(30 nodes) Butanoate metabolism network (Mustela putorius)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HADH	Hydroxyacyl-CoA dehydrogenase. (374 aa)
	ACAT1	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (399 aa)
	L2HGDH	L-2-hydroxyglutarate dehydrogenase. (463 aa)
	ACAT2	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (407 aa)
	ALDH5A1	Succinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (434 aa)
	BDH1	3-hydroxybutyrate dehydrogenase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (343 aa)
	ACADS	Acyl-CoA dehydrogenase short chain. (412 aa)
	EHHADH	Enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family. (723 aa)
	HMGCLL1	3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1. (282 aa)
	M3XUN1_MUSPF	Uncharacterized protein. (142 aa)
	M3XTP1_MUSPF	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (176 aa)
	HMGCS2	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (508 aa)
	AACS	Acetoacetyl-CoA synthetase. (729 aa)
	GAD1	Glutamate decarboxylase 1. (594 aa)
	HMGCL	3-hydroxy-3-methylglutaryl-CoA lyase. (322 aa)
	M3YYI0_MUSPF	Uncharacterized protein. (126 aa)
	M3YYI2_MUSPF	Uncharacterized protein. (111 aa)
	ABAT	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (518 aa)
	OXCT1	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. (520 aa)
	HMGCS1	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (520 aa)
	CARTPT	CART prepropeptide. (116 aa)
	ACSM3	Acyl-CoA synthetase medium chain family member 3. (586 aa)
	ACSM5	Acyl-CoA synthetase medium chain family member 5. (579 aa)
	M3YP35_MUSPF	Uncharacterized protein. (578 aa)
	ACSM1	Acyl-CoA synthetase medium chain family member 1. (577 aa)
	M3YP11_MUSPF	Uncharacterized protein. (514 aa)
	GAD2	Glutamate decarboxylase 2. (585 aa)
	M3YGI2_MUSPF	AMP-binding domain-containing protein. (93 aa)
	BDH2	3-hydroxybutyrate dehydrogenase 2. (245 aa)
	HADHA	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha; Belongs to the enoyl-CoA hydratase/isomerase family. (763 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AACS	ACAT1	ENSMPUP00000001382	ENSMPUP00000005986	Acetoacetyl-CoA synthetase.	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	0.923
AACS	ACAT2	ENSMPUP00000001382	ENSMPUP00000004991	Acetoacetyl-CoA synthetase.	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	0.903
AACS	ALDH5A1	ENSMPUP00000001382	ENSMPUP00000004621	Acetoacetyl-CoA synthetase.	Succinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.549
AACS	BDH1	ENSMPUP00000001382	ENSMPUP00000003736	Acetoacetyl-CoA synthetase.	3-hydroxybutyrate dehydrogenase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.911
AACS	BDH2	ENSMPUP00000001382	ENSMPUP00000009169	Acetoacetyl-CoA synthetase.	3-hydroxybutyrate dehydrogenase 2.	0.881
AACS	CARTPT	ENSMPUP00000001382	ENSMPUP00000014303	Acetoacetyl-CoA synthetase.	CART prepropeptide.	0.571
AACS	EHHADH	ENSMPUP00000001382	ENSMPUP00000002996	Acetoacetyl-CoA synthetase.	Enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family.	0.884
AACS	HADH	ENSMPUP00000001382	ENSMPUP00000008821	Acetoacetyl-CoA synthetase.	Hydroxyacyl-CoA dehydrogenase.	0.899
AACS	HADHA	ENSMPUP00000001382	ENSMPUP00000008481	Acetoacetyl-CoA synthetase.	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha; Belongs to the enoyl-CoA hydratase/isomerase family.	0.782
AACS	HMGCL	ENSMPUP00000001382	ENSMPUP00000015740	Acetoacetyl-CoA synthetase.	3-hydroxy-3-methylglutaryl-CoA lyase.	0.900
AACS	HMGCLL1	ENSMPUP00000001382	ENSMPUP00000002783	Acetoacetyl-CoA synthetase.	3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1.	0.899
AACS	HMGCS1	ENSMPUP00000001382	ENSMPUP00000014322	Acetoacetyl-CoA synthetase.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.912
AACS	HMGCS2	ENSMPUP00000001382	ENSMPUP00000001436	Acetoacetyl-CoA synthetase.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.924
AACS	M3XTP1_MUSPF	ENSMPUP00000001382	ENSMPUP00000002441	Acetoacetyl-CoA synthetase.	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family.	0.464
AACS	M3XUN1_MUSPF	ENSMPUP00000001382	ENSMPUP00000002781	Acetoacetyl-CoA synthetase.	Uncharacterized protein.	0.496
AACS	M3YP35_MUSPF	ENSMPUP00000001382	ENSMPUP00000013092	Acetoacetyl-CoA synthetase.	Uncharacterized protein.	0.469
AACS	OXCT1	ENSMPUP00000001382	ENSMPUP00000014361	Acetoacetyl-CoA synthetase.	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.	0.883
ABAT	ACADS	ENSMPUP00000014632	ENSMPUP00000003238	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Acyl-CoA dehydrogenase short chain.	0.858
ABAT	ALDH5A1	ENSMPUP00000014632	ENSMPUP00000004621	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Succinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.985
ABAT	EHHADH	ENSMPUP00000014632	ENSMPUP00000002996	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family.	0.936