(34 nodes) Terpenoid backbone biosynthesis network (Mustela putorius)

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second shell of interactors

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proteins of unknown 3D structure

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Your Input:
	TOMM70	Translocase of outer mitochondrial membrane 70. (609 aa)
	M3Y636_MUSPF	Protein farnesyltransferase subunit beta; Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. (487 aa)
	CHURC1	Churchill domain containing 1. (112 aa)
	PMVK	Phosphomevalonate kinase. (201 aa)
	SLC35F2	Solute carrier family 35 member F2. (327 aa)
	DHDDS	Alkyl transferase; Belongs to the UPP synthase family. (334 aa)
	HMGCS1	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (520 aa)
	CARTPT	CART prepropeptide. (116 aa)
	GGPS1	Geranylgeranyl diphosphate synthase 1; Belongs to the FPP/GGPP synthase family. (300 aa)
	SLC35F1	Solute carrier family 35 member F1. (349 aa)
	NUS1	NUS1 dehydrodolichyl diphosphate synthase subunit. (293 aa)
	PCYOX1L	Prenylcysteine oxidase 1 like. (494 aa)
	M3Y2A4_MUSPF	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (421 aa)
	M3Y292_MUSPF	Uncharacterized protein. (439 aa)
	ZC3HC1	Zinc finger C3HC-type containing 1. (505 aa)
	PCYOX1	Prenylcysteine oxidase 1. (505 aa)
	ZMPSTE24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
	RCE1	Ras converting CAAX endopeptidase 1. (329 aa)
	PDSS1	Decaprenyl diphosphate synthase subunit 1; Belongs to the FPP/GGPP synthase family. (419 aa)
	HMGCS2	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (508 aa)
	LOC101681900	SH3 domain-containing protein. (413 aa)
	FNTA	Farnesyltransferase, CAAX box, alpha. (418 aa)
	ICMT	Protein-S-isoprenylcysteine O-methyltransferase. (242 aa)
	ACAT1	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (399 aa)
	M3XV12_MUSPF	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (345 aa)
	RIOK3	Serine/threonine-protein kinase RIO3; Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. (519 aa)
	HMGCR	3-hydroxy-3-methylglutaryl coenzyme A reductase. (914 aa)
	MVK	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (399 aa)
	ACAT2	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (407 aa)
	RUSC2	RUN and SH3 domain containing 2. (1511 aa)
	MVD	Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. (400 aa)
	CTDP1	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (759 aa)
	PDSS2	Decaprenyl diphosphate synthase subunit 2; Belongs to the FPP/GGPP synthase family. (400 aa)
	KIF18A	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (897 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACAT1	ACAT2	ENSMPUP00000005986	ENSMPUP00000004991	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	0.942
ACAT1	HMGCS1	ENSMPUP00000005986	ENSMPUP00000014322	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.990
ACAT1	HMGCS2	ENSMPUP00000005986	ENSMPUP00000001436	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.991
ACAT1	MVD	ENSMPUP00000005986	ENSMPUP00000008056	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes.	0.501
ACAT1	MVK	ENSMPUP00000005986	ENSMPUP00000003866	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	0.659
ACAT2	ACAT1	ENSMPUP00000004991	ENSMPUP00000005986	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	0.942
ACAT2	HMGCR	ENSMPUP00000004991	ENSMPUP00000005617	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.522
ACAT2	HMGCS1	ENSMPUP00000004991	ENSMPUP00000014322	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.991
ACAT2	HMGCS2	ENSMPUP00000004991	ENSMPUP00000001436	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.987
ACAT2	MVD	ENSMPUP00000004991	ENSMPUP00000008056	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes.	0.535
ACAT2	MVK	ENSMPUP00000004991	ENSMPUP00000003866	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	0.661
CARTPT	HMGCS1	ENSMPUP00000014303	ENSMPUP00000014322	CART prepropeptide.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.899
CARTPT	HMGCS2	ENSMPUP00000014303	ENSMPUP00000001436	CART prepropeptide.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.899
CARTPT	MVD	ENSMPUP00000014303	ENSMPUP00000008056	CART prepropeptide.	Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes.	0.501
CARTPT	MVK	ENSMPUP00000014303	ENSMPUP00000003866	CART prepropeptide.	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	0.659
CHURC1	DHDDS	ENSMPUP00000006738	ENSMPUP00000015598	Churchill domain containing 1.	Alkyl transferase; Belongs to the UPP synthase family.	0.605
CHURC1	FNTA	ENSMPUP00000006738	ENSMPUP00000012714	Churchill domain containing 1.	Farnesyltransferase, CAAX box, alpha.	0.948
CHURC1	GGPS1	ENSMPUP00000006738	ENSMPUP00000002891	Churchill domain containing 1.	Geranylgeranyl diphosphate synthase 1; Belongs to the FPP/GGPP synthase family.	0.575
CHURC1	M3XV12_MUSPF	ENSMPUP00000006738	ENSMPUP00000002912	Churchill domain containing 1.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.475
CHURC1	M3Y292_MUSPF	ENSMPUP00000006738	ENSMPUP00000005443	Churchill domain containing 1.	Uncharacterized protein.	0.447