(79 nodes) RIG-I-like receptor signaling pathway network (Mustela putorius)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CYLD	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (953 aa)
	IL12A	Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
	TRAF3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (569 aa)
	IRF3	Interferon regulatory factor 3. (421 aa)
	MAPK12	Mitogen-activated protein kinase. (287 aa)
	MAPK10	Mitogen-activated protein kinase. (384 aa)
	ATG12	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
	MAPK11	Mitogen-activated protein kinase. (434 aa)
	MAPK9	Mitogen-activated protein kinase. (398 aa)
	IFIH1	Interferon induced with helicase C domain 1. (1027 aa)
	TANK	TRAF family member associated NFKB activator. (446 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (646 aa)
	CASP8	Caspase 8; Belongs to the peptidase C14A family. (484 aa)
	CASP10	Caspase 10; Belongs to the peptidase C14A family. (545 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
	NFKBIA	NFKB inhibitor alpha. (314 aa)
	M3YX17_MUSPF	Uncharacterized protein. (158 aa)
	M3YX15_MUSPF	Uncharacterized protein. (161 aa)
	IFNE	Interferon epsilon. (181 aa)
	TRIM25	Tripartite motif containing 25. (653 aa)
	COIL	Coilin. (578 aa)
	TBKBP1	TBK1 binding protein 1. (375 aa)
	RNF135	Ring finger protein 135. (419 aa)
	PIN1	Peptidyl-prolyl cis-trans isomerase. (162 aa)
	TKFC	Triokinase and FMN cyclase. (578 aa)
	M3YRF3_MUSPF	Uncharacterized protein. (654 aa)
	ISG15	ISG15 ubiquitin like modifier. (184 aa)
	TRIM47	Tripartite motif containing 47. (400 aa)
	LOC101676633	Uncharacterized protein. (187 aa)
	LOC101674940	Uncharacterized protein. (187 aa)
	M3Z7X0_MUSPF	Uncharacterized protein. (187 aa)
	LOC101684645	Uncharacterized protein. (187 aa)
	LOC101684365	Uncharacterized protein. (187 aa)
	M3Z7W2_MUSPF	Uncharacterized protein. (187 aa)
	LOC101684074	Uncharacterized protein. (187 aa)
	M3Z7V7_MUSPF	Uncharacterized protein. (187 aa)
	IFNK	Interferon kappa. (202 aa)
	IFNB1	Interferon beta. (186 aa)
	LOC101678795	Uncharacterized protein. (182 aa)
	AZI2	5-azacytidine induced 2. (429 aa)
	IKBKE	Inhibitor of nuclear factor kappa B kinase subunit epsilon. (719 aa)
	DDX3X	DEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (662 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
	IL12B	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (331 aa)
	OTUD5	OTU deubiquitinase 5. (566 aa)
	TRIM65	Tripartite motif containing 65. (517 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
	LOC101678496	Uncharacterized protein. (187 aa)
	M3Z729_MUSPF	Uncharacterized protein. (187 aa)
	M3Z722_MUSPF	Uncharacterized protein. (187 aa)
	M3Z715_MUSPF	Uncharacterized protein. (198 aa)
	IFNG-2	Uncharacterized protein. (187 aa)
	NFKBIB	NFKB inhibitor beta. (354 aa)
	TBK1	TANK-binding kinase 1. (729 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (511 aa)
	TNF	Tumor necrosis factor alpha; Belongs to the tumor necrosis factor family. (233 aa)
	TRAF2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (569 aa)
	DHX58	DExH-box helicase 58. (679 aa)
	FGFR1OP2	FGFR1 oncogene partner 2. (253 aa)
	IKBKG	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (412 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (971 aa)
	CXCL8	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
	M3YCL7_MUSPF	C-X-C motif chemokine. (94 aa)
	MAPK8	Mitogen-activated protein kinase. (397 aa)
	STING1	Transmembrane protein 173. (378 aa)
	MAP3K7	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
	IRF7	Interferon regulatory factor 7. (473 aa)
	MAVS	Mitochondrial antiviral signaling protein. (524 aa)
	CXCL10	C-X-C motif chemokine. (98 aa)
	MAP3K1	Mitogen-activated protein kinase kinase kinase 1. (1343 aa)
	RNF125	Ring finger protein 125. (232 aa)
	SIKE1	Suppressor of IKBKE 1. (207 aa)
	TRADD	TNFRSF1A associated via death domain. (314 aa)
	NLRX1	NLR family member X1. (975 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (216 aa)
	DDX58	DExD/H-box helicase 58. (937 aa)
	MAPK13	Mitogen-activated protein kinase. (366 aa)
	MAPK14	Mitogen-activated protein kinase. (360 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATG12	ATG5	ENSMPUP00000000771	ENSMPUP00000009457	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.999
ATG12	DDX58	ENSMPUP00000000771	ENSMPUP00000004286	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	DExD/H-box helicase 58.	0.963
ATG12	DHX58	ENSMPUP00000000771	ENSMPUP00000010490	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	DExH-box helicase 58.	0.485
ATG12	FADD	ENSMPUP00000000771	ENSMPUP00000004665	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.480
ATG12	IFIH1	ENSMPUP00000000771	ENSMPUP00000000558	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Interferon induced with helicase C domain 1.	0.640
ATG12	MAVS	ENSMPUP00000000771	ENSMPUP00000008630	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Mitochondrial antiviral signaling protein.	0.968
ATG12	NLRX1	ENSMPUP00000000771	ENSMPUP00000005268	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	NLR family member X1.	0.536
ATG5	ATG12	ENSMPUP00000009457	ENSMPUP00000000771	Autophagy protein 5; Involved in autophagic vesicle formation.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.999
ATG5	CASP10	ENSMPUP00000009457	ENSMPUP00000000228	Autophagy protein 5; Involved in autophagic vesicle formation.	Caspase 10; Belongs to the peptidase C14A family.	0.468
ATG5	CASP8	ENSMPUP00000009457	ENSMPUP00000000237	Autophagy protein 5; Involved in autophagic vesicle formation.	Caspase 8; Belongs to the peptidase C14A family.	0.613
ATG5	DDX58	ENSMPUP00000009457	ENSMPUP00000004286	Autophagy protein 5; Involved in autophagic vesicle formation.	DExD/H-box helicase 58.	0.963
ATG5	DHX58	ENSMPUP00000009457	ENSMPUP00000010490	Autophagy protein 5; Involved in autophagic vesicle formation.	DExH-box helicase 58.	0.482
ATG5	FADD	ENSMPUP00000009457	ENSMPUP00000004665	Autophagy protein 5; Involved in autophagic vesicle formation.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.892
ATG5	IFIH1	ENSMPUP00000009457	ENSMPUP00000000558	Autophagy protein 5; Involved in autophagic vesicle formation.	Interferon induced with helicase C domain 1.	0.630
ATG5	MAVS	ENSMPUP00000009457	ENSMPUP00000008630	Autophagy protein 5; Involved in autophagic vesicle formation.	Mitochondrial antiviral signaling protein.	0.964
ATG5	NLRX1	ENSMPUP00000009457	ENSMPUP00000005268	Autophagy protein 5; Involved in autophagic vesicle formation.	NLR family member X1.	0.556
ATG5	RIPK1	ENSMPUP00000009457	ENSMPUP00000000449	Autophagy protein 5; Involved in autophagic vesicle formation.	Receptor interacting serine/threonine kinase 1.	0.404
ATG5	TNF	ENSMPUP00000009457	ENSMPUP00000011297	Autophagy protein 5; Involved in autophagic vesicle formation.	Tumor necrosis factor alpha; Belongs to the tumor necrosis factor family.	0.418
AZI2	CHUK	ENSMPUP00000011878	ENSMPUP00000016874	5-azacytidine induced 2.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.560
AZI2	IKBKB	ENSMPUP00000011878	ENSMPUP00000012607	5-azacytidine induced 2.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.560