STRINGSTRING
CGAS CGAS DDX58 DDX58 POLR3A POLR3A IL18 IL18 POLR3D POLR3D PIWIL2 PIWIL2 POLR2H POLR2H IRF3 IRF3 M3XQ91_MUSPF M3XQ91_MUSPF POLR3GL POLR3GL POLR3C POLR3C RIPK1 RIPK1 POLR3E POLR3E IL33 IL33 POLR3H POLR3H NFKBIA NFKBIA M3YX17_MUSPF M3YX17_MUSPF M3YX15_MUSPF M3YX15_MUSPF M3YU74_MUSPF M3YU74_MUSPF CCL5 CCL5 IL6 IL6 POLR2F POLR2F POLR1C POLR1C IKBKB IKBKB POLR3B POLR3B IKBKE IKBKE RELA RELA PYCARD PYCARD IL1B IL1B IKBKG IKBKG NFKB1 NFKB1 STING1 STING1 POLR2E POLR2E IRF7 IRF7 MAVS MAVS LOC101684645 LOC101684645 M3Z7X0_MUSPF M3Z7X0_MUSPF LOC101674940 LOC101674940 LOC101676633 LOC101676633 LOC101684365 LOC101684365 M3Z7W2_MUSPF M3Z7W2_MUSPF LOC101684074 LOC101684074 M3Z7V7_MUSPF M3Z7V7_MUSPF TREX1 TREX1 TREX2 TREX2 IFNB1 IFNB1 LOC101678795 LOC101678795 LOC101678496 LOC101678496 M3Z729_MUSPF M3Z729_MUSPF M3Z722_MUSPF M3Z722_MUSPF M3Z715_MUSPF M3Z715_MUSPF IFNG-2 IFNG-2 NFKBIB NFKBIB TBK1 TBK1 CHUK CHUK CXCL10 CXCL10 M3Y940_MUSPF M3Y940_MUSPF M3Y8H9_MUSPF M3Y8H9_MUSPF ADAR ADAR M3Y5L5_MUSPF M3Y5L5_MUSPF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CGASCyclic GMP-AMP synthase. (526 aa)
DDX58DExD/H-box helicase 58. (937 aa)
POLR3ADNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1402 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
POLR3DRNA polymerase III subunit D. (398 aa)
PIWIL2Piwi like RNA-mediated gene silencing 2; Belongs to the argonaute family. (970 aa)
POLR2HDNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (150 aa)
IRF3Interferon regulatory factor 3. (421 aa)
M3XQ91_MUSPFDNA-directed RNA polymerase III subunit RPC6; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs; Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family. (322 aa)
POLR3GLDNA-directed RNA polymerase III subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. (218 aa)
POLR3CRNA polymerase III subunit C3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (534 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (646 aa)
POLR3ERNA polymerase III subunit E. (714 aa)
IL33Interleukin 33. (268 aa)
POLR3HRNA polymerase III subunit H. (204 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
M3YX17_MUSPFUncharacterized protein. (158 aa)
M3YX15_MUSPFUncharacterized protein. (161 aa)
M3YU74_MUSPFC-C motif chemokine. (92 aa)
CCL5C-C motif chemokine. (91 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (210 aa)
POLR2FRNA polymerase II subunit F. (127 aa)
POLR1CRNA polymerase I and III subunit C. (380 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
POLR3BDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1133 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (719 aa)
RELARELA proto-oncogene, NF-kB subunit. (511 aa)
PYCARDPYD and CARD domain containing. (193 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (168 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (412 aa)
NFKB1Nuclear factor kappa B subunit 1. (971 aa)
STING1Transmembrane protein 173. (378 aa)
POLR2ERNA polymerase II subunit E. (210 aa)
IRF7Interferon regulatory factor 7. (473 aa)
MAVSMitochondrial antiviral signaling protein. (524 aa)
LOC101684645Uncharacterized protein. (187 aa)
M3Z7X0_MUSPFUncharacterized protein. (187 aa)
LOC101674940Uncharacterized protein. (187 aa)
LOC101676633Uncharacterized protein. (187 aa)
LOC101684365Uncharacterized protein. (187 aa)
M3Z7W2_MUSPFUncharacterized protein. (187 aa)
LOC101684074Uncharacterized protein. (187 aa)
M3Z7V7_MUSPFUncharacterized protein. (187 aa)
TREX1Three prime repair exonuclease 1. (313 aa)
TREX2Three prime repair exonuclease 2-like protein. (236 aa)
IFNB1Interferon beta. (186 aa)
LOC101678795Uncharacterized protein. (182 aa)
LOC101678496Uncharacterized protein. (187 aa)
M3Z729_MUSPFUncharacterized protein. (187 aa)
M3Z722_MUSPFUncharacterized protein. (187 aa)
M3Z715_MUSPFUncharacterized protein. (198 aa)
IFNG-2Uncharacterized protein. (187 aa)
NFKBIBNFKB inhibitor beta. (354 aa)
TBK1TANK-binding kinase 1. (729 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
CXCL10C-X-C motif chemokine. (98 aa)
M3Y940_MUSPFUncharacterized protein. (219 aa)
M3Y8H9_MUSPFUncharacterized protein. (93 aa)
ADARAdenosine deaminase RNA specific. (1166 aa)
M3Y5L5_MUSPFUncharacterized protein. (444 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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