STRINGSTRING
TP53 TP53 M3YBZ6_MUSPF M3YBZ6_MUSPF M3YBZ1_MUSPF M3YBZ1_MUSPF ERCC1 ERCC1 M3YBY4_MUSPF M3YBY4_MUSPF M3YBC5_MUSPF M3YBC5_MUSPF MSH3 MSH3 M3Y9E6_MUSPF M3Y9E6_MUSPF SLC31A1 SLC31A1 BIRC3 BIRC3 BIRC2 BIRC2 FAS FAS XPA XPA M3Y4G5_MUSPF M3Y4G5_MUSPF PIK3CD PIK3CD ATM ATM M3Z4Y0_MUSPF M3Z4Y0_MUSPF ATP7B ATP7B BCL2L1 BCL2L1 AKT2 AKT2 MDM2 MDM2 PIK3CA PIK3CA ABCC2 ABCC2 GSTO1 GSTO1 GSTO2 GSTO2 BCL2 BCL2 CASP9 CASP9 MGST2 MGST2 CDKN2A CDKN2A AKT3 AKT3 ATP7A ATP7A CASP8 CASP8 XIAP XIAP AKT1 AKT1 BAK1 BAK1 MLH1 MLH1 M3XV21_MUSPF M3XV21_MUSPF M3XV27_MUSPF M3XV27_MUSPF M3XV34_MUSPF M3XV34_MUSPF M3XV40_MUSPF M3XV40_MUSPF MAPK1 MAPK1 M3XVS8_MUSPF M3XVS8_MUSPF BAX BAX M3XX29_MUSPF M3XX29_MUSPF GSTM3 GSTM3 MGST3 MGST3 M3XY39_MUSPF M3XY39_MUSPF M3XY45_MUSPF M3XY45_MUSPF C7orf31 C7orf31 FADD FADD M3Y0R3_MUSPF M3Y0R3_MUSPF M3YWA8_MUSPF M3YWA8_MUSPF FASLG FASLG PDPK1 PDPK1 ERBB2 ERBB2 MAP3K5 MAP3K5 PIK3R1 PIK3R1 TOP2A TOP2A CDKN1A CDKN1A BIRC5 BIRC5 PPP1R14B PPP1R14B M3YNJ8_MUSPF M3YNJ8_MUSPF BAD BAD POLH POLH MAPK3 MAPK3 TOP2B TOP2B MGST1 MGST1 APAF1 APAF1 CASP3 CASP3 MSH2 MSH2 MSH6 MSH6 REV3L REV3L M3YEG5_MUSPF M3YEG5_MUSPF M3YDX4_MUSPF M3YDX4_MUSPF PIK3CB PIK3CB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (375 aa)
M3YBZ6_MUSPFGlutathione S-transferase. (225 aa)
M3YBZ1_MUSPFUncharacterized protein. (222 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (294 aa)
M3YBY4_MUSPFUncharacterized protein; Belongs to the GST superfamily. (203 aa)
M3YBC5_MUSPFUncharacterized protein. (130 aa)
MSH3MutS homolog 3. (869 aa)
M3Y9E6_MUSPFUncharacterized protein. (203 aa)
SLC31A1Solute carrier family 31 member 1. (206 aa)
BIRC3Baculoviral IAP repeat containing 3. (604 aa)
BIRC2Baculoviral IAP repeat containing 2. (570 aa)
FASFas cell surface death receptor. (311 aa)
XPAXPA, DNA damage recognition and repair factor. (275 aa)
M3Y4G5_MUSPFUncharacterized protein. (221 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3057 aa)
M3Z4Y0_MUSPFCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
ATP7BATPase copper transporting beta. (1495 aa)
BCL2L1BCL2 like 1. (233 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (487 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ABCC2ATP binding cassette subfamily C member 2. (1544 aa)
GSTO1Glutathione S-transferase omega 1. (240 aa)
GSTO2Glutathione S-transferase omega 2; Belongs to the GST superfamily. (243 aa)
BCL2BCL2 apoptosis regulator. (207 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (451 aa)
MGST2Microsomal glutathione S-transferase 2. (146 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (152 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa)
ATP7AATPase copper transporting alpha. (1508 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (484 aa)
XIAPX-linked inhibitor of apoptosis. (497 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
MLH1MutL homolog 1. (758 aa)
M3XV21_MUSPFUncharacterized protein. (240 aa)
M3XV27_MUSPFUncharacterized protein; Belongs to the GST superfamily. (240 aa)
M3XV34_MUSPFUncharacterized protein; Belongs to the GST superfamily. (242 aa)
M3XV40_MUSPFUncharacterized protein; Belongs to the GST superfamily. (250 aa)
MAPK1Mitogen-activated protein kinase. (333 aa)
M3XVS8_MUSPFCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
M3XX29_MUSPFUncharacterized protein; Belongs to the GST superfamily. (218 aa)
GSTM3Glutathione S-transferase. (226 aa)
MGST3Microsomal glutathione S-transferase 3. (166 aa)
M3XY39_MUSPFUncharacterized protein; Belongs to the GST superfamily. (210 aa)
M3XY45_MUSPFUncharacterized protein; Belongs to the GST superfamily. (193 aa)
C7orf31Chromosome 7 open reading frame 31. (589 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (216 aa)
M3Y0R3_MUSPFUncharacterized protein. (201 aa)
M3YWA8_MUSPFUncharacterized protein. (726 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (275 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (531 aa)
ERBB2Receptor protein-tyrosine kinase. (1260 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1398 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
TOP2ADNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1511 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
BIRC5Baculoviral IAP repeat containing 5. (142 aa)
PPP1R14BProtein phosphatase 1 regulatory inhibitor subunit 14B. (145 aa)
M3YNJ8_MUSPFUncharacterized protein. (461 aa)
BADBCL2 associated agonist of cell death. (168 aa)
POLHDNA polymerase eta. (649 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (399 aa)
TOP2BDNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1542 aa)
MGST1Microsomal glutathione S-transferase 1. (155 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1250 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1360 aa)
REV3LREV3 like, DNA directed polymerase zeta catalytic subunit. (3130 aa)
M3YEG5_MUSPFBreast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (766 aa)
M3YDX4_MUSPFUncharacterized protein; Belongs to the GST superfamily. (184 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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