STRINGSTRING
SMPD2 SMPD2 GNA11 GNA11 PPP2R1B PPP2R1B BAX BAX GNAI3 GNAI3 KNG1 KNG1 PPP2R2A PPP2R2A MAPK1 MAPK1 DEGS2 DEGS2 PPP2R5C PPP2R5C AADACL2 AADACL2 PPP2R2D PPP2R2D MAPK12 MAPK12 MAPK10 MAPK10 MAPK11 MAPK11 AKT1 AKT1 M3XRJ3_MUSPF M3XRJ3_MUSPF SPTLC3 SPTLC3 PPP2R3B PPP2R3B CERS6 CERS6 MAPK9 MAPK9 MAP2K1 MAP2K1 S1PR4 S1PR4 S1PR3 S1PR3 S1PR2 S1PR2 S1PR1 S1PR1 GNAI1 GNAI1 M3Z3D8_MUSPF M3Z3D8_MUSPF ASAH1 ASAH1 GNA12 GNA12 AKT2 AKT2 PPP2R1A PPP2R1A PIK3CA PIK3CA RAF1 RAF1 PLD1 PLD1 M3YZX8_MUSPF M3YZX8_MUSPF SGMS1 SGMS1 ASAH2 ASAH2 TNFRSF1A TNFRSF1A SGPP2 SGPP2 RAC1 RAC1 BCL2 BCL2 PPP2R3C PPP2R3C ACER2 ACER2 PPP2R5A PPP2R5A AKT3 AKT3 M3YWA8_MUSPF M3YWA8_MUSPF OPRD1 OPRD1 M3YVM5_MUSPF M3YVM5_MUSPF PDPK1 PDPK1 MAP3K5 MAP3K5 PIK3R1 PIK3R1 PRKCA PRKCA GNA13 GNA13 MS4A2 MS4A2 M3YSW7_MUSPF M3YSW7_MUSPF M3YSV8_MUSPF M3YSV8_MUSPF FCER1G FCER1G CERS5 CERS5 ABCC1 ABCC1 RHOA RHOA ROCK2 ROCK2 SPHK1 SPHK1 PPP2R5D PPP2R5D GNAI2 GNAI2 M3YNU7_MUSPF M3YNU7_MUSPF M3YNJ8_MUSPF M3YNJ8_MUSPF PLCB3 PLCB3 RAC2 RAC2 MAPK3 MAPK3 GNAQ GNAQ PPP2R5B PPP2R5B PRKCB PRKCB PRKCE PRKCE ADAMTS19 ADAMTS19 RELA RELA ADORA1 ADORA1 TNF TNF RAC3 RAC3 TRAF2 TRAF2 CERS3 CERS3 ADAMTS17 ADAMTS17 PLD2 PLD2 M3YH29_MUSPF M3YH29_MUSPF NSMAF NSMAF KRAS KRAS PPP2CB PPP2CB FYN FYN PPP2CA PPP2CA PRKCG PRKCG NFKB1 NFKB1 M3YD89_MUSPF M3YD89_MUSPF MAPK8 MAPK8 PIK3CB PIK3CB TP53 TP53 SGMS2 SGMS2 SPTLC2 SPTLC2 PLCB2 PLCB2 SRMS SRMS PTK6 PTK6 GAB2 GAB2 PPP2R2B PPP2R2B PRKCZ PRKCZ NOS3 NOS3 PPP2R2C PPP2R2C CERS4 CERS4 M3Y5U4_MUSPF M3Y5U4_MUSPF S1PR5 S1PR5 SGPP1 SGPP1 PPP2R5E PPP2R5E ACER1 ACER1 PLCB4 PLCB4 PLCB1 PLCB1 PIK3CD PIK3CD M3Y3Y6_MUSPF M3Y3Y6_MUSPF IFITM10 IFITM10 CSDE1 CSDE1 M3Y2Z6_MUSPF M3Y2Z6_MUSPF SMPD1 SMPD1 ROCK1 ROCK1 TRADD TRADD ADORA3 ADORA3 M3Y0C9_MUSPF M3Y0C9_MUSPF M3Y027_MUSPF M3Y027_MUSPF CERS2 CERS2 SGPL1 SGPL1 MAPK13 MAPK13 DEGS1 DEGS1 MAPK14 MAPK14 SPHK2 SPHK2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMPD2Sphingomyelin phosphodiesterase 2. (422 aa)
GNA11G protein subunit alpha 11. (334 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (789 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
GNAI3G protein subunit alpha i3. (354 aa)
KNG1Kininogen 1. (661 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (487 aa)
MAPK1Mitogen-activated protein kinase. (333 aa)
DEGS2Delta 4-desaturase, sphingolipid 2. (323 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (524 aa)
AADACL2Arylacetamide deacetylase like 2. (401 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (423 aa)
MAPK12Mitogen-activated protein kinase. (287 aa)
MAPK10Mitogen-activated protein kinase. (384 aa)
MAPK11Mitogen-activated protein kinase. (434 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
M3XRJ3_MUSPFUncharacterized protein. (182 aa)
SPTLC3Serine palmitoyltransferase long chain base subunit 3. (552 aa)
PPP2R3BProtein phosphatase 2 regulatory subunit B''beta. (510 aa)
CERS6Ceramide synthase 6. (435 aa)
MAPK9Mitogen-activated protein kinase. (398 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
S1PR4Sphingosine-1-phosphate receptor 4; Belongs to the G-protein coupled receptor 1 family. (385 aa)
S1PR3Sphingosine-1-phosphate receptor 3; Belongs to the G-protein coupled receptor 1 family. (378 aa)
S1PR2Sphingosine-1-phosphate receptor 2; Belongs to the G-protein coupled receptor 1 family. (352 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
GNAI1G protein subunit alpha i1. (354 aa)
M3Z3D8_MUSPFAminotran_1_2 domain-containing protein. (213 aa)
ASAH1N-acylsphingosine amidohydrolase 1; Belongs to the acid ceramidase family. (395 aa)
GNA12G protein subunit alpha 12. (305 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (590 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (644 aa)
PLD1Phospholipase. (1193 aa)
M3YZX8_MUSPFUncharacterized protein. (144 aa)
SGMS1Sphingomyelin synthase 1. (414 aa)
ASAH2Neutral ceramidase. (772 aa)
TNFRSF1ATNF receptor superfamily member 1A. (501 aa)
SGPP2Sphingosine-1-phosphate phosphatase 2. (326 aa)
RAC1Rac family small GTPase 1. (167 aa)
BCL2BCL2 apoptosis regulator. (207 aa)
PPP2R3CProtein phosphatase 2, regulatory subunit B'', gamma. (450 aa)
ACER2Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (275 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (486 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa)
M3YWA8_MUSPFUncharacterized protein. (726 aa)
OPRD1Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. (370 aa)
M3YVM5_MUSPFTLC domain-containing protein. (267 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (531 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1398 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (688 aa)
GNA13G protein subunit alpha 13. (284 aa)
MS4A2Membrane spanning 4-domains A2. (243 aa)
M3YSW7_MUSPFUncharacterized protein. (287 aa)
M3YSV8_MUSPFUncharacterized protein. (236 aa)
FCER1GFc fragment of IgE receptor Ig. (86 aa)
CERS5Ceramide synthase 5. (388 aa)
ABCC1ATP binding cassette subfamily C member 1. (1467 aa)
RHOARas homolog family member A. (193 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1389 aa)
SPHK1Sphingosine kinase 1. (386 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (676 aa)
GNAI2G protein subunit alpha i2. (355 aa)
M3YNU7_MUSPFUncharacterized protein. (294 aa)
M3YNJ8_MUSPFUncharacterized protein. (461 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1233 aa)
RAC2Rac family small GTPase 2. (192 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (399 aa)
GNAQG protein subunit alpha q. (301 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (497 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (577 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (736 aa)
ADAMTS19ADAM metallopeptidase with thrombospondin type 1 motif 19. (1113 aa)
RELARELA proto-oncogene, NF-kB subunit. (511 aa)
ADORA1Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (326 aa)
TNFTumor necrosis factor alpha; Belongs to the tumor necrosis factor family. (233 aa)
RAC3Rac family small GTPase 3. (160 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (569 aa)
CERS3Ceramide synthase 3. (447 aa)
ADAMTS17ADAM metallopeptidase with thrombospondin type 1 motif 17. (1086 aa)
PLD2Phospholipase. (867 aa)
M3YH29_MUSPFUncharacterized protein. (180 aa)
NSMAFNeutral sphingomyelinase activation associated factor. (1066 aa)
KRASKRAS proto-oncogene, GTPase. (208 aa)
PPP2CBSerine/threonine-protein phosphatase. (284 aa)
FYNTyrosine-protein kinase. (537 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
PRKCGNon-specific serine/threonine protein kinase. (569 aa)
NFKB1Nuclear factor kappa B subunit 1. (971 aa)
M3YD89_MUSPFEF-hand domain-containing protein. (499 aa)
MAPK8Mitogen-activated protein kinase. (397 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (375 aa)
SGMS2Sphingomyelin synthase 2. (365 aa)
SPTLC2Serine palmitoyltransferase long chain base subunit 2. (561 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1187 aa)
SRMSTyrosine-protein kinase. (507 aa)
PTK6Tyrosine-protein kinase. (444 aa)
GAB2GRB2 associated binding protein 2. (639 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (501 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (582 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1211 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
CERS4Ceramide synthase 4. (446 aa)
M3Y5U4_MUSPFAminotran_1_2 domain-containing protein. (469 aa)
S1PR5Sphingosine-1-phosphate receptor 5. (458 aa)
SGPP1Sphingosine-1-phosphate phosphatase 1. (448 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (467 aa)
ACER1Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (263 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1096 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
M3Y3Y6_MUSPFPeptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (375 aa)
IFITM10Interferon induced transmembrane protein 10. (232 aa)
CSDE1Cold shock domain containing E1. (784 aa)
M3Y2Z6_MUSPFUncharacterized protein. (189 aa)
SMPD1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (625 aa)
ROCK1Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1252 aa)
TRADDTNFRSF1A associated via death domain. (314 aa)
ADORA3Adenosine receptor A3; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (318 aa)
M3Y0C9_MUSPFUncharacterized protein. (218 aa)
M3Y027_MUSPFProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
CERS2Ceramide synthase 2. (387 aa)
SGPL1Sphingosine-1-phosphate lyase 1. (582 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
DEGS1Delta 4-desaturase, sphingolipid 1. (323 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
SPHK2Sphingosine kinase 2. (673 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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