associated protein. (770 aa)
RETNResistin. (110 aa)
MZF1Myeloid zinc finger 1. (753 aa)
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (457 aa)
GFRA3GDNF family receptor alpha 3. (409 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (270 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (168 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
TNFTumor necrosis factor alpha; Belongs to the tumor necrosis factor family. (233 aa)
PLK1Serine/threonine-protein kinase PLK. (542 aa)
IL18R1Interleukin 18 receptor 1. (539 aa)
ABL1Tyrosine-protein kinase. (1150 aa)
LCN2Lipocalin 2; Belongs to the calycin superfamily. Lipocalin family. (199 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (210 aa)
NAGPAN-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase. (569 aa)
ACEAngiotensin-converting enzyme. (1247 aa)
FURINFurin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (796 aa)
EPHA4EPH receptor A4. (986 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
PRNPMajor prion protein; Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan s [...] (257 aa)
CCR5C-C motif chemokine receptor 5 (gene/pseudogene); Belongs to the G-protein coupled receptor 1 family. (352 aa)
CCR1C-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (360 aa)
JUNDJunD proto-oncogene, AP-1 transcription factor subunit. (347 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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