(15 nodes) Phosphoinositide 3-kinase, catalytic domain network (Mustela putorius)

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Your Input:
	PIK3C3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (887 aa)
	PIK3CG	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	TRRAP	Transformation/transcription domain associated protein; Belongs to the PI3/PI4-kinase family. (3276 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2552 aa)
	SMG1	SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family. (3658 aa)
	PIK3C2A	Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family. (1702 aa)
	PIK3C2B	Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family. (1637 aa)
	PIK3C2G	Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma; Belongs to the PI3/PI4-kinase family. (1523 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3057 aa)
	PI4KB	Phosphatidylinositol 4-kinase beta; Belongs to the PI3/PI4-kinase family. (816 aa)
	PI4KA	Phosphatidylinositol 4-kinase alpha; Belongs to the PI3/PI4-kinase family. (2050 aa)
	PRKDC	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4110 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	MTOR	ENSMPUP00000005920	ENSMPUP00000016325	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.544
ATM	PRKDC	ENSMPUP00000005920	ENSMPUP00000001012	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family.	0.782
ATM	SMG1	ENSMPUP00000005920	ENSMPUP00000013293	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family.	0.587
ATM	TRRAP	ENSMPUP00000005920	ENSMPUP00000016453	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Transformation/transcription domain associated protein; Belongs to the PI3/PI4-kinase family.	0.415
MTOR	ATM	ENSMPUP00000016325	ENSMPUP00000005920	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.544
MTOR	PI4KA	ENSMPUP00000016325	ENSMPUP00000003174	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 4-kinase alpha; Belongs to the PI3/PI4-kinase family.	0.433
MTOR	PI4KB	ENSMPUP00000016325	ENSMPUP00000003756	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 4-kinase beta; Belongs to the PI3/PI4-kinase family.	0.414
MTOR	PIK3C3	ENSMPUP00000016325	ENSMPUP00000001010	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.470
MTOR	PIK3CA	ENSMPUP00000016325	ENSMPUP00000017099	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.952
MTOR	PIK3CB	ENSMPUP00000016325	ENSMPUP00000009047	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.952
MTOR	PIK3CD	ENSMPUP00000016325	ENSMPUP00000006192	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.914
MTOR	PIK3CG	ENSMPUP00000016325	ENSMPUP00000018137	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family.	0.596
MTOR	TRRAP	ENSMPUP00000016325	ENSMPUP00000016453	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	Transformation/transcription domain associated protein; Belongs to the PI3/PI4-kinase family.	0.582
PI4KA	MTOR	ENSMPUP00000003174	ENSMPUP00000016325	Phosphatidylinositol 4-kinase alpha; Belongs to the PI3/PI4-kinase family.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.433
PI4KA	PI4KB	ENSMPUP00000003174	ENSMPUP00000003756	Phosphatidylinositol 4-kinase alpha; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 4-kinase beta; Belongs to the PI3/PI4-kinase family.	0.973
PI4KA	PIK3C2A	ENSMPUP00000003174	ENSMPUP00000013244	Phosphatidylinositol 4-kinase alpha; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family.	0.941
PI4KA	PIK3C2B	ENSMPUP00000003174	ENSMPUP00000011605	Phosphatidylinositol 4-kinase alpha; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family.	0.935
PI4KA	PIK3C2G	ENSMPUP00000003174	ENSMPUP00000011358	Phosphatidylinositol 4-kinase alpha; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma; Belongs to the PI3/PI4-kinase family.	0.935
PI4KA	PIK3C3	ENSMPUP00000003174	ENSMPUP00000001010	Phosphatidylinositol 4-kinase alpha; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.945
PI4KA	PRKDC	ENSMPUP00000003174	ENSMPUP00000001012	Phosphatidylinositol 4-kinase alpha; Belongs to the PI3/PI4-kinase family.	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family.	0.425