STRINGSTRING
CREB3L2 CREB3L2 M3YNJ8_MUSPF M3YNJ8_MUSPF M3YMK5_MUSPF M3YMK5_MUSPF M3YMK1_MUSPF M3YMK1_MUSPF EIF4E1B EIF4E1B TSC1 TSC1 SESN3 SESN3 IGF1 IGF1 SIRT1 SIRT1 RPTOR RPTOR CAT CAT RELA RELA ADIPOR1 ADIPOR1 M3YIA6_MUSPF M3YIA6_MUSPF EHMT2 EHMT2 IGF1R IGF1R M3YH29_MUSPF M3YH29_MUSPF ATF6B ATF6B KRAS KRAS EIF4EBP1 EIF4EBP1 M3YEN4_MUSPF M3YEN4_MUSPF SESN1 SESN1 FOXO3 FOXO3 M3YEF8_MUSPF M3YEF8_MUSPF ATG5 ATG5 NFKB1 NFKB1 PIK3CB PIK3CB TP53 TP53 PRKAG2 PRKAG2 RHEB RHEB STK11 STK11 INSR INSR CREB3L4 CREB3L4 ATG101 ATG101 PRKAA2 PRKAA2 ADCY2 ADCY2 RB1CC1 RB1CC1 PIK3CD PIK3CD PRKACB PRKACB CSDE1 CSDE1 M3Y2Z6_MUSPF M3Y2Z6_MUSPF ADCY4 ADCY4 CREB3L1 CREB3L1 INS INS ATG13 ATG13 CREB3 CREB3 M3Y1G8_MUSPF M3Y1G8_MUSPF M3Y105_MUSPF M3Y105_MUSPF CREB5 CREB5 CREB3L3 CREB3L3 ADCY5 ADCY5 IRS4 IRS4 RPS6KB2 RPS6KB2 ADIPOQ ADIPOQ BAX BAX ADCY7 ADCY7 PRKACA PRKACA PRKAB1 PRKAB1 ULK1 ULK1 AKT1S1 AKT1S1 AKT1 AKT1 M3XSH0_MUSPF M3XSH0_MUSPF KL KL ADCY8 ADCY8 IRS1 IRS1 PRKAB2 PRKAB2 CREB1 CREB1 M3Z8B6_MUSPF M3Z8B6_MUSPF M3Z5X1_MUSPF M3Z5X1_MUSPF ADCY1 ADCY1 ADIPOR2 ADIPOR2 AKT2 AKT2 PIK3CA PIK3CA PPARG PPARG APPL1 APPL1 PPARGC1A PPARGC1A PRKAG3 PRKAG3 MTOR MTOR AKT3 AKT3 M3YWA8_MUSPF M3YWA8_MUSPF M3YW64_MUSPF M3YW64_MUSPF SESN2 SESN2 TSC2 TSC2 EHMT1 EHMT1 RPS6KB1 RPS6KB1 ADCY9 ADCY9 PRKAA1 PRKAA1 ADCY6 ADCY6 PIK3R1 PIK3R1 PRKAG1 PRKAG1 RHEBL1 RHEBL1 ADCY3 ADCY3 PTRHD1 PTRHD1 ATF2 ATF2 M3YPM9_MUSPF M3YPM9_MUSPF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
M3YNJ8_MUSPFUncharacterized protein. (461 aa)
M3YMK5_MUSPFProtein kinase domain-containing protein. (185 aa)
M3YMK1_MUSPFProtein kinase domain-containing protein. (105 aa)
EIF4E1BEukaryotic translation initiation factor 4E family member 1B; Belongs to the eukaryotic initiation factor 4E family. (263 aa)
TSC1TSC complex subunit 1. (1165 aa)
SESN3Sestrin 3. (495 aa)
IGF1Insulin like growth factor 1. (153 aa)
SIRT1Sirtuin 1. (557 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1244 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
RELARELA proto-oncogene, NF-kB subunit. (511 aa)
ADIPOR1Adiponectin receptor 1. (375 aa)
M3YIA6_MUSPFUncharacterized protein. (333 aa)
EHMT2Euchromatic histone lysine methyltransferase 2. (1270 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
M3YH29_MUSPFUncharacterized protein. (180 aa)
ATF6BActivating transcription factor 6 beta. (707 aa)
KRASKRAS proto-oncogene, GTPase. (208 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (118 aa)
M3YEN4_MUSPFBZIP domain-containing protein. (358 aa)
SESN1Sestrin 1. (551 aa)
FOXO3Forkhead box O3. (671 aa)
M3YEF8_MUSPFFOXO-TAD domain-containing protein. (399 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
NFKB1Nuclear factor kappa B subunit 1. (971 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (375 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (529 aa)
RHEBRas homolog, mTORC1 binding. (179 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (443 aa)
INSRTyrosine-protein kinase receptor. (1352 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (386 aa)
ATG101Autophagy related 101. (218 aa)
PRKAA2Non-specific serine/threonine protein kinase. (524 aa)
ADCY2Adenylate cyclase 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (880 aa)
RB1CC1RB1 inducible coiled-coil 1. (1593 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
CSDE1Cold shock domain containing E1. (784 aa)
M3Y2Z6_MUSPFUncharacterized protein. (189 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1105 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (520 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (109 aa)
ATG13Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (550 aa)
CREB3cAMP responsive element binding protein 3. (353 aa)
M3Y1G8_MUSPFUncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (245 aa)
M3Y105_MUSPFSuperoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
CREB5cAMP responsive element binding protein 5. (275 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (473 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1018 aa)
IRS4Insulin receptor substrate 4. (1259 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (479 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
ULK1Unc-51 like autophagy activating kinase 1. (970 aa)
AKT1S1AKT1 substrate 1. (285 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
M3XSH0_MUSPFUncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (219 aa)
KLKlotho. (987 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa)
IRS1Insulin receptor substrate 1. (1428 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (296 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
M3Z8B6_MUSPFUncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (216 aa)
M3Z5X1_MUSPFUncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (217 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1130 aa)
ADIPOR2Adiponectin receptor 2. (385 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (475 aa)
APPL1Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (672 aa)
PPARGC1APPARG coactivator 1 alpha. (796 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (488 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2552 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa)
M3YWA8_MUSPFUncharacterized protein. (726 aa)
M3YW64_MUSPFUncharacterized protein. (513 aa)
SESN2Sestrin 2. (479 aa)
TSC2TSC complex subunit 2. (1906 aa)
EHMT1Euchromatic histone lysine methyltransferase 1. (1268 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
PRKAA1Non-specific serine/threonine protein kinase. (517 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (329 aa)
RHEBL1RHEB like 1. (177 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
M3YPM9_MUSPFBZIP domain-containing protein. (351 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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