(35 nodes) Apoptosis - multiple species network (Mustela putorius)

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second shell of interactors

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proteins of unknown 3D structure

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Predicted Interactions

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protein homology

Your Input:
	NGFR	Nerve growth factor receptor. (429 aa)
	BOK	BCL2 family apoptosis regulator BOK. (213 aa)
	CASP8	Caspase 8; Belongs to the peptidase C14A family. (484 aa)
	MAPK9	Mitogen-activated protein kinase. (398 aa)
	M3XPB9_MUSPF	DUF4203 domain-containing protein. (350 aa)
	XIAP	X-linked inhibitor of apoptosis. (497 aa)
	M3XSD0_MUSPF	Uncharacterized protein. (237 aa)
	CASP7	Caspase 7; Belongs to the peptidase C14A family. (301 aa)
	MAPK10	Mitogen-activated protein kinase. (384 aa)
	BAK1	BCL2 antagonist/killer 1. (211 aa)
	M3XVS8_MUSPF	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	BAX	BCL2 associated X, apoptosis regulator. (192 aa)
	C7orf31	Chromosome 7 open reading frame 31. (589 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (216 aa)
	M3Y0R3_MUSPF	Uncharacterized protein. (201 aa)
	BIRC6	Baculoviral IAP repeat containing 6. (4785 aa)
	BIRC2	Baculoviral IAP repeat containing 2. (570 aa)
	M3Z4Y0_MUSPF	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	BCL2L1	BCL2 like 1. (233 aa)
	TNFRSF1A	TNF receptor superfamily member 1A. (501 aa)
	TMEM198	Transmembrane protein 198. (360 aa)
	BCL2	BCL2 apoptosis regulator. (207 aa)
	CASP9	Caspase 9; Belongs to the peptidase C14A family. (451 aa)
	BIRC3	Baculoviral IAP repeat containing 3. (604 aa)
	BIRC7	Baculoviral IAP repeat containing 7. (300 aa)
	HTRA2	HtrA serine peptidase 2. (533 aa)
	MAPK8	Mitogen-activated protein kinase. (397 aa)
	BCL2L11	BCL2 like 11. (232 aa)
	BECN1	Beclin 1. (448 aa)
	CASP3	Caspase 3; Belongs to the peptidase C14A family. (277 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1250 aa)
	BIRC5	Baculoviral IAP repeat containing 5. (142 aa)
	TEX14	Testis expressed 14, intercellular bridge forming factor. (1534 aa)
	M3YV15_MUSPF	Septin-type G domain-containing protein; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (1004 aa)
	BECN2	Beclin 2. (437 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APAF1	BAK1	ENSMPUP00000011357	ENSMPUP00000002412	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 antagonist/killer 1.	0.763
APAF1	BAX	ENSMPUP00000011357	ENSMPUP00000003276	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 associated X, apoptosis regulator.	0.671
APAF1	BCL2	ENSMPUP00000011357	ENSMPUP00000016413	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 apoptosis regulator.	0.905
APAF1	BCL2L1	ENSMPUP00000011357	ENSMPUP00000017791	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 like 1.	0.760
APAF1	BCL2L11	ENSMPUP00000011357	ENSMPUP00000009390	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 like 11.	0.402
APAF1	BIRC2	ENSMPUP00000011357	ENSMPUP00000007131	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Baculoviral IAP repeat containing 2.	0.703
APAF1	BIRC3	ENSMPUP00000011357	ENSMPUP00000007139	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Baculoviral IAP repeat containing 3.	0.703
APAF1	BIRC5	ENSMPUP00000011357	ENSMPUP00000013150	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Baculoviral IAP repeat containing 5.	0.703
APAF1	BIRC6	ENSMPUP00000011357	ENSMPUP00000005239	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Baculoviral IAP repeat containing 6.	0.849
APAF1	BIRC7	ENSMPUP00000011357	ENSMPUP00000008063	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Baculoviral IAP repeat containing 7.	0.696
APAF1	BOK	ENSMPUP00000011357	ENSMPUP00000000176	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 family apoptosis regulator BOK.	0.663
APAF1	CASP3	ENSMPUP00000011357	ENSMPUP00000010994	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 3; Belongs to the peptidase C14A family.	0.993
APAF1	CASP7	ENSMPUP00000011357	ENSMPUP00000001996	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 7; Belongs to the peptidase C14A family.	0.897
APAF1	CASP8	ENSMPUP00000011357	ENSMPUP00000000237	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 8; Belongs to the peptidase C14A family.	0.936
APAF1	CASP9	ENSMPUP00000011357	ENSMPUP00000016239	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 9; Belongs to the peptidase C14A family.	0.999
APAF1	FADD	ENSMPUP00000011357	ENSMPUP00000004665	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.653
APAF1	HTRA2	ENSMPUP00000011357	ENSMPUP00000008075	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	HtrA serine peptidase 2.	0.533
APAF1	M3XPB9_MUSPF	ENSMPUP00000011357	ENSMPUP00000000919	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	DUF4203 domain-containing protein.	0.785
APAF1	M3XSD0_MUSPF	ENSMPUP00000011357	ENSMPUP00000001980	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein.	0.770
APAF1	M3XVS8_MUSPF	ENSMPUP00000011357	ENSMPUP00000003178	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.992