19 items (Mustela putorius) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:
	RAMP1	Receptor activity modifying protein 1. (148 aa)
	NGF	Nerve growth factor; Belongs to the NGF-beta family. (241 aa)
	MMP9	Matrix metallopeptidase 9. (704 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (210 aa)
	NPY	Neuropeptide Y. (97 aa)
	HMOX1	Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
	TRPV1	Transient receptor potential cation channel subfamily V member 1. (770 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
	TNF	Tumor necrosis factor alpha; Belongs to the tumor necrosis factor family. (233 aa)
	IL1B	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (168 aa)
	IL4	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (132 aa)
	TRPA1	Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family. (1117 aa)
	IL10	Interleukin 10. (220 aa)
	CD68	CD68 molecule. (325 aa)
	CXCL8	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
	CXCL10	C-X-C motif chemokine. (98 aa)
	MMP8	Matrix metallopeptidase 8. (473 aa)
	TLR4	Toll like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
	TNFRSF11B	Tumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. (401 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD68	CXCL10	ENSMPUP00000009389	ENSMPUP00000008619	CD68 molecule.	C-X-C motif chemokine.	0.562
CD68	HMOX1	ENSMPUP00000009389	ENSMPUP00000012326	CD68 molecule.	Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase.	0.407
CD68	IL10	ENSMPUP00000009389	ENSMPUP00000009891	CD68 molecule.	Interleukin 10.	0.831
CD68	IL1B	ENSMPUP00000009389	ENSMPUP00000010696	CD68 molecule.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.754
CD68	IL4	ENSMPUP00000009389	ENSMPUP00000010424	CD68 molecule.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family.	0.788
CD68	IL6	ENSMPUP00000009389	ENSMPUP00000013489	CD68 molecule.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.905
CD68	MMP9	ENSMPUP00000009389	ENSMPUP00000017496	CD68 molecule.	Matrix metallopeptidase 9.	0.646
CD68	TLR4	ENSMPUP00000009389	ENSMPUP00000001697	CD68 molecule.	Toll like receptor 4; Belongs to the Toll-like receptor family.	0.637
CD68	TNF	ENSMPUP00000009389	ENSMPUP00000011297	CD68 molecule.	Tumor necrosis factor alpha; Belongs to the tumor necrosis factor family.	0.721
CD68	TRPV1	ENSMPUP00000009389	ENSMPUP00000012003	CD68 molecule.	Transient receptor potential cation channel subfamily V member 1.	0.412
CXCL10	CD68	ENSMPUP00000008619	ENSMPUP00000009389	C-X-C motif chemokine.	CD68 molecule.	0.562
CXCL10	CXCL8	ENSMPUP00000008619	ENSMPUP00000009143	C-X-C motif chemokine.	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family.	0.605
CXCL10	IL10	ENSMPUP00000008619	ENSMPUP00000009891	C-X-C motif chemokine.	Interleukin 10.	0.922
CXCL10	IL1B	ENSMPUP00000008619	ENSMPUP00000010696	C-X-C motif chemokine.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.827
CXCL10	IL4	ENSMPUP00000008619	ENSMPUP00000010424	C-X-C motif chemokine.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family.	0.775
CXCL10	IL6	ENSMPUP00000008619	ENSMPUP00000013489	C-X-C motif chemokine.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.857
CXCL10	MMP9	ENSMPUP00000008619	ENSMPUP00000017496	C-X-C motif chemokine.	Matrix metallopeptidase 9.	0.622
CXCL10	TLR4	ENSMPUP00000008619	ENSMPUP00000001697	C-X-C motif chemokine.	Toll like receptor 4; Belongs to the Toll-like receptor family.	0.605
CXCL10	TNF	ENSMPUP00000008619	ENSMPUP00000011297	C-X-C motif chemokine.	Tumor necrosis factor alpha; Belongs to the tumor necrosis factor family.	0.821
CXCL8	CXCL10	ENSMPUP00000009143	ENSMPUP00000008619	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family.	C-X-C motif chemokine.	0.605