STRINGSTRING
MAP3K14 MAP3K14 CFLAR CFLAR CASP10 CASP10 CASP8 CASP8 MAP2K1 MAP2K1 RIPK1 RIPK1 MAPK9 MAPK9 GADD45A GADD45A M3XQ63_MUSPF M3XQ63_MUSPF XIAP XIAP M3XR07_MUSPF M3XR07_MUSPF CTSB CTSB DDIT3 DDIT3 M3XSD0_MUSPF M3XSD0_MUSPF CASP7 CASP7 AKT1 AKT1 PTPN13 PTPN13 MAPK10 MAPK10 M3XTE0_MUSPF M3XTE0_MUSPF DAXX DAXX BAK1 BAK1 ITPR3 ITPR3 LOC101673308 LOC101673308 EXOG EXOG HTRA1 HTRA1 MAPK1 MAPK1 M3XVS8_MUSPF M3XVS8_MUSPF BAX BAX CTSF CTSF NTRK1 NTRK1 TUBA3D TUBA3D M3XXX1_MUSPF M3XXX1_MUSPF CAPN2 CAPN2 PRF1 PRF1 CTSK CTSK C7orf31 C7orf31 CAPN13 CAPN13 CTSS CTSS CAPN14 CAPN14 PARP1 PARP1 CAPN9 CAPN9 MCL1 MCL1 FADD FADD M3Y027_MUSPF M3Y027_MUSPF LMNA LMNA M3Y0R3_MUSPF M3Y0R3_MUSPF M3Y0Z9_MUSPF M3Y0Z9_MUSPF RRAD RRAD TRADD TRADD GZMB GZMB CTSO CTSO M3Y2Z6_MUSPF M3Y2Z6_MUSPF CSDE1 CSDE1 M3Y3B0_MUSPF M3Y3B0_MUSPF M3Y3D0_MUSPF M3Y3D0_MUSPF ATM ATM IFITM10 IFITM10 M3Y3Y6_MUSPF M3Y3Y6_MUSPF PIK3CD PIK3CD M3Y4Q2_MUSPF M3Y4Q2_MUSPF FAS FAS GADD45B GADD45B LMNB2 LMNB2 CTSV CTSV CASP2 CASP2 CTSZ CTSZ EIF2S1 EIF2S1 BIRC2 BIRC2 BIRC3 BIRC3 DFFB DFFB DAB2IP DAB2IP M3Y818_MUSPF M3Y818_MUSPF TRAF1 TRAF1 HTRA2 HTRA2 GADD45G GADD45G TP53 TP53 GEM GEM PIDD1 PIDD1 PIK3CB PIK3CB MAPK8 MAPK8 FOS FOS EIF2AK3 EIF2AK3 NFKB1 NFKB1 BCL2L11 BCL2L11 M3YDY5_MUSPF M3YDY5_MUSPF CAPN3 CAPN3 IKBKG IKBKG M3YEN4_MUSPF M3YEN4_MUSPF KRAS KRAS CTSC CTSC ITPR2 ITPR2 M3YH29_MUSPF M3YH29_MUSPF TRAF2 TRAF2 CASP3 CASP3 CENPU CENPU M3YIF3_MUSPF M3YIF3_MUSPF M3YIU7_MUSPF M3YIU7_MUSPF TNF TNF CTSW CTSW APAF1 APAF1 M3YJF2_MUSPF M3YJF2_MUSPF ACTG1 ACTG1 RELA RELA PARP3 PARP3 LMNB1 LMNB1 M3YL64_MUSPF M3YL64_MUSPF ERN2 ERN2 CAPN1 CAPN1 CSF2RB CSF2RB CAPN11 CAPN11 MAPK3 MAPK3 IKBKB IKBKB M3YMU3_MUSPF M3YMU3_MUSPF SPTA1 SPTA1 BAD BAD M3YNJ8_MUSPF M3YNJ8_MUSPF ENDOG ENDOG SPTAN1 SPTAN1 PPP1R14B PPP1R14B BIRC5 BIRC5 PARP4 PARP4 M3YPM9_MUSPF M3YPM9_MUSPF HPS5 HPS5 M3YT37_MUSPF M3YT37_MUSPF M3YT38_MUSPF M3YT38_MUSPF PIK3R1 PIK3R1 ERN1 ERN1 MAP3K5 MAP3K5 M3YU21_MUSPF M3YU21_MUSPF TEX14 TEX14 M3YV15_MUSPF M3YV15_MUSPF PDPK1 PDPK1 CTSH CTSH BCL2A1 BCL2A1 SUCO SUCO FASLG FASLG M3YWA8_MUSPF M3YWA8_MUSPF AKT3 AKT3 M3YWQ4_MUSPF M3YWQ4_MUSPF ACTL8 ACTL8 NFKBIA NFKBIA TUBAL3 TUBAL3 CASP9 CASP9 DFFA DFFA BCL2 BCL2 TUBA4A TUBA4A ACTB ACTB TNFRSF1A TNFRSF1A CHUK CHUK ITPR1 ITPR1 M3Z036_MUSPF M3Z036_MUSPF TNFSF10 TNFSF10 RAF1 RAF1 PIK3CA PIK3CA AIFM1 AIFM1 M3Z171_MUSPF M3Z171_MUSPF AKT2 AKT2 CAPN12 CAPN12 BCL2L1 BCL2L1 REM1 REM1 TUBA8 TUBA8 PARP2 PARP2 M3Z4Y0_MUSPF M3Z4Y0_MUSPF NGF NGF M3Z7F2_MUSPF M3Z7F2_MUSPF JUN JUN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (954 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (482 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (545 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (484 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (646 aa)
MAPK9Mitogen-activated protein kinase. (398 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
M3XQ63_MUSPFUncharacterized protein. (390 aa)
XIAPX-linked inhibitor of apoptosis. (497 aa)
M3XR07_MUSPFUncharacterized protein; Belongs to the actin family. (362 aa)
CTSBCathepsin B; Belongs to the peptidase C1 family. (339 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
M3XSD0_MUSPFUncharacterized protein. (237 aa)
CASP7Caspase 7; Belongs to the peptidase C14A family. (301 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PTPN13Protein tyrosine phosphatase non-receptor type 13. (2486 aa)
MAPK10Mitogen-activated protein kinase. (384 aa)
M3XTE0_MUSPFUncharacterized protein; Belongs to the actin family. (348 aa)
DAXXDeath domain associated protein. (779 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2609 aa)
LOC101673308Uncharacterized protein; Belongs to the peptidase C14A family. (369 aa)
EXOGExo/endonuclease G. (368 aa)
HTRA1HtrA serine peptidase 1. (422 aa)
MAPK1Mitogen-activated protein kinase. (333 aa)
M3XVS8_MUSPFCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
CTSFCathepsin F; Belongs to the peptidase C1 family. (459 aa)
NTRK1Tyrosine-protein kinase receptor. (727 aa)
TUBA3DTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
M3XXX1_MUSPFCalpain catalytic domain-containing protein; Belongs to the peptidase C2 family. (417 aa)
CAPN2Calpain 2; Belongs to the peptidase C2 family. (830 aa)
PRF1Perforin 1. (602 aa)
CTSKCathepsin K; Belongs to the peptidase C1 family. (339 aa)
C7orf31Chromosome 7 open reading frame 31. (589 aa)
CAPN13Calpain 13; Belongs to the peptidase C2 family. (667 aa)
CTSSCathepsin S; Belongs to the peptidase C1 family. (342 aa)
CAPN14Calpain 14; Belongs to the peptidase C2 family. (782 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1013 aa)
CAPN9Calpain 9; Belongs to the peptidase C2 family. (691 aa)
MCL1MCL1 apoptosis regulator, BCL2 family member. (350 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (216 aa)
M3Y027_MUSPFProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
LMNALamin A/C; Belongs to the intermediate filament family. (665 aa)
M3Y0R3_MUSPFUncharacterized protein. (201 aa)
M3Y0Z9_MUSPFUncharacterized protein. (127 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
TRADDTNFRSF1A associated via death domain. (314 aa)
GZMBGranzyme B; Belongs to the peptidase S1 family. (258 aa)
CTSOCathepsin O; Belongs to the peptidase C1 family. (279 aa)
M3Y2Z6_MUSPFUncharacterized protein. (189 aa)
CSDE1Cold shock domain containing E1. (784 aa)
M3Y3B0_MUSPFUncharacterized protein; Belongs to the peptidase C1 family. (333 aa)
M3Y3D0_MUSPFUncharacterized protein; Belongs to the peptidase C1 family. (334 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3057 aa)
IFITM10Interferon induced transmembrane protein 10. (232 aa)
M3Y3Y6_MUSPFPeptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (375 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
M3Y4Q2_MUSPFUncharacterized protein; Belongs to the peptidase C14A family. (422 aa)
FASFas cell surface death receptor. (311 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
LMNB2Lamin B2; Belongs to the intermediate filament family. (614 aa)
CTSVCathepsin V; Belongs to the peptidase C1 family. (335 aa)
CASP2Caspase 2; Belongs to the peptidase C14A family. (452 aa)
CTSZCathepsin Z; Belongs to the peptidase C1 family. (300 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit alpha. (315 aa)
BIRC2Baculoviral IAP repeat containing 2. (570 aa)
BIRC3Baculoviral IAP repeat containing 3. (604 aa)
DFFBDNA fragmentation factor subunit beta. (301 aa)
DAB2IPDAB2 interacting protein. (1112 aa)
M3Y818_MUSPFTubulin_C domain-containing protein; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (272 aa)
TRAF1TNF receptor-associated factor. (415 aa)
HTRA2HtrA serine peptidase 2. (533 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (375 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (296 aa)
PIDD1P53-induced death domain protein 1. (915 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
MAPK8Mitogen-activated protein kinase. (397 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (446 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1065 aa)
NFKB1Nuclear factor kappa B subunit 1. (971 aa)
BCL2L11BCL2 like 11. (232 aa)
M3YDY5_MUSPFUncharacterized protein. (126 aa)
CAPN3Calpain 3; Belongs to the peptidase C2 family. (821 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (412 aa)
M3YEN4_MUSPFBZIP domain-containing protein. (358 aa)
KRASKRAS proto-oncogene, GTPase. (208 aa)
CTSCCathepsin C; Belongs to the peptidase C1 family. (463 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
M3YH29_MUSPFUncharacterized protein. (180 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (569 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
CENPUCentromere protein U. (446 aa)
M3YIF3_MUSPFTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (406 aa)
M3YIU7_MUSPFTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (442 aa)
TNFTumor necrosis factor alpha; Belongs to the tumor necrosis factor family. (233 aa)
CTSWCathepsin W; Belongs to the peptidase C1 family. (379 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1250 aa)
M3YJF2_MUSPFUncharacterized protein. (140 aa)
ACTG1Actin gamma 1. (375 aa)
RELARELA proto-oncogene, NF-kB subunit. (511 aa)
PARP3Poly [ADP-ribose] polymerase. (531 aa)
LMNB1Lamin B1; Belongs to the intermediate filament family. (646 aa)
M3YL64_MUSPFTubulin_C domain-containing protein; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (318 aa)
ERN2Endoplasmic reticulum to nucleus signaling 2. (926 aa)
CAPN1Calpain 1, large subunit; Belongs to the peptidase C2 family. (715 aa)
CSF2RBColony stimulating factor 2 receptor beta common subunit. (902 aa)
CAPN11Calpain 11; Belongs to the peptidase C2 family. (712 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (399 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
M3YMU3_MUSPFMIR domain-containing protein. (78 aa)
SPTA1Spectrin alpha, erythrocytic 1. (2434 aa)
BADBCL2 associated agonist of cell death. (168 aa)
M3YNJ8_MUSPFUncharacterized protein. (461 aa)
ENDOGEndonuclease. (237 aa)
SPTAN1Spectrin alpha, non-erythrocytic 1. (2477 aa)
PPP1R14BProtein phosphatase 1 regulatory inhibitor subunit 14B. (145 aa)
BIRC5Baculoviral IAP repeat containing 5. (142 aa)
PARP4Poly [ADP-ribose] polymerase. (1556 aa)
M3YPM9_MUSPFBZIP domain-containing protein. (351 aa)
HPS5Hermansky-Pudlak syndrome 5 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. (1129 aa)
M3YT37_MUSPFTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (223 aa)
M3YT38_MUSPFTubulin_C domain-containing protein; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (452 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (975 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1398 aa)
M3YU21_MUSPFUncharacterized protein; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (409 aa)
TEX14Testis expressed 14, intercellular bridge forming factor. (1534 aa)
M3YV15_MUSPFSeptin-type G domain-containing protein; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (1004 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (531 aa)
CTSHCathepsin H; Belongs to the peptidase C1 family. (335 aa)
BCL2A1BCL2 related protein A1. (174 aa)
SUCOSUN domain containing ossification factor. (1250 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (275 aa)
M3YWA8_MUSPFUncharacterized protein. (726 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa)
M3YWQ4_MUSPFUncharacterized protein; Belongs to the actin family. (338 aa)
ACTL8Actin like 8; Belongs to the actin family. (366 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
TUBAL3Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (494 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (451 aa)
DFFADNA fragmentation factor subunit alpha. (327 aa)
BCL2BCL2 apoptosis regulator. (207 aa)
TUBA4ATubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (448 aa)
ACTBActin beta. (375 aa)
TNFRSF1ATNF receptor superfamily member 1A. (501 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2709 aa)
M3Z036_MUSPFUncharacterized protein; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (434 aa)
TNFSF10TNF superfamily member 10; Belongs to the tumor necrosis factor family. (320 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (644 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
AIFM1Apoptosis inducing factor mitochondria associated 1. (421 aa)
M3Z171_MUSPFUncharacterized protein. (125 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
CAPN12Calpain 12; Belongs to the peptidase C2 family. (723 aa)
BCL2L1BCL2 like 1. (233 aa)
REM1GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (298 aa)
TUBA8Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (456 aa)
PARP2Poly [ADP-ribose] polymerase. (567 aa)
M3Z4Y0_MUSPFCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (241 aa)
M3Z7F2_MUSPFTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
Server load: low (26%) [HD]