(30 nodes) (2023) Cell-intrinsic and -extrinsic effects of SARS-CoV-2 RNA on pathogenesis: single-cell meta-analysis. network (Mustela putorius)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Your Input:
	IL1RN	Interleukin-1. (158 aa)
	IL1B	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (168 aa)
	EPCAM	Epithelial cell adhesion molecule. (324 aa)
	VIM	Vimentin; Belongs to the intermediate filament family. (466 aa)
	FOXJ1	Forkhead box J1. (421 aa)
	ISG15	ISG15 ubiquitin like modifier. (184 aa)
	SCGB1A1	Secretoglobin, family 1A, member 1. (91 aa)
	FCER1G	Fc fragment of IgE receptor Ig. (86 aa)
	TNFRSF12A	TNF receptor superfamily member 12A. (129 aa)
	IFI30	IFI30 lysosomal thiol reductase. (252 aa)
	C1QB	Complement C1q B chain. (249 aa)
	CYP27A1	Cytochrome P450 family 27 subfamily A member 1; Belongs to the cytochrome P450 family. (527 aa)
	COL1A2	Collagen type I alpha 2 chain. (1367 aa)
	IBSP	Integrin binding sialoprotein. (319 aa)
	OAS1	2'-5'-oligoadenylate synthetase 1. (400 aa)
	RARRES1	Retinoic acid receptor responder 1. (292 aa)
	IL18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
	SFTPC	Surfactant protein C. (190 aa)
	CTSS	Cathepsin S; Belongs to the peptidase C1 family. (342 aa)
	CDH5	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (783 aa)
	IRF5	Interferon regulatory factor 5. (504 aa)
	APOC1	Apolipoprotein C1. (88 aa)
	APOE	Apolipoprotein E. (322 aa)
	IFIT2	Interferon induced protein with tetratricopeptide repeats 2. (469 aa)
	CTRL	Chymotrypsin like; Belongs to the peptidase S1 family. (268 aa)
	S100A12	S100 calcium binding protein A12; Belongs to the S-100 family. (92 aa)
	CXCL10	C-X-C motif chemokine. (98 aa)
	IRF7	Interferon regulatory factor 7. (473 aa)
	CD68	CD68 molecule. (325 aa)
	MERTK	MER proto-oncogene, tyrosine kinase. (990 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APOC1	APOE	ENSMPUP00000006148	ENSMPUP00000006175	Apolipoprotein C1.	Apolipoprotein E.	0.919
APOE	APOC1	ENSMPUP00000006175	ENSMPUP00000006148	Apolipoprotein E.	Apolipoprotein C1.	0.919
C1QB	FCER1G	ENSMPUP00000015843	ENSMPUP00000014225	Complement C1q B chain.	Fc fragment of IgE receptor Ig.	0.410
CD68	CXCL10	ENSMPUP00000009389	ENSMPUP00000008619	CD68 molecule.	C-X-C motif chemokine.	0.562
CD68	EPCAM	ENSMPUP00000009389	ENSMPUP00000010950	CD68 molecule.	Epithelial cell adhesion molecule.	0.407
CD68	IL18	ENSMPUP00000009389	ENSMPUP00000003649	CD68 molecule.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.513
CD68	IL1B	ENSMPUP00000009389	ENSMPUP00000010696	CD68 molecule.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.754
CD68	IRF5	ENSMPUP00000009389	ENSMPUP00000005983	CD68 molecule.	Interferon regulatory factor 5.	0.542
CD68	MERTK	ENSMPUP00000009389	ENSMPUP00000009444	CD68 molecule.	MER proto-oncogene, tyrosine kinase.	0.414
CDH5	IL1B	ENSMPUP00000004873	ENSMPUP00000010696	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.443
COL1A2	VIM	ENSMPUP00000001596	ENSMPUP00000011510	Collagen type I alpha 2 chain.	Vimentin; Belongs to the intermediate filament family.	0.595
CTSS	IL1B	ENSMPUP00000004517	ENSMPUP00000010696	Cathepsin S; Belongs to the peptidase C1 family.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.412
CXCL10	CD68	ENSMPUP00000008619	ENSMPUP00000009389	C-X-C motif chemokine.	CD68 molecule.	0.562
CXCL10	IL18	ENSMPUP00000008619	ENSMPUP00000003649	C-X-C motif chemokine.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.753
CXCL10	IL1B	ENSMPUP00000008619	ENSMPUP00000010696	C-X-C motif chemokine.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.827
CXCL10	IL1RN	ENSMPUP00000008619	ENSMPUP00000009465	C-X-C motif chemokine.	Interleukin-1.	0.510
CXCL10	IRF7	ENSMPUP00000008619	ENSMPUP00000008775	C-X-C motif chemokine.	Interferon regulatory factor 7.	0.687
CXCL10	ISG15	ENSMPUP00000008619	ENSMPUP00000013820	C-X-C motif chemokine.	ISG15 ubiquitin like modifier.	0.873
EPCAM	CD68	ENSMPUP00000010950	ENSMPUP00000009389	Epithelial cell adhesion molecule.	CD68 molecule.	0.407
EPCAM	SCGB1A1	ENSMPUP00000010950	ENSMPUP00000013887	Epithelial cell adhesion molecule.	Secretoglobin, family 1A, member 1.	0.455