STRINGSTRING
NLK NLK M3XLU3_MUSPF M3XLU3_MUSPF SMAD3 SMAD3 MAP2K1 MAP2K1 MAPK9 MAPK9 PRKAB2 PRKAB2 NOSTRIN NOSTRIN G6PC2 G6PC2 ATG12 ATG12 GADD45A GADD45A CDK2 CDK2 FBXO32 FBXO32 IRS1 IRS1 RNF6 RNF6 AGAP2 AGAP2 AKT1 AKT1 MAPK11 MAPK11 MAPK10 MAPK10 BNIP3 BNIP3 MAPK12 MAPK12 PRMT1 PRMT1 PRKAB1 PRKAB1 FBXO25 FBXO25 MAPK1 MAPK1 RBL2 RBL2 BRAF BRAF BCL6 BCL6 MAPK14 MAPK14 IRS4 IRS4 MAPK13 MAPK13 CCNB2 CCNB2 RNF111 RNF111 TGFB2 TGFB2 LDLRAD4 LDLRAD4 CCND1 CCND1 FOXO4 FOXO4 M3Y027_MUSPF M3Y027_MUSPF HOMER1 HOMER1 SOS2 SOS2 M3Y105_MUSPF M3Y105_MUSPF RRAD RRAD FOXG1 FOXG1 INS INS M3Y2Z6_MUSPF M3Y2Z6_MUSPF CSDE1 CSDE1 RASL11B RASL11B TSSK4 TSSK4 ATM ATM PCK2 PCK2 PIK3CD PIK3CD GABARAPL1 GABARAPL1 CDKN2D CDKN2D GADD45B GADD45B PCK1 PCK1 TGFBR1 TGFBR1 PMEPA1 PMEPA1 M3Y6L7_MUSPF M3Y6L7_MUSPF REM2 REM2 PRKAA2 PRKAA2 PLK2 PLK2 M3Y9J9_MUSPF M3Y9J9_MUSPF CCNG2 CCNG2 SNAPIN SNAPIN INSR INSR GADD45G GADD45G EGF EGF M3YB65_MUSPF M3YB65_MUSPF STK11 STK11 SMAD4 SMAD4 PRKAG2 PRKAG2 GEM GEM TGFB3 TGFB3 PIK3CB PIK3CB MAPK8 MAPK8 M3YD44_MUSPF M3YD44_MUSPF PRMT8 PRMT8 BCL2L11 BCL2L11 G6PC3 G6PC3 M3YEF8_MUSPF M3YEF8_MUSPF FOXO3 FOXO3 GABARAPL2 GABARAPL2 G6PC G6PC IL10 IL10 SGK3 SGK3 KRAS KRAS SLC2A4 SLC2A4 SOS1 SOS1 GABARAP GABARAP STAT3 STAT3 BCL6B BCL6B M3YH29_MUSPF M3YH29_MUSPF IGF1R IGF1R M3YIA6_MUSPF M3YIA6_MUSPF CAT CAT TGFBR2 TGFBR2 SIRT1 SIRT1 IGF1 IGF1 PLK1 PLK1 MAPK3 MAPK3 TMEM232 TMEM232 IKBKB IKBKB M3YNJ8_MUSPF M3YNJ8_MUSPF M3YNT9_MUSPF M3YNT9_MUSPF ARAF ARAF PLK3 PLK3 IL6 IL6 CDK3 CDK3 GRB2 GRB2 PRMT3 PRMT3 FOXJ3 FOXJ3 FOXO6 FOXO6 CCNB3 CCNB3 CDKN1A CDKN1A M3YT79_MUSPF M3YT79_MUSPF PRKAG1 PRKAG1 USP7 USP7 PIK3R1 PIK3R1 PRKAA1 PRKAA1 SGK1 SGK1 RASGEF1B RASGEF1B CREBBP CREBBP SKP2 SKP2 IL7R IL7R TSSK3 TSSK3 PDPK1 PDPK1 M3YVL3_MUSPF M3YVL3_MUSPF HOMER2 HOMER2 SUCO SUCO FASLG FASLG M3YW64_MUSPF M3YW64_MUSPF M3YWA8_MUSPF M3YWA8_MUSPF AKT3 AKT3 MYO9B MYO9B CDKN2B CDKN2B M3YX09_MUSPF M3YX09_MUSPF SETD7 SETD7 EP300 EP300 PRKAG3 PRKAG3 FOXJ2 FOXJ2 CHUK CHUK M3YZX8_MUSPF M3YZX8_MUSPF M3Z098_MUSPF M3Z098_MUSPF M3Z099_MUSPF M3Z099_MUSPF TNFSF10 TNFSF10 RAF1 RAF1 PIK3CA PIK3CA RASGEF1A RASGEF1A PLK4 PLK4 LOC101691234 LOC101691234 MDM2 MDM2 SLC35E3 SLC35E3 STK4 STK4 TGFB1 TGFB1 SGK2 SGK2 AKT2 AKT2 REM1 REM1 GRM1 GRM1 EGFR EGFR S1PR1 S1PR1 TSSK6 TSSK6 S1PR4 S1PR4 M3Z7Y4_MUSPF M3Z7Y4_MUSPF TSSK1B TSSK1B TSSK2 TSSK2 RAG1 RAG1 RAG2 RAG2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NLKMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa)
M3XLU3_MUSPFUncharacterized protein. (309 aa)
SMAD3Mothers against decapentaplegic homolog. (414 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
MAPK9Mitogen-activated protein kinase. (398 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (296 aa)
NOSTRINNitric oxide synthase trafficking. (496 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (356 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (334 aa)
FBXO32F-box protein 32. (335 aa)
IRS1Insulin receptor substrate 1. (1428 aa)
RNF6Ring finger protein 6. (683 aa)
AGAP2ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (1172 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
MAPK11Mitogen-activated protein kinase. (434 aa)
MAPK10Mitogen-activated protein kinase. (384 aa)
BNIP3BCL2 interacting protein 3. (190 aa)
MAPK12Mitogen-activated protein kinase. (287 aa)
PRMT1Protein arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (374 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
FBXO25F-box protein 25. (366 aa)
MAPK1Mitogen-activated protein kinase. (333 aa)
RBL2RB transcriptional corepressor like 2. (1139 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (715 aa)
BCL6BCL6 transcription repressor. (706 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
IRS4Insulin receptor substrate 4. (1259 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
CCNB2Cyclin B2; Belongs to the cyclin family. (397 aa)
RNF111Ring finger protein 111. (985 aa)
TGFB2Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] (414 aa)
LDLRAD4Low density lipoprotein receptor class A domain containing 4. (306 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
FOXO4Forkhead box O4. (509 aa)
M3Y027_MUSPFProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
HOMER1Homer scaffold protein 1. (354 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1281 aa)
M3Y105_MUSPFSuperoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
FOXG1Forkhead box G1. (424 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (109 aa)
M3Y2Z6_MUSPFUncharacterized protein. (189 aa)
CSDE1Cold shock domain containing E1. (784 aa)
RASL11BRAS like family 11 member B. (249 aa)
TSSK4Testis specific serine kinase 4. (339 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3057 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (620 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
GABARAPL1GABA type A receptor associated protein like 1. (123 aa)
CDKN2DCyclin-dependent kinase inhibitor 2D. (166 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (480 aa)
PMEPA1Prostate transmembrane protein, androgen induced 1. (283 aa)
M3Y6L7_MUSPFSerine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (281 aa)
REM2RRAD and GEM like GTPase 2. (342 aa)
PRKAA2Non-specific serine/threonine protein kinase. (524 aa)
PLK2Serine/threonine-protein kinase PLK. (709 aa)
M3Y9J9_MUSPFUncharacterized protein. (553 aa)
CCNG2Cyclin G2; Belongs to the cyclin family. (343 aa)
SNAPINSNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (136 aa)
INSRTyrosine-protein kinase receptor. (1352 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
M3YB65_MUSPFPX domain-containing protein. (68 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (443 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (529 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (296 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
MAPK8Mitogen-activated protein kinase. (397 aa)
M3YD44_MUSPFCyclin N-terminal domain-containing protein; Belongs to the cyclin family. (291 aa)
PRMT8Protein arginine methyltransferase 8; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (394 aa)
BCL2L11BCL2 like 11. (232 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
M3YEF8_MUSPFFOXO-TAD domain-containing protein. (399 aa)
FOXO3Forkhead box O3. (671 aa)
GABARAPL2GABA type A receptor associated protein like 2. (120 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
IL10Interleukin 10. (220 aa)
SGK3Serum/glucocorticoid regulated kinase family member 3. (355 aa)
KRASKRAS proto-oncogene, GTPase. (208 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1276 aa)
GABARAPGABA type A receptor-associated protein. (122 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
BCL6BBCL6B transcription repressor. (479 aa)
M3YH29_MUSPFUncharacterized protein. (180 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
M3YIA6_MUSPFUncharacterized protein. (333 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (445 aa)
SIRT1Sirtuin 1. (557 aa)
IGF1Insulin like growth factor 1. (153 aa)
PLK1Serine/threonine-protein kinase PLK. (542 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (399 aa)
TMEM232Transmembrane protein 232. (662 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
M3YNJ8_MUSPFUncharacterized protein. (461 aa)
M3YNT9_MUSPFProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (431 aa)
ARAFV-raf murine sarcoma 3611 viral oncoprotein-like protein. (606 aa)
PLK3Serine/threonine-protein kinase PLK. (646 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (210 aa)
CDK3Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PRMT3Protein arginine methyltransferase 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (531 aa)
FOXJ3Forkhead box J3. (636 aa)
FOXO6Forkhead box O6. (367 aa)
CCNB3Cyclin B3; Belongs to the cyclin family. (1346 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
M3YT79_MUSPFUncharacterized protein; Belongs to the cyclin family. (426 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (329 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1055 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
PRKAA1Non-specific serine/threonine protein kinase. (517 aa)
SGK1Non-specific serine/threonine protein kinase. (526 aa)
RASGEF1BRasGEF domain family member 1B. (472 aa)
CREBBPCREB binding protein. (2442 aa)
SKP2S-phase kinase associated protein 2. (436 aa)
IL7RInterleukin 7 receptor. (457 aa)
TSSK3Testis specific serine kinase 3. (225 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (531 aa)
M3YVL3_MUSPFWH1 domain-containing protein. (358 aa)
HOMER2Homer scaffold protein 2. (386 aa)
SUCOSUN domain containing ossification factor. (1250 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (275 aa)
M3YW64_MUSPFUncharacterized protein. (513 aa)
M3YWA8_MUSPFUncharacterized protein. (726 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa)
MYO9BMyosin IXB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2161 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (131 aa)
M3YX09_MUSPFUncharacterized protein. (126 aa)
SETD7Histone-lysine N-methyltransferase SETD7; Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes. (366 aa)
EP300E1A binding protein p300. (2425 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (488 aa)
FOXJ2Forkhead box J2. (567 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
M3YZX8_MUSPFUncharacterized protein. (144 aa)
M3Z098_MUSPFRho-GAP domain-containing protein. (479 aa)
M3Z099_MUSPFUncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2005 aa)
TNFSF10TNF superfamily member 10; Belongs to the tumor necrosis factor family. (320 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (644 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
RASGEF1ARasGEF domain family member 1A. (546 aa)
PLK4Polo like kinase 4. (968 aa)
LOC101691234Uncharacterized protein; Belongs to the cyclin family. (361 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (487 aa)
SLC35E3Solute carrier family 35 member E3. (317 aa)
STK4Serine/threonine kinase 4. (487 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
SGK2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (390 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
REM1GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (298 aa)
GRM1Glutamate metabotropic receptor 1. (906 aa)
EGFRReceptor protein-tyrosine kinase. (1207 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
TSSK6Testis specific serine kinase 6; Belongs to the protein kinase superfamily. (273 aa)
S1PR4Sphingosine-1-phosphate receptor 4; Belongs to the G-protein coupled receptor 1 family. (385 aa)
M3Z7Y4_MUSPFCyclin N-terminal domain-containing protein; Belongs to the cyclin family. (423 aa)
TSSK1BTestis specific serine kinase 1B; Belongs to the protein kinase superfamily. (363 aa)
TSSK2Testis specific serine kinase 2; Belongs to the protein kinase superfamily. (362 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1043 aa)
RAG2Recombination activating 2. (527 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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