STRINGSTRING
JAG1 JAG1 MAP2K1 MAP2K1 MAPK9 MAPK9 ABCB11 ABCB11 ADCY8 ADCY8 NOTCH2 NOTCH2 RB1 RB1 PTK2 PTK2 CDK4 CDK4 M3XSG7_MUSPF M3XSG7_MUSPF M3XSG8_MUSPF M3XSG8_MUSPF AKT1 AKT1 MAPK11 MAPK11 MAPK10 MAPK10 MAPK12 MAPK12 PRKACA PRKACA M3XVK5_MUSPF M3XVK5_MUSPF M3XVL1_MUSPF M3XVL1_MUSPF MAPK1 MAPK1 M3XVL3_MUSPF M3XVL3_MUSPF M3XVL5_MUSPF M3XVL5_MUSPF ADCY7 ADCY7 BAX BAX MMP2 MMP2 BRAF BRAF RPS6KB2 RPS6KB2 MAPK14 MAPK14 MAPK13 MAPK13 ADCY5 ADCY5 CCND1 CCND1 M3Y027_MUSPF M3Y027_MUSPF E2F3 E2F3 SOS2 SOS2 M3Y183_MUSPF M3Y183_MUSPF ADCY4 ADCY4 M3Y2Z6_MUSPF M3Y2Z6_MUSPF CARM1 CARM1 CSDE1 CSDE1 PRKACB PRKACB SP1 SP1 SHC1 SHC1 PIK3CD PIK3CD ESR2 ESR2 LOC101676235 LOC101676235 M3Y692_MUSPF M3Y692_MUSPF DLL1 DLL1 CDKN2C CDKN2C MMP20 MMP20 ADCY2 ADCY2 SHC3 SHC3 DLL4 DLL4 HBEGF HBEGF TP53 TP53 PIK3CB PIK3CB MAPK8 MAPK8 FOS FOS SHC2 SHC2 NOTCH4 NOTCH4 NCOR1 NCOR1 KRAS KRAS CCDC170 CCDC170 SOS1 SOS1 ESR1 ESR1 M3YH29_MUSPF M3YH29_MUSPF IGF1R IGF1R NOTCH1 NOTCH1 IGF1 IGF1 SHC4 SHC4 MAPK3 MAPK3 BAD BAD M3YNJ8_MUSPF M3YNJ8_MUSPF PPP1R14B PPP1R14B ARAF ARAF GRB2 GRB2 PTRHD1 PTRHD1 ADCY3 ADCY3 CDKN1A CDKN1A PIK3R1 PIK3R1 ADCY6 ADCY6 ERBB2 ERBB2 M3YU90_MUSPF M3YU90_MUSPF ADCY9 ADCY9 RPS6KB1 RPS6KB1 M3YWA8_MUSPF M3YWA8_MUSPF AKT3 AKT3 E2F2 E2F2 CDKN2A CDKN2A NOTCH3 NOTCH3 MTOR MTOR BCL2 BCL2 RAF1 RAF1 PIK3CA PIK3CA MDM2 MDM2 NCOA3 NCOA3 MMP9 MMP9 AKT2 AKT2 DLL3 DLL3 SRC SRC E2F1 E2F1 EGFR EGFR ADCY1 ADCY1 GPER1 GPER1 JUN JUN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
MAPK9Mitogen-activated protein kinase. (398 aa)
ABCB11ATP binding cassette subfamily B member 11. (1325 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa)
NOTCH2Notch receptor 2. (2471 aa)
RB1RB transcriptional corepressor 1. (948 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1096 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (305 aa)
M3XSG7_MUSPFUncharacterized protein. (233 aa)
M3XSG8_MUSPFUncharacterized protein. (429 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
MAPK11Mitogen-activated protein kinase. (434 aa)
MAPK10Mitogen-activated protein kinase. (384 aa)
MAPK12Mitogen-activated protein kinase. (287 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
M3XVK5_MUSPFUncharacterized protein. (1274 aa)
M3XVL1_MUSPFUncharacterized protein. (68 aa)
MAPK1Mitogen-activated protein kinase. (333 aa)
M3XVL3_MUSPFUncharacterized protein. (168 aa)
M3XVL5_MUSPFUncharacterized protein. (105 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
MMP2Matrix metallopeptidase 2. (661 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (715 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (479 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1018 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
M3Y027_MUSPFProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
E2F3E2F transcription factor 3. (340 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1281 aa)
M3Y183_MUSPFUncharacterized protein. (131 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1105 aa)
M3Y2Z6_MUSPFUncharacterized protein. (189 aa)
CARM1Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (557 aa)
CSDE1Cold shock domain containing E1. (784 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
SP1Sp1 transcription factor. (787 aa)
SHC1SHC adaptor protein 1. (586 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
ESR2Estrogen receptor 2. (521 aa)
LOC101676235Uncharacterized protein. (531 aa)
M3Y692_MUSPFUncharacterized protein. (362 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (602 aa)
CDKN2CCyclin dependent kinase inhibitor 2C. (168 aa)
MMP20Matrix metallopeptidase 20. (417 aa)
ADCY2Adenylate cyclase 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (880 aa)
SHC3SHC adaptor protein 3. (425 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (375 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
MAPK8Mitogen-activated protein kinase. (397 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (446 aa)
SHC2Uncharacterized protein. (539 aa)
NOTCH4Notch receptor 4. (1993 aa)
NCOR1Nuclear receptor corepressor 1. (2510 aa)
KRASKRAS proto-oncogene, GTPase. (208 aa)
CCDC170Coiled-coil domain containing 170. (701 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1276 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (597 aa)
M3YH29_MUSPFUncharacterized protein. (180 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
NOTCH1Notch receptor 1. (2119 aa)
IGF1Insulin like growth factor 1. (153 aa)
SHC4SHC adaptor protein 4. (624 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (399 aa)
BADBCL2 associated agonist of cell death. (168 aa)
M3YNJ8_MUSPFUncharacterized protein. (461 aa)
PPP1R14BProtein phosphatase 1 regulatory inhibitor subunit 14B. (145 aa)
ARAFV-raf murine sarcoma 3611 viral oncoprotein-like protein. (606 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
ERBB2Receptor protein-tyrosine kinase. (1260 aa)
M3YU90_MUSPFMediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (616 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
M3YWA8_MUSPFUncharacterized protein. (726 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa)
E2F2E2F transcription factor 2. (440 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (152 aa)
NOTCH3Notch receptor 3. (2305 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2552 aa)
BCL2BCL2 apoptosis regulator. (207 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (644 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (487 aa)
NCOA3Nuclear receptor coactivator. (1416 aa)
MMP9Matrix metallopeptidase 9. (704 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
DLL3Delta like canonical Notch ligand 3. (590 aa)
SRCTyrosine-protein kinase. (536 aa)
E2F1E2F transcription factor 1. (354 aa)
EGFRReceptor protein-tyrosine kinase. (1207 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1130 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (359 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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