(119 nodes) NF-kappa B signaling pathway network (Mustela putorius)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PLCG2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1266 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (971 aa)
	IKBKG	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (412 aa)
	M3YF44_MUSPF	Ig-like domain-containing protein. (122 aa)
	LY96	Lymphocyte antigen 96. (160 aa)
	LYN	Tyrosine-protein kinase. (512 aa)
	EDAR	Ectodysplasin A receptor. (459 aa)
	IL1B	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (168 aa)
	PTGS2	Prostaglandin-endoperoxide synthase 2. (604 aa)
	TRAF2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (569 aa)
	M3YI82_MUSPF	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (215 aa)
	TNFSF13B	TNF superfamily member 13b; Belongs to the tumor necrosis factor family. (290 aa)
	ZAP70	Tyrosine-protein kinase. (616 aa)
	LTB	Lymphotoxin beta; Belongs to the tumor necrosis factor family. (247 aa)
	TNF	Tumor necrosis factor alpha; Belongs to the tumor necrosis factor family. (233 aa)
	LTA	Lymphotoxin alpha; Belongs to the tumor necrosis factor family. (204 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (511 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
	VCAM1	Vascular cell adhesion molecule 1. (739 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (577 aa)
	CARD14	Caspase recruitment domain family member 14. (1002 aa)
	IL1R1	Interleukin 1 receptor type 1. (573 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
	CARD10	Caspase recruitment domain family, member 10. (1028 aa)
	EDARADD	EDAR associated death domain. (193 aa)
	LAT	Linker for activation of T cells. (260 aa)
	TAB1	TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
	TRIM65	Tripartite motif containing 65. (517 aa)
	TRIM47	Tripartite motif containing 47. (400 aa)
	M3YRF3_MUSPF	Uncharacterized protein. (654 aa)
	CCL13	C-C motif chemokine. (98 aa)
	TNFAIP3	TNF alpha induced protein 3. (790 aa)
	M3YU74_MUSPF	C-C motif chemokine. (92 aa)
	LCK	Tyrosine-protein kinase. (509 aa)
	COIL	Coilin. (578 aa)
	TRIM25	Tripartite motif containing 25. (653 aa)
	BCL2A1	BCL2 related protein A1. (174 aa)
	UBE2I	Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
	TRAF5	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
	NFKBIA	NFKB inhibitor alpha. (314 aa)
	PRKCQ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
	TNFRSF13C	TNF receptor superfamily member 13C. (187 aa)
	MALT1	MALT1 paracaspase. (716 aa)
	RELCH	RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1214 aa)
	TNFRSF11A	TNF receptor superfamily member 11a. (603 aa)
	BCL2	BCL2 apoptosis regulator. (207 aa)
	NFKB2	Nuclear factor kappa B subunit 2. (900 aa)
	LTBR	Lymphotoxin beta receptor. (420 aa)
	TNFRSF1A	TNF receptor superfamily member 1A. (501 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
	BLNK	B cell linker. (483 aa)
	CXCL12	C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (93 aa)
	CD40	CD40 molecule. (277 aa)
	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
	M3Z217_MUSPF	Uncharacterized protein. (479 aa)
	LBP	Lipopolysaccharide binding protein. (481 aa)
	BPI	Bactericidal permeability increasing protein. (577 aa)
	BCL2L1	BCL2 like 1. (233 aa)
	M3Z2K4_MUSPF	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (391 aa)
	CARD11	Caspase recruitment domain family member 11. (1153 aa)
	ERC1	ELKS/RAB6-interacting/CAST family member 1. (886 aa)
	TAB2	TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
	M3Z7C0_MUSPF	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (215 aa)
	M3XZJ3_MUSPF	Uncharacterized protein. (140 aa)
	CCL21	SCY domain-containing protein. (137 aa)
	CCL19	C-C motif chemokine. (108 aa)
	PIAS4	Protein inhibitor of activated STAT 4. (514 aa)
	DDX58	DExD/H-box helicase 58. (937 aa)
	PLAU	Plasminogen activator, urokinase. (432 aa)
	CYLD	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (953 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
	TRAF3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (569 aa)
	TAB3	TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (715 aa)
	BTK	Tyrosine-protein kinase. (659 aa)
	CD40LG	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (260 aa)
	M3XRT3_MUSPF	Ig-like domain-containing protein. (118 aa)
	M3XRS9_MUSPF	Ig-like domain-containing protein. (117 aa)
	TNFSF11	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (321 aa)
	TLR4	Toll like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
	XIAP	X-linked inhibitor of apoptosis. (497 aa)
	GADD45A	Growth arrest and DNA damage inducible alpha. (165 aa)
	TMED7	GOLD domain-containing protein. (224 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (646 aa)
	IRAK4	Interleukin-1 receptor-associated kinase 4. (460 aa)
	CFLAR	CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (482 aa)
	M3Y650_MUSPF	Ig-like domain-containing protein. (142 aa)
	M3Y645_MUSPF	Ig-like domain-containing protein. (167 aa)
	ICAM1	Intercellular adhesion molecule 1. (589 aa)
	TIRAP	TIR domain containing adaptor protein. (227 aa)
	GADD45B	Growth arrest and DNA damage inducible beta. (160 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3057 aa)
	M3Y3E0_MUSPF	Ig-like domain-containing protein. (121 aa)
	BCL10	BCL10 immune signaling adaptor. (241 aa)
	TRADD	TNFRSF1A associated via death domain. (314 aa)
	TICAM1	TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (689 aa)
	CSNK2A2	Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. (326 aa)
	PARP1	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1013 aa)
	M3Y653_MUSPF	Protein kinase domain-containing protein. (212 aa)
	TNFSF14	TNF superfamily member 14; Belongs to the tumor necrosis factor family. (241 aa)
	BIRC2	Baculoviral IAP repeat containing 2. (570 aa)
	BIRC3	Baculoviral IAP repeat containing 3. (604 aa)
	M3Y7D3_MUSPF	DUF1968 domain-containing protein. (157 aa)
	M3Y7K5_MUSPF	Ig-like domain-containing protein. (163 aa)
	TRAV18	T cell receptor alpha variable 18. (159 aa)
	TRAF1	TNF receptor-associated factor. (415 aa)
	M3Y9A1_MUSPF	Uncharacterized protein. (364 aa)
	CD14	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (371 aa)
	GADD45G	Growth arrest and DNA damage inducible gamma. (159 aa)
	M3YAT2_MUSPF	Ig-like domain-containing protein. (186 aa)
	M3YAV2_MUSPF	Ig-like domain-containing protein. (141 aa)
	TRBV25-1	T cell receptor beta variable 25-1. (125 aa)
	M3YAY8_MUSPF	Ig-like domain-containing protein. (227 aa)
	M3YAZ8_MUSPF	Ig-like domain-containing protein. (158 aa)
	MAP3K14	Mitogen-activated protein kinase kinase kinase 14. (954 aa)
	M3YB13_MUSPF	Ig-like domain-containing protein. (159 aa)
	PIDD1	P53-induced death domain protein 1. (915 aa)
	IRAK1	Interleukin 1 receptor associated kinase 1. (696 aa)
	MAP3K7	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
	CXCL8	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	BCL2	ENSMPUP00000005920	ENSMPUP00000016413	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	BCL2 apoptosis regulator.	0.539
ATM	IKBKG	ENSMPUP00000005920	ENSMPUP00000009761	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.668
ATM	MAP3K7	ENSMPUP00000005920	ENSMPUP00000009014	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	0.406
ATM	PARP1	ENSMPUP00000005920	ENSMPUP00000004550	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.642
ATM	PIAS4	ENSMPUP00000005920	ENSMPUP00000004459	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Protein inhibitor of activated STAT 4.	0.724
ATM	PIDD1	ENSMPUP00000005920	ENSMPUP00000008961	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	P53-induced death domain protein 1.	0.887
ATM	UBE2I	ENSMPUP00000005920	ENSMPUP00000015654	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family.	0.585
BCL10	BCL2	ENSMPUP00000005407	ENSMPUP00000016413	BCL10 immune signaling adaptor.	BCL2 apoptosis regulator.	0.522
BCL10	BIRC2	ENSMPUP00000005407	ENSMPUP00000007131	BCL10 immune signaling adaptor.	Baculoviral IAP repeat containing 2.	0.499
BCL10	BIRC3	ENSMPUP00000005407	ENSMPUP00000007139	BCL10 immune signaling adaptor.	Baculoviral IAP repeat containing 3.	0.499
BCL10	CARD10	ENSMPUP00000005407	ENSMPUP00000012661	BCL10 immune signaling adaptor.	Caspase recruitment domain family, member 10.	0.663
BCL10	CARD11	ENSMPUP00000005407	ENSMPUP00000017839	BCL10 immune signaling adaptor.	Caspase recruitment domain family member 11.	0.998
BCL10	CARD14	ENSMPUP00000005407	ENSMPUP00000012112	BCL10 immune signaling adaptor.	Caspase recruitment domain family member 14.	0.655
BCL10	CHUK	ENSMPUP00000005407	ENSMPUP00000016874	BCL10 immune signaling adaptor.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.970
BCL10	CYLD	ENSMPUP00000005407	ENSMPUP00000003166	BCL10 immune signaling adaptor.	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family.	0.505
BCL10	IKBKB	ENSMPUP00000005407	ENSMPUP00000012607	BCL10 immune signaling adaptor.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.979
BCL10	IKBKG	ENSMPUP00000005407	ENSMPUP00000009761	BCL10 immune signaling adaptor.	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.937
BCL10	M3Y653_MUSPF	ENSMPUP00000005407	ENSMPUP00000006804	BCL10 immune signaling adaptor.	Protein kinase domain-containing protein.	0.750
BCL10	MALT1	ENSMPUP00000005407	ENSMPUP00000016372	BCL10 immune signaling adaptor.	MALT1 paracaspase.	0.999
BCL10	MAP3K7	ENSMPUP00000005407	ENSMPUP00000009014	BCL10 immune signaling adaptor.	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	0.954