STRINGSTRING
CCL5 CCL5 NFKBIA NFKBIA MAP3K8 MAP3K8 CHUK CHUK PIK3CA PIK3CA TBK1 TBK1 CD40 CD40 AKT2 AKT2 M3YX17_MUSPF M3YX17_MUSPF M3Z217_MUSPF M3Z217_MUSPF LBP LBP BPI BPI TAB2 TAB2 TLR5 TLR5 TLR2 TLR2 IFNG-2 IFNG-2 M3Z715_MUSPF M3Z715_MUSPF M3Z722_MUSPF M3Z722_MUSPF M3Z729_MUSPF M3Z729_MUSPF LOC101678496 LOC101678496 LOC101678795 LOC101678795 IFNB1 IFNB1 M3Z7V7_MUSPF M3Z7V7_MUSPF LOC101684074 LOC101684074 M3Z7W2_MUSPF M3Z7W2_MUSPF LOC101684365 LOC101684365 LOC101684645 LOC101684645 M3Z7X0_MUSPF M3Z7X0_MUSPF LOC101674940 LOC101674940 LOC101676633 LOC101676633 TLR1 TLR1 TLR6 TLR6 JUN JUN M3YU63_MUSPF M3YU63_MUSPF M3YU47_MUSPF M3YU47_MUSPF PIK3R1 PIK3R1 MAP2K6 MAP2K6 IL6 IL6 TAB1 TAB1 IL12B IL12B M3YNJ8_MUSPF M3YNJ8_MUSPF IKBKB IKBKB MAPK3 MAPK3 STAT1 STAT1 BPIFC BPIFC IKBKE IKBKE TRAF6 TRAF6 M3YJV8_MUSPF M3YJV8_MUSPF RELA RELA TNF TNF TLR3 TLR3 IL1B IL1B LY96 LY96 IKBKG IKBKG NFKB1 NFKB1 CXCL8 CXCL8 FOS FOS M3YCL7_MUSPF M3YCL7_MUSPF MAPK8 MAPK8 PIK3CB PIK3CB MAP3K7 MAP3K7 IRAK1 IRAK1 IRF7 IRF7 CXCL9 CXCL9 CXCL10 CXCL10 CXCL11 CXCL11 CD14 CD14 CD80 CD80 MAP2K7 MAP2K7 TIRAP TIRAP TOLLIP TOLLIP PIK3CD PIK3CD IRF5 IRF5 TICAM1 TICAM1 CD86 CD86 M3Y027_MUSPF M3Y027_MUSPF FADD FADD CTSK CTSK MAPK13 MAPK13 MAPK14 MAPK14 MAP2K4 MAP2K4 MAPK1 MAPK1 IRF6 IRF6 IL12A IL12A MYD88 MYD88 TRAF3 TRAF3 TLR8 TLR8 TLR7 TLR7 IRF3 IRF3 MAPK12 MAPK12 MAPK10 MAPK10 MAPK11 MAPK11 SPP1 SPP1 AKT1 AKT1 TLR4 TLR4 IFNAR1 IFNAR1 M3XQ69_MUSPF M3XQ69_MUSPF TMED7 TMED7 MAPK9 MAPK9 RIPK1 RIPK1 MAP2K1 MAP2K1 IRAK4 IRAK4 CASP8 CASP8 MAP2K3 MAP2K3 M3YX15_MUSPF M3YX15_MUSPF AKT3 AKT3 M3YWA8_MUSPF M3YWA8_MUSPF TMED3 TMED3 M3YU74_MUSPF M3YU74_MUSPF M3YU65_MUSPF M3YU65_MUSPF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CCL5C-C motif chemokine. (91 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (467 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
TBK1TANK-binding kinase 1. (729 aa)
CD40CD40 molecule. (277 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
M3YX17_MUSPFUncharacterized protein. (158 aa)
M3Z217_MUSPFUncharacterized protein. (479 aa)
LBPLipopolysaccharide binding protein. (481 aa)
BPIBactericidal permeability increasing protein. (577 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
TLR5Toll like receptor 5; Belongs to the Toll-like receptor family. (858 aa)
TLR2Toll like receptor 2; Belongs to the Toll-like receptor family. (785 aa)
IFNG-2Uncharacterized protein. (187 aa)
M3Z715_MUSPFUncharacterized protein. (198 aa)
M3Z722_MUSPFUncharacterized protein. (187 aa)
M3Z729_MUSPFUncharacterized protein. (187 aa)
LOC101678496Uncharacterized protein. (187 aa)
LOC101678795Uncharacterized protein. (182 aa)
IFNB1Interferon beta. (186 aa)
M3Z7V7_MUSPFUncharacterized protein. (187 aa)
LOC101684074Uncharacterized protein. (187 aa)
M3Z7W2_MUSPFUncharacterized protein. (187 aa)
LOC101684365Uncharacterized protein. (187 aa)
LOC101684645Uncharacterized protein. (187 aa)
M3Z7X0_MUSPFUncharacterized protein. (187 aa)
LOC101674940Uncharacterized protein. (187 aa)
LOC101676633Uncharacterized protein. (187 aa)
TLR1Toll like receptor 1; Belongs to the Toll-like receptor family. (786 aa)
TLR6Toll like receptor 6; Belongs to the Toll-like receptor family. (793 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
M3YU63_MUSPFC-C motif chemokine. (107 aa)
M3YU47_MUSPFC-C motif chemokine. (93 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (210 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (331 aa)
M3YNJ8_MUSPFUncharacterized protein. (461 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (399 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
BPIFCBPI fold containing family C. (507 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (719 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
M3YJV8_MUSPFUncharacterized protein. (1327 aa)
RELARELA proto-oncogene, NF-kB subunit. (511 aa)
TNFTumor necrosis factor alpha; Belongs to the tumor necrosis factor family. (233 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (764 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (168 aa)
LY96Lymphocyte antigen 96. (160 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (412 aa)
NFKB1Nuclear factor kappa B subunit 1. (971 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (446 aa)
M3YCL7_MUSPFC-X-C motif chemokine. (94 aa)
MAPK8Mitogen-activated protein kinase. (397 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (696 aa)
IRF7Interferon regulatory factor 7. (473 aa)
CXCL9C-X-C motif chemokine. (155 aa)
CXCL10C-X-C motif chemokine. (98 aa)
CXCL11C-X-C motif chemokine. (132 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (371 aa)
CD80CD80 molecule. (302 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (461 aa)
TIRAPTIR domain containing adaptor protein. (227 aa)
TOLLIPToll interacting protein. (274 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
IRF5Interferon regulatory factor 5. (504 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (689 aa)
CD86CD86 molecule. (330 aa)
M3Y027_MUSPFProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (216 aa)
CTSKCathepsin K; Belongs to the peptidase C1 family. (339 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAP2K4Mitogen-activated protein kinase kinase 4. (281 aa)
MAPK1Mitogen-activated protein kinase. (333 aa)
IRF6Interferon regulatory factor 6. (462 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (569 aa)
TLR8Toll like receptor 8; Belongs to the Toll-like receptor family. (1087 aa)
TLR7Toll like receptor 7; Belongs to the Toll-like receptor family. (1083 aa)
IRF3Interferon regulatory factor 3. (421 aa)
MAPK12Mitogen-activated protein kinase. (287 aa)
MAPK10Mitogen-activated protein kinase. (384 aa)
MAPK11Mitogen-activated protein kinase. (434 aa)
SPP1Secreted phosphoprotein 1. (272 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
IFNAR1Interferon alpha and beta receptor subunit 1. (560 aa)
M3XQ69_MUSPFUncharacterized protein. (517 aa)
TMED7GOLD domain-containing protein. (224 aa)
MAPK9Mitogen-activated protein kinase. (398 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (646 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
IRAK4Interleukin-1 receptor-associated kinase 4. (460 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (484 aa)
MAP2K3Mitogen-activated protein kinase kinase 3. (396 aa)
M3YX15_MUSPFUncharacterized protein. (161 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa)
M3YWA8_MUSPFUncharacterized protein. (726 aa)
TMED3Transmembrane p24 trafficking protein 3. (166 aa)
M3YU74_MUSPFC-C motif chemokine. (92 aa)
M3YU65_MUSPFC-C motif chemokine. (93 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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