(74 nodes) Antigen processing and presentation network (Mustela putorius)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HSPA8	Uncharacterized protein; Belongs to the heat shock protein 70 family. (643 aa)
	HSPA2	Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (635 aa)
	CREB1	cAMP responsive element binding protein 1. (341 aa)
	CANX	Calnexin. (484 aa)
	M3XPU6_MUSPF	Ig-like domain-containing protein; Belongs to the MHC class I family. (368 aa)
	CTSB	Cathepsin B; Belongs to the peptidase C1 family. (339 aa)
	RFXAP	Regulatory factor X associated protein. (281 aa)
	M3XS58_MUSPF	Ig-like domain-containing protein. (171 aa)
	M3XS65_MUSPF	ABC transporter domain-containing protein. (275 aa)
	TAP1	Transporter 1, ATP binding cassette subfamily B member. (686 aa)
	M3XS76_MUSPF	Ig-like domain-containing protein. (263 aa)
	HLA-DMA	Major histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family. (261 aa)
	HLA-DOA	Major histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa)
	HLA-DPA1	Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (242 aa)
	M3XSL7_MUSPF	Ig-like domain-containing protein; Belongs to the MHC class I family. (266 aa)
	M3XSM2_MUSPF	Uncharacterized protein. (164 aa)
	M3XSN5_MUSPF	Uncharacterized protein; Belongs to the MHC class I family. (304 aa)
	M3XSX9_MUSPF	Ig-like domain-containing protein. (366 aa)
	TAPBP	TAP binding protein. (462 aa)
	HSP90AA1	HATPase_c domain-containing protein. (679 aa)
	RFX5	Regulatory factor X5. (616 aa)
	CALR	Calreticulin. (417 aa)
	CTSS	Cathepsin S; Belongs to the peptidase C1 family. (342 aa)
	M3Y362_MUSPF	Uncharacterized protein; Belongs to the heat shock protein 70 family. (646 aa)
	M3Y3B0_MUSPF	Uncharacterized protein; Belongs to the peptidase C1 family. (333 aa)
	M3Y3D0_MUSPF	Uncharacterized protein; Belongs to the peptidase C1 family. (334 aa)
	PSME2	Proteasome activator subunit 2. (270 aa)
	PSME1	Proteasome activator subunit 1. (254 aa)
	KLRD1	Killer cell lectin like receptor D1. (179 aa)
	M3Y565_MUSPF	C-type lectin domain-containing protein. (235 aa)
	M3Y577_MUSPF	Uncharacterized protein. (163 aa)
	M3Y5B2_MUSPF	C-type lectin domain-containing protein. (219 aa)
	CTSV	Cathepsin V; Belongs to the peptidase C1 family. (335 aa)
	M3Y779_MUSPF	Ig-like domain-containing protein. (269 aa)
	M3Y7C9_MUSPF	Ig-like domain-containing protein. (266 aa)
	M3Y7D3_MUSPF	DUF1968 domain-containing protein. (157 aa)
	M3Y7K5_MUSPF	Ig-like domain-containing protein. (163 aa)
	TRAV18	T cell receptor alpha variable 18. (159 aa)
	LGMN	Legumain. (433 aa)
	M3Y8D0_MUSPF	Uncharacterized protein; Belongs to the heat shock protein 70 family. (617 aa)
	M3YAT2_MUSPF	Ig-like domain-containing protein. (186 aa)
	M3YAV2_MUSPF	Ig-like domain-containing protein. (141 aa)
	TRBV25-1	T cell receptor beta variable 25-1. (125 aa)
	M3YAY8_MUSPF	Ig-like domain-containing protein. (227 aa)
	M3YAZ8_MUSPF	Ig-like domain-containing protein. (158 aa)
	M3YB13_MUSPF	Ig-like domain-containing protein. (159 aa)
	CD8A	CD8a molecule. (242 aa)
	CD8B	Ig-like domain-containing protein. (209 aa)
	M3YDZ3_MUSPF	MHC_II_alpha domain-containing protein. (236 aa)
	M3YE13_MUSPF	Ig-like domain-containing protein. (233 aa)
	PSME3	Proteasome activator subunit 3. (254 aa)
	HSPA4	Heat shock protein family A (Hsp70) member 4. (795 aa)
	PDIA3	Protein disulfide-isomerase. (505 aa)
	M3YH07_MUSPF	Ig-like domain-containing protein. (265 aa)
	M3YHB9_MUSPF	Uncharacterized protein; Belongs to the heat shock protein 70 family. (642 aa)
	B2M	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (128 aa)
	TNF	Tumor necrosis factor alpha; Belongs to the tumor necrosis factor family. (233 aa)
	M3YJ13_MUSPF	MHC_I-like_Ag-recog domain-containing protein; Belongs to the MHC class I family. (88 aa)
	NFYB	Nuclear transcription factor Y subunit beta. (207 aa)
	M3YM35_MUSPF	Uncharacterized protein; Belongs to the heat shock protein 70 family. (567 aa)
	HSP90AB1	Heat shock protein 90 alpha family class B member 1. (724 aa)
	NFYA	Nuclear transcription factor Y subunit alpha. (347 aa)
	CD74	CD74 molecule. (279 aa)
	HSPA5	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family. (654 aa)
	M3YRC5_MUSPF	Ig-like domain-containing protein; Belongs to the MHC class I family. (357 aa)
	NFYC	Nuclear transcription factor Y subunit gamma. (335 aa)
	CIITA	Class II major histocompatibility complex transactivator. (1109 aa)
	LOC101678178	Ig-like domain-containing protein; Belongs to the MHC class II family. (196 aa)
	RFXANK	Regulatory factor X associated ankyrin containing protein. (260 aa)
	IFI30	IFI30 lysosomal thiol reductase. (252 aa)
	CD4	CD4. (462 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). (166 aa)
	KLRG1	Killer cell lectin like receptor G1. (190 aa)
	HSPA1L	Heat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family. (641 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B2M	CALR	ENSMPUP00000010744	ENSMPUP00000004315	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Calreticulin.	0.869
B2M	CD4	ENSMPUP00000010744	ENSMPUP00000016704	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	CD4.	0.448
B2M	CD74	ENSMPUP00000010744	ENSMPUP00000013683	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	CD74 molecule.	0.488
B2M	CD8A	ENSMPUP00000010744	ENSMPUP00000009228	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	CD8a molecule.	0.901
B2M	CD8B	ENSMPUP00000010744	ENSMPUP00000009237	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Ig-like domain-containing protein.	0.604
B2M	HLA-DMA	ENSMPUP00000010744	ENSMPUP00000001927	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Major histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family.	0.547
B2M	HLA-DOA	ENSMPUP00000010744	ENSMPUP00000001940	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Major histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family.	0.586
B2M	HLA-DPA1	ENSMPUP00000010744	ENSMPUP00000001943	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family.	0.572
B2M	KLRD1	ENSMPUP00000010744	ENSMPUP00000006423	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Killer cell lectin like receptor D1.	0.604
B2M	LOC101678178	ENSMPUP00000010744	ENSMPUP00000014877	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Ig-like domain-containing protein; Belongs to the MHC class II family.	0.595
B2M	M3XPU6_MUSPF	ENSMPUP00000010744	ENSMPUP00000001096	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Ig-like domain-containing protein; Belongs to the MHC class I family.	0.969
B2M	M3XS58_MUSPF	ENSMPUP00000010744	ENSMPUP00000001908	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Ig-like domain-containing protein.	0.602
B2M	M3XS76_MUSPF	ENSMPUP00000010744	ENSMPUP00000001926	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Ig-like domain-containing protein.	0.603
B2M	M3XSL7_MUSPF	ENSMPUP00000010744	ENSMPUP00000002067	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Ig-like domain-containing protein; Belongs to the MHC class I family.	0.953
B2M	M3XSN5_MUSPF	ENSMPUP00000010744	ENSMPUP00000002085	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Uncharacterized protein; Belongs to the MHC class I family.	0.953
B2M	M3XSX9_MUSPF	ENSMPUP00000010744	ENSMPUP00000002179	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Ig-like domain-containing protein.	0.471
B2M	M3Y779_MUSPF	ENSMPUP00000010744	ENSMPUP00000007186	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Ig-like domain-containing protein.	0.602
B2M	M3Y7D3_MUSPF	ENSMPUP00000010744	ENSMPUP00000007240	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	DUF1968 domain-containing protein.	0.849
B2M	M3YAZ8_MUSPF	ENSMPUP00000010744	ENSMPUP00000008505	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Ig-like domain-containing protein.	0.433
B2M	M3YDZ3_MUSPF	ENSMPUP00000010744	ENSMPUP00000009550	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	MHC_II_alpha domain-containing protein.	0.444