STRINGSTRING
BTK BTK MITF MITF TNFRSF1A TNFRSF1A NFKB2 NFKB2 NFATC1 NFATC1 TNFRSF11A TNFRSF11A RELCH RELCH NFKBIA NFKBIA NCF1 NCF1 AKT3 AKT3 M3YWA8_MUSPF M3YWA8_MUSPF LCK LCK NOXA1 NOXA1 IFNGR1 IFNGR1 PIK3R1 PIK3R1 MAP2K6 MAP2K6 CSF1R CSF1R GRB2 GRB2 TREML1 TREML1 TREM2 TREM2 TAB1 TAB1 M3YNJ8_MUSPF M3YNJ8_MUSPF LCP2 LCP2 IKBKB IKBKB M3YMK5_MUSPF M3YMK5_MUSPF M3YMK1_MUSPF M3YMK1_MUSPF MAPK3 MAPK3 NCF4 NCF4 STAT1 STAT1 IL1R1 IL1R1 TGFBR2 TGFBR2 TRAF6 TRAF6 NCF2 NCF2 RELA RELA FOSL1 FOSL1 TNF TNF TRAF2 TRAF2 MAP2K1 MAP2K1 CREB1 CREB1 MAPK9 MAPK9 SQSTM1 SQSTM1 JAK1 JAK1 TNFRSF11B TNFRSF11B M3XQ69_MUSPF M3XQ69_MUSPF IFNAR1 IFNAR1 IFNGR2 IFNGR2 STAT2 STAT2 TNFSF11 TNFSF11 AKT1 AKT1 M3XSU3_MUSPF M3XSU3_MUSPF CHUK CHUK M3XSV5_MUSPF M3XSV5_MUSPF NOX1 NOX1 MAPK11 MAPK11 MAPK10 MAPK10 MAPK12 MAPK12 MAPK1 MAPK1 CYLD CYLD M3XWH1_MUSPF M3XWH1_MUSPF M3XWH7_MUSPF M3XWH7_MUSPF PPP3CB PPP3CB PPP3CC PPP3CC CSF1 CSF1 MAPK14 MAPK14 MAPK13 MAPK13 SPI1 SPI1 TGFB2 TGFB2 CTSK CTSK ACP5 ACP5 TEC TEC M3Y284_MUSPF M3Y284_MUSPF M3Y2C8_MUSPF M3Y2C8_MUSPF M3Y2L0_MUSPF M3Y2L0_MUSPF TYROBP TYROBP FOSB FOSB IRF9 IRF9 PIK3CD PIK3CD M3Y4E6_MUSPF M3Y4E6_MUSPF TGFBR1 TGFBR1 TYK2 TYK2 M3Y653_MUSPF M3Y653_MUSPF MAP2K7 MAP2K7 GAB2 GAB2 M3Y9K9_MUSPF M3Y9K9_MUSPF CYBA CYBA CALCR CALCR PTK6 PTK6 SRMS SRMS MAP3K14 MAP3K14 MAP3K7 MAP3K7 PIK3CB PIK3CB MAPK8 MAPK8 FOS FOS PLCG2 PLCG2 NFKB1 NFKB1 PPP3CA PPP3CA M3YDS7_MUSPF M3YDS7_MUSPF M3YDU1_MUSPF M3YDU1_MUSPF M3YDU6_MUSPF M3YDU6_MUSPF M3YDV7_MUSPF M3YDV7_MUSPF IL1A IL1A IKBKG IKBKG FYN FYN M3YG85_MUSPF M3YG85_MUSPF M3YGZ5_MUSPF M3YGZ5_MUSPF IL1B IL1B FHL2 FHL2 JUN JUN SOCS1 SOCS1 SOCS3 SOCS3 JUND JUND IFNB1 IFNB1 JUNB JUNB TAB2 TAB2 FOSL2 FOSL2 M3Z2N1_MUSPF M3Z2N1_MUSPF M3Z2M9_MUSPF M3Z2M9_MUSPF M3Z2D6_MUSPF M3Z2D6_MUSPF AKT2 AKT2 TGFB1 TGFB1 NFATC2 NFATC2 IFNG IFNG PIK3CA PIK3CA PPARG PPARG BLNK BLNK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BTKTyrosine-protein kinase. (659 aa)
MITFMelanocyte inducing transcription factor. (520 aa)
TNFRSF1ATNF receptor superfamily member 1A. (501 aa)
NFKB2Nuclear factor kappa B subunit 2. (900 aa)
NFATC1Nuclear factor of activated T cells 1. (701 aa)
TNFRSF11ATNF receptor superfamily member 11a. (603 aa)
RELCHRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1214 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
NCF1Neutrophil cytosolic factor 1. (391 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa)
M3YWA8_MUSPFUncharacterized protein. (726 aa)
LCKTyrosine-protein kinase. (509 aa)
NOXA1NADPH oxidase activator 1. (467 aa)
IFNGR1Interferon gamma receptor 1. (474 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (978 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
TREML1Triggering receptor expressed on myeloid cells like 1. (314 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
M3YNJ8_MUSPFUncharacterized protein. (461 aa)
LCP2Lymphocyte cytosolic protein 2. (536 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
M3YMK5_MUSPFProtein kinase domain-containing protein. (185 aa)
M3YMK1_MUSPFProtein kinase domain-containing protein. (105 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (399 aa)
NCF4Neutrophil cytosolic factor 4. (339 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
IL1R1Interleukin 1 receptor type 1. (573 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (445 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
NCF2Neutrophil cytosolic factor 2. (620 aa)
RELARELA proto-oncogene, NF-kB subunit. (511 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (271 aa)
TNFTumor necrosis factor alpha; Belongs to the tumor necrosis factor family. (233 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (569 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
MAPK9Mitogen-activated protein kinase. (398 aa)
SQSTM1Sequestosome 1. (371 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
TNFRSF11BTumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. (401 aa)
M3XQ69_MUSPFUncharacterized protein. (517 aa)
IFNAR1Interferon alpha and beta receptor subunit 1. (560 aa)
IFNGR2Interferon gamma receptor 2. (341 aa)
STAT2Signal transducer and activator of transcription. (848 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (321 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
M3XSU3_MUSPFUncharacterized protein. (482 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
M3XSV5_MUSPFIg-like domain-containing protein. (805 aa)
NOX1NADPH oxidase 1. (589 aa)
MAPK11Mitogen-activated protein kinase. (434 aa)
MAPK10Mitogen-activated protein kinase. (384 aa)
MAPK12Mitogen-activated protein kinase. (287 aa)
MAPK1Mitogen-activated protein kinase. (333 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (953 aa)
M3XWH1_MUSPFUncharacterized protein. (249 aa)
M3XWH7_MUSPFIg-like domain-containing protein. (315 aa)
PPP3CBSerine/threonine-protein phosphatase. (479 aa)
PPP3CCSerine/threonine-protein phosphatase. (525 aa)
CSF1Colony stimulating factor 1. (517 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
SPI1Spi-1 proto-oncogene. (257 aa)
TGFB2Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] (414 aa)
CTSKCathepsin K; Belongs to the peptidase C1 family. (339 aa)
ACP5Acid phosphatase 5, tartrate resistant. (335 aa)
TECTyrosine-protein kinase. (631 aa)
M3Y284_MUSPFUncharacterized protein. (410 aa)
M3Y2C8_MUSPFUncharacterized protein. (376 aa)
M3Y2L0_MUSPFFc of IgG, high affinity Ia, receptor. (352 aa)
TYROBPTYRO protein tyrosine kinase binding protein. (114 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (338 aa)
IRF9Interferon regulatory factor 9. (416 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
M3Y4E6_MUSPFUncharacterized protein. (160 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (480 aa)
TYK2Tyrosine-protein kinase. (1182 aa)
M3Y653_MUSPFProtein kinase domain-containing protein. (212 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (461 aa)
GAB2GRB2 associated binding protein 2. (639 aa)
M3Y9K9_MUSPFIntegrin beta; Belongs to the integrin beta chain family. (645 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (194 aa)
CALCRCalcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (504 aa)
PTK6Tyrosine-protein kinase. (444 aa)
SRMSTyrosine-protein kinase. (507 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (954 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
MAPK8Mitogen-activated protein kinase. (397 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (446 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1266 aa)
NFKB1Nuclear factor kappa B subunit 1. (971 aa)
PPP3CASerine/threonine-protein phosphatase. (461 aa)
M3YDS7_MUSPFUncharacterized protein. (507 aa)
M3YDU1_MUSPFIg-like domain-containing protein. (169 aa)
M3YDU6_MUSPFUncharacterized protein. (304 aa)
M3YDV7_MUSPFUncharacterized protein. (406 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (270 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (412 aa)
FYNTyrosine-protein kinase. (537 aa)
M3YG85_MUSPFIg-like domain-containing protein. (818 aa)
M3YGZ5_MUSPFIg-like domain-containing protein. (600 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (168 aa)
FHL2Four and a half LIM domains 2. (279 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
SOCS1Suppressor of cytokine signaling 1. (216 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
JUNDJunD proto-oncogene, AP-1 transcription factor subunit. (347 aa)
IFNB1Interferon beta. (186 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
FOSL2FOS like 2, AP-1 transcription factor subunit. (287 aa)
M3Z2N1_MUSPFUncharacterized protein. (385 aa)
M3Z2M9_MUSPFUncharacterized protein. (288 aa)
M3Z2D6_MUSPFIg-like domain-containing protein. (661 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
NFATC2Nuclear factor of activated T cells 2. (912 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). (166 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (475 aa)
BLNKB cell linker. (483 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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