STRINGSTRING
CDC45 CDC45 FZR1 FZR1 ORC4 ORC4 RBL2 RBL2 WEE2 WEE2 BUB3 BUB3 ORC6 ORC6 MCM6 MCM6 ANAPC7 ANAPC7 ANAPC5 ANAPC5 SMC3 SMC3 CDK4 CDK4 CCNA1 CCNA1 ZBTB10 ZBTB10 RB1 RB1 STAG2 STAG2 MYC MYC M3XQE0_MUSPF M3XQE0_MUSPF PRKDC PRKDC MCM4 MCM4 RAD21 RAD21 CDK2 CDK2 SMAD2 SMAD2 GADD45A GADD45A SMAD3 SMAD3 FAM126B FAM126B ORC2 ORC2 CDC25B CDC25B SMAD4 SMAD4 CCNE2 CCNE2 MCM3 MCM3 TP53 TP53 TGFB3 TGFB3 CDC16 CDC16 M3YD28_MUSPF M3YD28_MUSPF M3YD44_MUSPF M3YD44_MUSPF STAG1 STAG1 CDC25C CDC25C ORC3 ORC3 ANAPC1 ANAPC1 CDC23 CDC23 TFDP1 TFDP1 SMC1A SMC1A HDAC2 HDAC2 E2F5 E2F5 MCM7 MCM7 CDK1 CDK1 M3YIU0_MUSPF M3YIU0_MUSPF M3YJA7_MUSPF M3YJA7_MUSPF CDKN1B CDKN1B ZBTB47 ZBTB47 ATR ATR CDC14A CDC14A TFDP2 TFDP2 PLK1 PLK1 MCM5 MCM5 ABL1 ABL1 YWHAH YWHAH WEE1 WEE1 M3YP86_MUSPF M3YP86_MUSPF YWHAQ YWHAQ CCND3 CCND3 CHEK2 CHEK2 CDK3 CDK3 YWHAE YWHAE CDC20 CDC20 CCNB3 CCNB3 CDKN1A CDKN1A CDK7 CDK7 M3YT79_MUSPF M3YT79_MUSPF CDC6 CDC6 FBXW12 FBXW12 CDC25A CDC25A CREBBP CREBBP SKP2 SKP2 ANAPC2 ANAPC2 YWHAZ YWHAZ HDAC1 HDAC1 PKMYT1 PKMYT1 ZNF652 ZNF652 E2F2 E2F2 CDKN2B CDKN2B M3YX09_MUSPF M3YX09_MUSPF CDKN2A CDKN2A YWHAG YWHAG SMC1B SMC1B ZBTB17 ZBTB17 TMEM82 TMEM82 MAD2L2 MAD2L2 EP300 EP300 RBX1 RBX1 ANAPC4 ANAPC4 MYNN MYNN AP5S1 AP5S1 MCM2 MCM2 CCNA2 CCNA2 CCNB2 CCNB2 MAD2L1 MAD2L1 LOC101691234 LOC101691234 M3Z176_MUSPF M3Z176_MUSPF MDM2 MDM2 TGFB2 TGFB2 CDC7 CDC7 CCND1 CCND1 E2F3 E2F3 E2F4 E2F4 ATM ATM ESPL1 ESPL1 PCNA PCNA CHEK1 CHEK1 CDKN2D CDKN2D ANAPC10 ANAPC10 GADD45B GADD45B M3Y687_MUSPF M3Y687_MUSPF ORC1 ORC1 CDKN2C CDKN2C CUL1 CUL1 M3Y8H4_MUSPF M3Y8H4_MUSPF M3Y8I3_MUSPF M3Y8I3_MUSPF CCNH CCNH CCNE1 CCNE1 CDC27 CDC27 SNAPIN SNAPIN CDK6 CDK6 GSK3B GSK3B M3YAG0_MUSPF M3YAG0_MUSPF GADD45G GADD45G ZBTB46 ZBTB46 CDK20 CDK20 M3YB25_MUSPF M3YB25_MUSPF TGFB1 TGFB1 YWHAB YWHAB RBL1 RBL1 E2F1 E2F1 MAD1L1 MAD1L1 RAD21L1 RAD21L1 SNPH SNPH TTK TTK ORC5 ORC5 DBF4 DBF4 M3Z4W8_MUSPF M3Z4W8_MUSPF SFN SFN M3Z7E4_MUSPF M3Z7E4_MUSPF M3Z7Y4_MUSPF M3Z7Y4_MUSPF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CDC45Cell division cycle 45. (567 aa)
FZR1Fizzy and cell division cycle 20 related 1. (493 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa)
RBL2RB transcriptional corepressor like 2. (1139 aa)
WEE2Wee1-like protein kinase. (566 aa)
BUB3BUB3 mitotic checkpoint protein. (328 aa)
ORC6Origin recognition complex subunit 6. (252 aa)
MCM6DNA helicase; Belongs to the MCM family. (810 aa)
ANAPC7Anaphase promoting complex subunit 7. (598 aa)
ANAPC5Anaphase promoting complex subunit 5. (711 aa)
SMC3Structural maintenance of chromosomes protein. (1217 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (305 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (421 aa)
ZBTB10Zinc finger and BTB domain containing 10. (868 aa)
RB1RB transcriptional corepressor 1. (948 aa)
STAG2Stromal antigen 2. (1268 aa)
MYCV-myc myelocytomatosis viral oncoprotein-like protein. (453 aa)
M3XQE0_MUSPFSCD domain-containing protein. (1107 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4110 aa)
MCM4DNA helicase; Belongs to the MCM family. (920 aa)
RAD21RAD21 cohesin complex component. (631 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (334 aa)
SMAD2Mothers against decapentaplegic homolog. (495 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
SMAD3Mothers against decapentaplegic homolog. (414 aa)
FAM126BFamily with sequence similarity 126 member B. (529 aa)
ORC2Origin recognition complex subunit 2. (578 aa)
CDC25BCell division cycle 25B. (515 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
MCM3DNA helicase; Belongs to the MCM family. (808 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (375 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
CDC16Cell division cycle 16. (605 aa)
M3YD28_MUSPFUncharacterized protein. (1086 aa)
M3YD44_MUSPFCyclin N-terminal domain-containing protein; Belongs to the cyclin family. (291 aa)
STAG1Stromal antigen 1. (1258 aa)
CDC25CCell division cycle 25C. (491 aa)
ORC3Origin recognition complex subunit 3. (711 aa)
ANAPC1Anaphase promoting complex subunit 1. (1944 aa)
CDC23Cell division cycle 23. (590 aa)
TFDP1Transcription factor. (410 aa)
SMC1AStructural maintenance of chromosomes protein. (1233 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (469 aa)
E2F5E2F transcription factor 5. (332 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (672 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
M3YIU0_MUSPFRING-type domain-containing protein. (84 aa)
M3YJA7_MUSPF14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (228 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (199 aa)
ZBTB47Zinc finger and BTB domain containing 47. (781 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa)
CDC14ACell division cycle 14A. (610 aa)
TFDP2Transcription factor. (447 aa)
PLK1Serine/threonine-protein kinase PLK. (542 aa)
MCM5DNA helicase; Belongs to the MCM family. (736 aa)
ABL1Tyrosine-protein kinase. (1150 aa)
YWHAHTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (246 aa)
WEE1Wee1-like protein kinase. (450 aa)
M3YP86_MUSPFUncharacterized protein. (201 aa)
YWHAQTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta; Belongs to the 14-3-3 family. (245 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (294 aa)
CHEK2Checkpoint kinase 2. (544 aa)
CDK3Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (251 aa)
CDC20Cell division cycle 20-like protein. (499 aa)
CCNB3Cyclin B3; Belongs to the cyclin family. (1346 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
CDK7Cyclin dependent kinase 7; Belongs to the protein kinase superfamily. (349 aa)
M3YT79_MUSPFUncharacterized protein; Belongs to the cyclin family. (426 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (558 aa)
FBXW12F-box and WD repeat domain containing 12. (469 aa)
CDC25ACell division cycle 25A. (476 aa)
CREBBPCREB binding protein. (2442 aa)
SKP2S-phase kinase associated protein 2. (436 aa)
ANAPC2Anaphase promoting complex subunit 2; Belongs to the cullin family. (818 aa)
YWHAZTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (245 aa)
HDAC1Histone deacetylase 1. (482 aa)
PKMYT1Protein kinase, membrane associated tyrosine/threonine 1; Belongs to the protein kinase superfamily. (481 aa)
ZNF652Zinc finger protein 652. (612 aa)
E2F2E2F transcription factor 2. (440 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (131 aa)
M3YX09_MUSPFUncharacterized protein. (126 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (152 aa)
YWHAGTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family. (247 aa)
SMC1BStructural maintenance of chromosomes protein. (1207 aa)
ZBTB17Zinc finger and BTB domain containing 17. (667 aa)
TMEM82Transmembrane protein 82. (348 aa)
MAD2L2Mitotic arrest deficient 2 like 2. (211 aa)
EP300E1A binding protein p300. (2425 aa)
RBX1Ring-box 1. (108 aa)
ANAPC4Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (807 aa)
MYNNMyoneurin. (610 aa)
AP5S1Adaptor related protein complex 5 subunit sigma 1. (201 aa)
MCM2DNA helicase; Belongs to the MCM family. (903 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (432 aa)
CCNB2Cyclin B2; Belongs to the cyclin family. (397 aa)
MAD2L1Mitotic arrest deficient 2 like 1. (205 aa)
LOC101691234Uncharacterized protein; Belongs to the cyclin family. (361 aa)
M3Z176_MUSPF14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (221 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (487 aa)
TGFB2Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] (414 aa)
CDC7Cell division cycle 7. (575 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
E2F3E2F transcription factor 3. (340 aa)
E2F4E2F transcription factor 4. (403 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3057 aa)
ESPL1Extra spindle pole bodies like 1, separase. (2111 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
CHEK1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa)
CDKN2DCyclin-dependent kinase inhibitor 2D. (166 aa)
ANAPC10Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
M3Y687_MUSPFUncharacterized protein. (493 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (862 aa)
CDKN2CCyclin dependent kinase inhibitor 2C. (168 aa)
CUL1Cullin 1; Belongs to the cullin family. (677 aa)
M3Y8H4_MUSPFWD_REPEATS_REGION domain-containing protein. (146 aa)
M3Y8I3_MUSPFWD_REPEATS_REGION domain-containing protein. (118 aa)
CCNHCyclin H; Belongs to the cyclin family. (323 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (410 aa)
CDC27Cell division cycle 27. (825 aa)
SNAPINSNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (136 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (420 aa)
M3YAG0_MUSPFBUB1 N-terminal domain-containing protein. (1062 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
ZBTB46Zinc finger and BTB domain containing 46. (590 aa)
CDK20Cyclin dependent kinase 20; Belongs to the protein kinase superfamily. (346 aa)
M3YB25_MUSPFUncharacterized protein. (467 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (204 aa)
RBL1RB transcriptional corepressor like 1. (1066 aa)
E2F1E2F transcription factor 1. (354 aa)
MAD1L1Mitotic arrest deficient 1 like 1. (737 aa)
RAD21L1RAD21 cohesin complex component like 1. (553 aa)
SNPHSyntaphilin. (493 aa)
TTKTTK protein kinase. (856 aa)
ORC5Origin recognition complex subunit 5. (435 aa)
DBF4DBF4 zinc finger. (683 aa)
M3Z4W8_MUSPFUncharacterized protein; Belongs to the SKP1 family. (163 aa)
SFN14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (255 aa)
M3Z7E4_MUSPFUncharacterized protein. (1085 aa)
M3Z7Y4_MUSPFCyclin N-terminal domain-containing protein; Belongs to the cyclin family. (423 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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