(9 nodes) (2023) Modeling Paratuberculosis in Laboratory Animals, Cells, or Tissues: A Focus on Their Applications for Pathogenesis, Diagnosis, Vaccines, and Therapy Studies. network (Mustela putorius)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TLR2	Toll like receptor 2; Belongs to the Toll-like receptor family. (785 aa)
	TLR4	Toll like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
	IL10	Interleukin 10. (220 aa)
	IL1B	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (168 aa)
	TNF	Tumor necrosis factor alpha; Belongs to the tumor necrosis factor family. (233 aa)
	CD4	CD4. (462 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (152 aa)
	LGR5	Leucine rich repeat containing G protein-coupled receptor 5. (907 aa)
	TLR1	Toll like receptor 1; Belongs to the Toll-like receptor family. (786 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD4	IL10	ENSMPUP00000016704	ENSMPUP00000009891	CD4.	Interleukin 10.	0.881
CD4	IL1B	ENSMPUP00000016704	ENSMPUP00000010696	CD4.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.832
CD4	IL2	ENSMPUP00000016704	ENSMPUP00000017283	CD4.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.877
CD4	TLR1	ENSMPUP00000016704	ENSMPUP00000020020	CD4.	Toll like receptor 1; Belongs to the Toll-like receptor family.	0.657
CD4	TLR2	ENSMPUP00000016704	ENSMPUP00000018774	CD4.	Toll like receptor 2; Belongs to the Toll-like receptor family.	0.707
CD4	TLR4	ENSMPUP00000016704	ENSMPUP00000001697	CD4.	Toll like receptor 4; Belongs to the Toll-like receptor family.	0.746
CD4	TNF	ENSMPUP00000016704	ENSMPUP00000011297	CD4.	Tumor necrosis factor alpha; Belongs to the tumor necrosis factor family.	0.858
IL10	CD4	ENSMPUP00000009891	ENSMPUP00000016704	Interleukin 10.	CD4.	0.881
IL10	IL1B	ENSMPUP00000009891	ENSMPUP00000010696	Interleukin 10.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.946
IL10	IL2	ENSMPUP00000009891	ENSMPUP00000017283	Interleukin 10.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.904
IL10	TLR1	ENSMPUP00000009891	ENSMPUP00000020020	Interleukin 10.	Toll like receptor 1; Belongs to the Toll-like receptor family.	0.682
IL10	TLR2	ENSMPUP00000009891	ENSMPUP00000018774	Interleukin 10.	Toll like receptor 2; Belongs to the Toll-like receptor family.	0.818
IL10	TLR4	ENSMPUP00000009891	ENSMPUP00000001697	Interleukin 10.	Toll like receptor 4; Belongs to the Toll-like receptor family.	0.811
IL10	TNF	ENSMPUP00000009891	ENSMPUP00000011297	Interleukin 10.	Tumor necrosis factor alpha; Belongs to the tumor necrosis factor family.	0.936
IL1B	CD4	ENSMPUP00000010696	ENSMPUP00000016704	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	CD4.	0.832
IL1B	IL10	ENSMPUP00000010696	ENSMPUP00000009891	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	Interleukin 10.	0.946
IL1B	IL2	ENSMPUP00000010696	ENSMPUP00000017283	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.852
IL1B	TLR1	ENSMPUP00000010696	ENSMPUP00000020020	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	Toll like receptor 1; Belongs to the Toll-like receptor family.	0.709
IL1B	TLR2	ENSMPUP00000010696	ENSMPUP00000018774	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	Toll like receptor 2; Belongs to the Toll-like receptor family.	0.820
IL1B	TLR4	ENSMPUP00000010696	ENSMPUP00000001697	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	Toll like receptor 4; Belongs to the Toll-like receptor family.	0.865