STRINGSTRING
IL6 IL6 ADAM17 ADAM17 PHKG2 PHKG2 CD44 CD44 RELA RELA TNF TNF CASP3 CASP3 IL1B IL1B STAT3 STAT3 BECN1 BECN1 IL10 IL10 IRF7 IRF7 SMOX SMOX EGF EGF SIRT3 SIRT3 GSK3B GSK3B NOS3 NOS3 MMP7 MMP7 MUC1 MUC1 NOD1 NOD1 PRDX2 PRDX2 CCND1 CCND1 EEF1A1 EEF1A1 IL18 IL18 TRAF3 TRAF3 TLR4 TLR4 C1GALT1 C1GALT1 SOD1 SOD1 JAK1 JAK1 SOCS1 SOCS1 FUT4 FUT4 EGFR EGFR TRIB3 TRIB3 SRC SRC MMP9 MMP9 IL2 IL2 CSK CSK PPARG PPARG ATG7 ATG7 IL33 IL33 BCL2 BCL2 MTOR MTOR WNT1 WNT1 NOS2 NOS2 FTH1 FTH1 CRK CRK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (210 aa)
ADAM17ADAM metallopeptidase domain 17. (822 aa)
PHKG2Phosphorylase kinase catalytic subunit gamma 2; Belongs to the protein kinase superfamily. (406 aa)
CD44CD44 molecule (Indian blood group). (704 aa)
RELARELA proto-oncogene, NF-kB subunit. (511 aa)
TNFTumor necrosis factor alpha; Belongs to the tumor necrosis factor family. (233 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (168 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
BECN1Beclin 1. (448 aa)
IL10Interleukin 10. (220 aa)
IRF7Interferon regulatory factor 7. (473 aa)
SMOXSpermine oxidase. (585 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
SIRT3NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (373 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (420 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1211 aa)
MMP7Matrix metallopeptidase 7. (241 aa)
MUC1SEA domain-containing protein. (560 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (952 aa)
PRDX2Peroxiredoxin 2. (199 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
EEF1A1Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (398 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (569 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
C1GALT1Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1; Glycosyltransferase that generates the core 1 O-glycan Gal- beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins; Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily. (367 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (153 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
SOCS1Suppressor of cytokine signaling 1. (216 aa)
FUT4Fucosyltransferase 4. (511 aa)
EGFRReceptor protein-tyrosine kinase. (1207 aa)
TRIB3Tribbles pseudokinase 3. (358 aa)
SRCTyrosine-protein kinase. (536 aa)
MMP9Matrix metallopeptidase 9. (704 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (152 aa)
CSKTyrosine-protein kinase. (450 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (475 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (788 aa)
IL33Interleukin 33. (268 aa)
BCL2BCL2 apoptosis regulator. (207 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2552 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (340 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1064 aa)
FTH1Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (234 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
Server load: low (8%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.