(99 nodes) PPAR signaling pathway network (Mustela putorius)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	M3Z655_MUSPF	FABP domain-containing protein. (134 aa)
	CYP8B1	Cytochrome P450 family 8 subfamily B member 1; Belongs to the cytochrome P450 family. (499 aa)
	M3Z713_MUSPF	ACB domain-containing protein. (87 aa)
	GK2	Glycerol kinase 2; Belongs to the FGGY kinase family. (552 aa)
	PKIB	cAMP-dependent protein kinase inhibitor; Belongs to the PKI family. (78 aa)
	FABP7	Fatty acid binding protein 7; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (137 aa)
	M3YTG0_MUSPF	Uncharacterized protein. (73 aa)
	PDPK1	3-phosphoinositide dependent protein kinase 1. (531 aa)
	FABP3	Fatty acid binding protein 3; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (135 aa)
	PLIN1	Perilipin; Belongs to the perilipin family. (480 aa)
	SLC27A1	Solute carrier family 27 member 1. (646 aa)
	UCP1	Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (307 aa)
	PPARA	Peroxisome proliferator activated receptor alpha. (468 aa)
	CYP27A1	Cytochrome P450 family 27 subfamily A member 1; Belongs to the cytochrome P450 family. (527 aa)
	ACSL3	Acyl-CoA synthetase long chain family member 3. (720 aa)
	ACOX2	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (680 aa)
	SCD	Stearoyl-CoA desaturase; Belongs to the fatty acid desaturase type 1 family. (359 aa)
	SORBS1	Sorbin and SH3 domain containing 1. (1169 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (475 aa)
	FABP2	Fatty acid binding protein 2; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
	PLTP	Phospholipid transfer protein. (483 aa)
	CD36	CD36 molecule; Belongs to the CD36 family. (472 aa)
	M3XM85_MUSPF	Cytochrome b5 heme-binding domain-containing protein. (480 aa)
	M3XPD9_MUSPF	ACB domain-containing protein. (87 aa)
	HMGCS2	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (508 aa)
	FABP12	Fatty acid binding protein 12; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (149 aa)
	FABP4	Fatty acid binding protein 4; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
	FABP9	Fatty acid binding protein 9; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
	PMP2	Peripheral myelin protein 2; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
	CPT1B	Carnitine palmitoyltransferase 1B; Belongs to the carnitine/choline acetyltransferase family. (772 aa)
	ACSL5	Acyl-CoA synthetase long chain family member 5. (724 aa)
	RXRB	Retinoid X receptor beta. (532 aa)
	CPT1C	Carnitine palmitoyltransferase 1C; Belongs to the carnitine/choline acetyltransferase family. (803 aa)
	LPL	Lipoprotein lipase. (478 aa)
	M3XTZ0_MUSPF	Uncharacterized protein; Belongs to the FGGY kinase family. (559 aa)
	ACAA1	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (425 aa)
	EHHADH	Enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family. (723 aa)
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (244 aa)
	PPARD	Peroxisome proliferator activated receptor delta. (366 aa)
	SORBS3	Sorbin and SH3 domain containing 3. (732 aa)
	RXRG	Retinoid X receptor gamma. (463 aa)
	ACSL4	Acyl-CoA synthetase long chain family member 4. (670 aa)
	M3XYB6_MUSPF	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (334 aa)
	APOA5	Apolipoprotein A5. (370 aa)
	APOC3	Apolipoprotein C3. (100 aa)
	APOA1	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. (323 aa)
	SIK3	SIK family kinase 3. (1188 aa)
	CPT1A	Carnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. (773 aa)
	ANKRD24	Ankyrin repeat domain 24. (920 aa)
	NR1H3	Nuclear receptor subfamily 1 group H member 3. (447 aa)
	M3Y157_MUSPF	Uncharacterized protein. (548 aa)
	PLIN5	Perilipin; Belongs to the perilipin family. (480 aa)
	PLIN3	Perilipin; Belongs to the perilipin family. (437 aa)
	ME1	Malic enzyme. (572 aa)
	ILK	Integrin linked kinase. (452 aa)
	PCK2	Phosphoenolpyruvate carboxykinase 2, mitochondrial. (620 aa)
	ACSBG2	Acyl-CoA synthetase bubblegum family member 2. (672 aa)
	OLR1	Oxidized low density lipoprotein receptor 1. (278 aa)
	LOC101686534	AMP-binding domain-containing protein. (684 aa)
	CPT2	Carnitine palmitoyltransferase 2; Belongs to the carnitine/choline acetyltransferase family. (675 aa)
	PCK1	Phosphoenolpyruvate carboxykinase 1. (622 aa)
	SCP2	Sterol carrier protein 2; Belongs to the thiolase-like superfamily. Thiolase family. (547 aa)
	MMP1	Matrix metallopeptidase 1. (470 aa)
	MMP8	Matrix metallopeptidase 8. (473 aa)
	ANGPTL4	Angiopoietin like 4. (412 aa)
	SLC27A2	Solute carrier family 27 member 2. (607 aa)
	ACADL	Acyl-CoA dehydrogenase long chain. (430 aa)
	SLC27A5	Solute carrier family 27 member 5. (687 aa)
	NR1I2	Nuclear receptor subfamily 1 group I member 2. (324 aa)
	FABP1	Fatty acid binding protein 1. (127 aa)
	UCP3	Uncoupling protein 3; Belongs to the mitochondrial carrier (TC 2.A.29) family. (311 aa)
	UCP2	Uncoupling protein 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (309 aa)
	ARMC2	Armadillo repeat containing 2. (866 aa)
	ME3	Malic enzyme. (543 aa)
	CYP7A1	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (501 aa)
	ACOX3	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (699 aa)
	PLIN2	Perilipin; Belongs to the perilipin family. (437 aa)
	ACADM	Acyl-CoA dehydrogenase medium chain. (421 aa)
	ACSBG1	Acyl-CoA synthetase bubblegum family member 1. (731 aa)
	ACSL1	Acyl-CoA synthetase long chain family member 1. (724 aa)
	SORBS2	Sorbin and SH3 domain containing 2. (1352 aa)
	M3YJH0_MUSPF	AMP-binding domain-containing protein. (697 aa)
	M3YK31_MUSPF	Uncharacterized protein. (263 aa)
	M3YKF7_MUSPF	Uncharacterized protein; Belongs to the FGGY kinase family. (524 aa)
	RXRA	Retinoid X receptor alpha. (548 aa)
	M3YLZ2_MUSPF	Uncharacterized protein; Belongs to the cytochrome P450 family. (510 aa)
	M3YM59_MUSPF	Uncharacterized protein. (454 aa)
	M3YM64_MUSPF	Uncharacterized protein; Belongs to the cytochrome P450 family. (513 aa)
	M3YMP3_MUSPF	Uncharacterized protein; Belongs to the cytochrome P450 family. (510 aa)
	CYP4B1	Cytochrome P450 family 4 subfamily B member 1; Belongs to the cytochrome P450 family. (546 aa)
	SLC27A4	Solute carrier family 27 member 4. (651 aa)
	FABP6	Fatty acid binding protein 6. (150 aa)
	ACOX1	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (661 aa)
	FADS3	Fatty acid desaturase 3. (443 aa)
	FADS2	Fatty acid desaturase 2. (444 aa)
	UFC1	Ubiquitin-fold modifier-conjugating enzyme 1; E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage. (167 aa)
	APOA2	Apolipoprotein A2. (100 aa)
	HMGCS1	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (520 aa)
	M3Z5Z4_MUSPF	FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (135 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACAA1	ACADL	ENSMPUP00000002732	ENSMPUP00000007879	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Acyl-CoA dehydrogenase long chain.	0.963
ACAA1	ACADM	ENSMPUP00000002732	ENSMPUP00000010810	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Acyl-CoA dehydrogenase medium chain.	0.971
ACAA1	ACOX1	ENSMPUP00000002732	ENSMPUP00000013576	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.983
ACAA1	ACOX2	ENSMPUP00000002732	ENSMPUP00000016796	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.854
ACAA1	ACOX3	ENSMPUP00000002732	ENSMPUP00000010449	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.961
ACAA1	ACSBG1	ENSMPUP00000002732	ENSMPUP00000010979	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Acyl-CoA synthetase bubblegum family member 1.	0.509
ACAA1	ACSBG2	ENSMPUP00000002732	ENSMPUP00000006296	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Acyl-CoA synthetase bubblegum family member 2.	0.454
ACAA1	ACSL1	ENSMPUP00000002732	ENSMPUP00000011018	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Acyl-CoA synthetase long chain family member 1.	0.638
ACAA1	ACSL5	ENSMPUP00000002732	ENSMPUP00000002023	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Acyl-CoA synthetase long chain family member 5.	0.599
ACAA1	CPT2	ENSMPUP00000002732	ENSMPUP00000006583	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Carnitine palmitoyltransferase 2; Belongs to the carnitine/choline acetyltransferase family.	0.668
ACAA1	EHHADH	ENSMPUP00000002732	ENSMPUP00000002996	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family.	0.983
ACAA1	HMGCS1	ENSMPUP00000002732	ENSMPUP00000014322	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.983
ACAA1	HMGCS2	ENSMPUP00000002732	ENSMPUP00000001436	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.983
ACAA1	LOC101686534	ENSMPUP00000002732	ENSMPUP00000006458	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	AMP-binding domain-containing protein.	0.454
ACAA1	M3XPD9_MUSPF	ENSMPUP00000002732	ENSMPUP00000000939	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	ACB domain-containing protein.	0.661
ACAA1	M3YJH0_MUSPF	ENSMPUP00000002732	ENSMPUP00000011477	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	AMP-binding domain-containing protein.	0.595
ACAA1	M3Z713_MUSPF	ENSMPUP00000002732	ENSMPUP00000019376	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	ACB domain-containing protein.	0.526
ACAA1	ME1	ENSMPUP00000002732	ENSMPUP00000005397	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Malic enzyme.	0.413
ACAA1	ME3	ENSMPUP00000002732	ENSMPUP00000010089	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Malic enzyme.	0.413
ACAA1	SCP2	ENSMPUP00000002732	ENSMPUP00000006739	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Sterol carrier protein 2; Belongs to the thiolase-like superfamily. Thiolase family.	0.968