STRINGSTRING
ADCY3 ADCY3 PTRHD1 PTRHD1 PDGFRB PDGFRB M3YR72_MUSPF M3YR72_MUSPF GRB2 GRB2 RHOA RHOA SPHK1 SPHK1 PDGFB PDGFB DNM1 DNM1 RRAS2 RRAS2 M3YNU7_MUSPF M3YNU7_MUSPF M3YNJ8_MUSPF M3YNJ8_MUSPF PLCB3 PLCB3 CYTH4 CYTH4 MAPK3 MAPK3 CYTH1 CYTH1 TSC1 TSC1 RALGDS RALGDS SHC4 SHC4 AVPR1B AVPR1B M3YKJ9_MUSPF M3YKJ9_MUSPF GRM2 GRM2 AGPAT2 AGPAT2 DGKQ DGKQ LOC106004699 LOC106004699 M3YHK0_MUSPF M3YHK0_MUSPF PLD2 PLD2 PLA2G4A PLA2G4A PTGFR PTGFR M3YH29_MUSPF M3YH29_MUSPF M3YH21_MUSPF M3YH21_MUSPF SOS1 SOS1 GRM5 GRM5 KRAS KRAS AGPAT1 AGPAT1 FYN FYN PLPP2 PLPP2 M3YF44_MUSPF M3YF44_MUSPF SHC2 SHC2 AGPAT3 AGPAT3 PLA2G4F PLA2G4F PIP5K1B PIP5K1B PLA2G4D PLA2G4D PLA2G4E PLA2G4E PLCG2 PLCG2 CXCL8 CXCL8 MRAS MRAS M3YCN4_MUSPF M3YCN4_MUSPF JMJD7 JMJD7 PIK3CB PIK3CB RHEB RHEB AVPR2 AVPR2 AVP AVP EGF EGF SHC3 SHC3 INSR INSR PLCB2 PLCB2 SRMS SRMS PTK6 PTK6 M3YA06_MUSPF M3YA06_MUSPF GAB2 GAB2 M3Y9A1_MUSPF M3Y9A1_MUSPF PIK3R6 PIK3R6 PIK3R5 PIK3R5 KITLG KITLG LPAR1 LPAR1 M3Y711_MUSPF M3Y711_MUSPF ADCY2 ADCY2 M3Y692_MUSPF M3Y692_MUSPF M3Y653_MUSPF M3Y653_MUSPF M3Y650_MUSPF M3Y650_MUSPF M3Y645_MUSPF M3Y645_MUSPF GRM8 GRM8 PLCB4 PLCB4 PDGFD PDGFD PLCB1 PLCB1 PIK3CD PIK3CD SHC1 SHC1 KIT KIT M3Y3E0_MUSPF M3Y3E0_MUSPF M3Y3A6_MUSPF M3Y3A6_MUSPF PDGFRA PDGFRA CSDE1 CSDE1 PDGFC PDGFC M3Y2Z6_MUSPF M3Y2Z6_MUSPF LPAR3 LPAR3 ADCY4 ADCY4 INS INS DGKZ DGKZ F2R F2R DGKD DGKD ZNF408 ZNF408 F2 F2 SOS2 SOS2 M3Y027_MUSPF M3Y027_MUSPF AGT AGT AGPAT4 AGPAT4 ADCY5 ADCY5 PIP5K1C PIP5K1C CYTH2 CYTH2 DGKI DGKI PIP5K1A PIP5K1A SPHK2 SPHK2 DGKG DGKG ADCY7 ADCY7 MAPK1 MAPK1 GRM4 GRM4 PTPN11 PTPN11 AGPAT5 AGPAT5 RRAS RRAS AKT1 AKT1 M3XRT3_MUSPF M3XRT3_MUSPF M3XRS9_MUSPF M3XRS9_MUSPF DGKH DGKH M3XR91_MUSPF M3XR91_MUSPF ADCY8 ADCY8 M3XQ42_MUSPF M3XQ42_MUSPF M3XPU1_MUSPF M3XPU1_MUSPF RALB RALB ARF1 ARF1 DGKA DGKA PTK2B PTK2B RAPGEF4 RAPGEF4 GAB1 GAB1 GRM6 GRM6 M3XMV4_MUSPF M3XMV4_MUSPF MAP2K1 MAP2K1 DGKE DGKE TSC2 TSC2 M3YW12_MUSPF M3YW12_MUSPF M3YWA8_MUSPF M3YWA8_MUSPF AKT3 AKT3 MTOR MTOR RUFY4 RUFY4 M3YYJ8_MUSPF M3YYJ8_MUSPF CYTH3 CYTH3 AVPR1A AVPR1A GRM7 GRM7 PLD1 PLD1 RAF1 RAF1 PIK3CA PIK3CA PLCG1 PLCG1 AKT2 AKT2 PDGFA PDGFA GNA12 GNA12 GRM1 GRM1 RALA RALA EGFR EGFR ADCY1 ADCY1 PIK3CG PIK3CG GRM3 GRM3 AGTR1 AGTR1 M3Z7C5_MUSPF M3Z7C5_MUSPF ARF6 ARF6 LPAR5 LPAR5 ADCY9 ADCY9 ADCY6 ADCY6 LPAR2 LPAR2 PIK3R1 PIK3R1 PRKCA PRKCA RHEBL1 RHEBL1 GNA13 GNA13 MS4A2 MS4A2 M3YSW7_MUSPF M3YSW7_MUSPF M3YSV8_MUSPF M3YSV8_MUSPF FCER1G FCER1G DGKK DGKK DGKB DGKB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1137 aa)
M3YR72_MUSPFUncharacterized protein. (542 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
RHOARas homolog family member A. (193 aa)
SPHK1Sphingosine kinase 1. (386 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (242 aa)
DNM1Dynamin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (864 aa)
RRAS2RAS related 2. (181 aa)
M3YNU7_MUSPFUncharacterized protein. (294 aa)
M3YNJ8_MUSPFUncharacterized protein. (461 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1233 aa)
CYTH4Cytohesin 4. (393 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (399 aa)
CYTH1Cytohesin 1. (401 aa)
TSC1TSC complex subunit 1. (1165 aa)
RALGDSUncharacterized protein. (888 aa)
SHC4SHC adaptor protein 4. (624 aa)
AVPR1BVasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (421 aa)
M3YKJ9_MUSPFUncharacterized protein. (156 aa)
GRM2Glutamate metabotropic receptor 2. (872 aa)
AGPAT21-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (268 aa)
DGKQDiacylglycerol kinase. (952 aa)
LOC106004699Uncharacterized protein. (178 aa)
M3YHK0_MUSPFUncharacterized protein. (183 aa)
PLD2Phospholipase. (867 aa)
PLA2G4APhospholipase A2. (749 aa)
PTGFRProstaglandin F receptor. (366 aa)
M3YH29_MUSPFUncharacterized protein. (180 aa)
M3YH21_MUSPFRas-GEF domain-containing protein. (251 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1276 aa)
GRM5Glutamate metabotropic receptor 5. (987 aa)
KRASKRAS proto-oncogene, GTPase. (208 aa)
AGPAT11-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (287 aa)
FYNTyrosine-protein kinase. (537 aa)
PLPP2Phospholipid phosphatase 2. (328 aa)
M3YF44_MUSPFIg-like domain-containing protein. (122 aa)
SHC2Uncharacterized protein. (539 aa)
AGPAT31-acylglycerol-3-phosphate O-acyltransferase 3. (376 aa)
PLA2G4FPhospholipase A2. (847 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (540 aa)
PLA2G4DPhospholipase A2. (829 aa)
PLA2G4EPhospholipase A2. (810 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1266 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
MRASMuscle RAS oncogene homolog. (208 aa)
M3YCN4_MUSPFPhospholipase A2. (783 aa)
JMJD7Jumonji domain containing 7. (316 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
RHEBRas homolog, mTORC1 binding. (179 aa)
AVPR2Vasopressin V2 receptor; Involved in renal water reabsorption. Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (370 aa)
AVPArginine vasopressin; Belongs to the vasopressin/oxytocin family. (170 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
SHC3SHC adaptor protein 3. (425 aa)
INSRTyrosine-protein kinase receptor. (1352 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1187 aa)
SRMSTyrosine-protein kinase. (507 aa)
PTK6Tyrosine-protein kinase. (444 aa)
M3YA06_MUSPFUncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (181 aa)
GAB2GRB2 associated binding protein 2. (639 aa)
M3Y9A1_MUSPFUncharacterized protein. (364 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (755 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (778 aa)
KITLGKIT ligand. (274 aa)
LPAR1Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (283 aa)
M3Y711_MUSPFacidPPc domain-containing protein. (237 aa)
ADCY2Adenylate cyclase 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (880 aa)
M3Y692_MUSPFUncharacterized protein. (362 aa)
M3Y653_MUSPFProtein kinase domain-containing protein. (212 aa)
M3Y650_MUSPFIg-like domain-containing protein. (142 aa)
M3Y645_MUSPFIg-like domain-containing protein. (167 aa)
GRM8Glutamate metabotropic receptor 8. (908 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
PDGFDPlatelet derived growth factor D. (364 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1096 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
SHC1SHC adaptor protein 1. (586 aa)
KITKIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (948 aa)
M3Y3E0_MUSPFIg-like domain-containing protein. (121 aa)
M3Y3A6_MUSPFUncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (853 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1087 aa)
CSDE1Cold shock domain containing E1. (784 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
M3Y2Z6_MUSPFUncharacterized protein. (189 aa)
LPAR3Lysophosphatidic acid receptor 3; Belongs to the G-protein coupled receptor 1 family. (354 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1105 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (109 aa)
DGKZDiacylglycerol kinase. (934 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (426 aa)
DGKDDiacylglycerol kinase. (1171 aa)
ZNF408Zinc finger protein 408. (722 aa)
F2Coagulation factor II, thrombin; Belongs to the peptidase S1 family. (602 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1281 aa)
M3Y027_MUSPFProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
AGPAT41-acylglycerol-3-phosphate O-acyltransferase 4. (378 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1018 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (653 aa)
CYTH2Uncharacterized protein. (400 aa)
DGKIDiacylglycerol kinase. (999 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (565 aa)
SPHK2Sphingosine kinase 2. (673 aa)
DGKGDiacylglycerol kinase. (790 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
MAPK1Mitogen-activated protein kinase. (333 aa)
GRM4Glutamate metabotropic receptor 4. (912 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
AGPAT51-acylglycerol-3-phosphate O-acyltransferase 5. (292 aa)
RRASRAS related. (218 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
M3XRT3_MUSPFIg-like domain-containing protein. (118 aa)
M3XRS9_MUSPFIg-like domain-containing protein. (117 aa)
DGKHDiacylglycerol kinase. (1167 aa)
M3XR91_MUSPFUncharacterized protein. (134 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa)
M3XQ42_MUSPFRas-GEF domain-containing protein. (289 aa)
M3XPU1_MUSPFRas-GEF domain-containing protein. (277 aa)
RALBRAS like proto-oncogene B. (206 aa)
ARF1ADP ribosylation factor 1; Belongs to the small GTPase superfamily. Arf family. (181 aa)
DGKADiacylglycerol kinase. (776 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (1011 aa)
GAB1GRB2 associated binding protein 1. (648 aa)
GRM6Glutamate metabotropic receptor 6. (871 aa)
M3XMV4_MUSPFUncharacterized protein. (466 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
DGKEDiacylglycerol kinase. (572 aa)
TSC2TSC complex subunit 2. (1906 aa)
M3YW12_MUSPFDynamin-type G domain-containing protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (458 aa)
M3YWA8_MUSPFUncharacterized protein. (726 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2552 aa)
RUFY4RUN and FYVE domain containing 4. (544 aa)
M3YYJ8_MUSPFG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (339 aa)
CYTH3Cytohesin 3. (351 aa)
AVPR1AVasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (421 aa)
GRM7Glutamate metabotropic receptor 7. (714 aa)
PLD1Phospholipase. (1193 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (644 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
GNA12G protein subunit alpha 12. (305 aa)
GRM1Glutamate metabotropic receptor 1. (906 aa)
RALARAS like proto-oncogene A. (206 aa)
EGFRReceptor protein-tyrosine kinase. (1207 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1130 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
GRM3Glutamate metabotropic receptor 3. (879 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (359 aa)
M3Z7C5_MUSPFG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (356 aa)
ARF6ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
LPAR5Lysophosphatidic acid receptor 5; Belongs to the G-protein coupled receptor 1 family. (367 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
LPAR2Lysophosphatidic acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (351 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (688 aa)
RHEBL1RHEB like 1. (177 aa)
GNA13G protein subunit alpha 13. (284 aa)
MS4A2Membrane spanning 4-domains A2. (243 aa)
M3YSW7_MUSPFUncharacterized protein. (287 aa)
M3YSV8_MUSPFUncharacterized protein. (236 aa)
FCER1GFc fragment of IgE receptor Ig. (86 aa)
DGKKDiacylglycerol kinase. (1250 aa)
DGKBDiacylglycerol kinase. (802 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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