STRINGSTRING
EIF4EBP1 EIF4EBP1 MAP2K1 MAP2K1 JAK1 JAK1 GAB1 GAB1 ERBB3 ERBB3 M3XSH0_MUSPF M3XSH0_MUSPF AKT1 AKT1 FGFR2 FGFR2 MAPK1 MAPK1 BAX BAX BRAF BRAF RPS6KB2 RPS6KB2 M3Y027_MUSPF M3Y027_MUSPF JAK2 JAK2 SOS2 SOS2 KDR KDR M3Y1G8_MUSPF M3Y1G8_MUSPF M3Y2Z6_MUSPF M3Y2Z6_MUSPF PDGFC PDGFC CSDE1 CSDE1 PDGFRA PDGFRA SHC1 SHC1 PIK3CD PIK3CD PDGFD PDGFD MET MET TGFA TGFA IL6R IL6R GSK3B GSK3B SHC3 SHC3 EGF EGF NRG2 NRG2 PIK3CB PIK3CB GAS6 GAS6 PLCG2 PLCG2 BCL2L11 BCL2L11 FOXO3 FOXO3 SHC2 SHC2 PRKCG PRKCG NRG1 NRG1 KRAS KRAS SOS1 SOS1 STAT3 STAT3 M3YH29_MUSPF M3YH29_MUSPF IGF1R IGF1R FGFR3 FGFR3 IGF1 IGF1 PRKCB PRKCB SHC4 SHC4 EIF4E1B EIF4E1B MAPK3 MAPK3 VEGFA VEGFA BAD BAD M3YNJ8_MUSPF M3YNJ8_MUSPF PPP1R14B PPP1R14B PDGFB PDGFB ARAF ARAF IL6 IL6 GRB2 GRB2 PDGFRB PDGFRB NF1 NF1 PRKCA PRKCA PIK3R1 PIK3R1 ERBB2 ERBB2 RPS6KB1 RPS6KB1 M3YWA8_MUSPF M3YWA8_MUSPF AKT3 AKT3 M3YX47_MUSPF M3YX47_MUSPF MTOR MTOR BCL2 BCL2 M3YZX8_MUSPF M3YZX8_MUSPF RAF1 RAF1 PIK3CA PIK3CA FGF2 FGF2 AXL AXL PLCG1 PLCG1 AKT2 AKT2 SRC SRC PDGFA PDGFA BCL2L1 BCL2L1 EGFR EGFR HGF HGF M3Z5X1_MUSPF M3Z5X1_MUSPF M3Z826_MUSPF M3Z826_MUSPF M3Z8B6_MUSPF M3Z8B6_MUSPF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (118 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
GAB1GRB2 associated binding protein 1. (648 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1339 aa)
M3XSH0_MUSPFUncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (219 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
FGFR2Fibroblast growth factor receptor. (842 aa)
MAPK1Mitogen-activated protein kinase. (333 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (715 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (479 aa)
M3Y027_MUSPFProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
JAK2Tyrosine-protein kinase. (1130 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1281 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1355 aa)
M3Y1G8_MUSPFUncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (245 aa)
M3Y2Z6_MUSPFUncharacterized protein. (189 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
CSDE1Cold shock domain containing E1. (784 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1087 aa)
SHC1SHC adaptor protein 1. (586 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
PDGFDPlatelet derived growth factor D. (364 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1540 aa)
TGFATransforming growth factor alpha. (158 aa)
IL6RInterleukin 6 receptor. (436 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (420 aa)
SHC3SHC adaptor protein 3. (425 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
NRG2Neuregulin 2. (648 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
GAS6Growth arrest specific 6. (541 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1266 aa)
BCL2L11BCL2 like 11. (232 aa)
FOXO3Forkhead box O3. (671 aa)
SHC2Uncharacterized protein. (539 aa)
PRKCGNon-specific serine/threonine protein kinase. (569 aa)
NRG1Neuregulin 1. (609 aa)
KRASKRAS proto-oncogene, GTPase. (208 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1276 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
M3YH29_MUSPFUncharacterized protein. (180 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
FGFR3Fibroblast growth factor receptor. (802 aa)
IGF1Insulin like growth factor 1. (153 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (577 aa)
SHC4SHC adaptor protein 4. (624 aa)
EIF4E1BEukaryotic translation initiation factor 4E family member 1B; Belongs to the eukaryotic initiation factor 4E family. (263 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (399 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (398 aa)
BADBCL2 associated agonist of cell death. (168 aa)
M3YNJ8_MUSPFUncharacterized protein. (461 aa)
PPP1R14BProtein phosphatase 1 regulatory inhibitor subunit 14B. (145 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (242 aa)
ARAFV-raf murine sarcoma 3611 viral oncoprotein-like protein. (606 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (210 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1137 aa)
NF1Neurofibromin 1. (2815 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (688 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
ERBB2Receptor protein-tyrosine kinase. (1260 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
M3YWA8_MUSPFUncharacterized protein. (726 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa)
M3YX47_MUSPFUncharacterized protein. (94 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2552 aa)
BCL2BCL2 apoptosis regulator. (207 aa)
M3YZX8_MUSPFUncharacterized protein. (144 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (644 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
AXLAXL receptor tyrosine kinase. (887 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
SRCTyrosine-protein kinase. (536 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
BCL2L1BCL2 like 1. (233 aa)
EGFRReceptor protein-tyrosine kinase. (1207 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
M3Z5X1_MUSPFUncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (217 aa)
M3Z826_MUSPF40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (243 aa)
M3Z8B6_MUSPFUncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (216 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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