(122 nodes) Natural killer cell mediated cytotoxicity network (Mustela putorius)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FCER1G	Fc fragment of IgE receptor Ig. (86 aa)
	LOC101676633	Uncharacterized protein. (187 aa)
	LOC101674940	Uncharacterized protein. (187 aa)
	M3Z7X0_MUSPF	Uncharacterized protein. (187 aa)
	LOC101684645	Uncharacterized protein. (187 aa)
	LOC101684365	Uncharacterized protein. (187 aa)
	M3Z7W2_MUSPF	Uncharacterized protein. (187 aa)
	LOC101684074	Uncharacterized protein. (187 aa)
	M3Z7V7_MUSPF	Uncharacterized protein. (187 aa)
	IFNB1	Interferon beta. (186 aa)
	LOC101678795	Uncharacterized protein. (182 aa)
	LOC101678496	Uncharacterized protein. (187 aa)
	M3Z729_MUSPF	Uncharacterized protein. (187 aa)
	M3Z722_MUSPF	Uncharacterized protein. (187 aa)
	IFNG-2	Uncharacterized protein. (187 aa)
	M3Z308_MUSPF	MHC_I-like_Ag-recog domain-containing protein. (229 aa)
	M3Z307_MUSPF	MHC_I_2 domain-containing protein. (241 aa)
	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
	NFATC2	Nuclear factor of activated T cells 2. (912 aa)
	KLRG1	Killer cell lectin like receptor G1. (190 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). (166 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (644 aa)
	TNFSF10	TNF superfamily member 10; Belongs to the tumor necrosis factor family. (320 aa)
	PTPN6	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (595 aa)
	NFATC1	Nuclear factor of activated T cells 1. (701 aa)
	RAC1	Rac family small GTPase 1. (167 aa)
	M3YX17_MUSPF	Uncharacterized protein. (158 aa)
	M3YX15_MUSPF	Uncharacterized protein. (161 aa)
	PAK1	Non-specific serine/threonine protein kinase. (544 aa)
	M3YWA8_MUSPF	Uncharacterized protein. (726 aa)
	CD247	CD247 molecule. (185 aa)
	FASLG	Fas ligand; Belongs to the tumor necrosis factor family. (275 aa)
	LCK	Tyrosine-protein kinase. (509 aa)
	IFNGR1	Interferon gamma receptor 1. (474 aa)
	ICAM2	Intercellular adhesion molecule 2. (290 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (688 aa)
	CD244	CD244 molecule. (358 aa)
	CD48	Ig-like domain-containing protein. (242 aa)
	M3YR72_MUSPF	Uncharacterized protein. (542 aa)
	GRB2	Growth factor receptor bound protein 2. (217 aa)
	M3YQA4_MUSPF	Ig-like domain-containing protein. (252 aa)
	ARAF	V-raf murine sarcoma 3611 viral oncoprotein-like protein. (606 aa)
	M3YNJ8_MUSPF	Uncharacterized protein. (461 aa)
	LCP2	Lymphocyte cytosolic protein 2. (536 aa)
	LAT	Linker for activation of T cells. (260 aa)
	RAC2	Rac family small GTPase 2. (192 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (399 aa)
	SHC4	SHC adaptor protein 4. (624 aa)
	ITGAL	Integrin subunit alpha L; Belongs to the integrin alpha chain family. (1166 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (577 aa)
	VAV2	Vav guanine nucleotide exchange factor 2. (834 aa)
	CSF2	Colony stimulating factor 2. (148 aa)
	TNF	Tumor necrosis factor alpha; Belongs to the tumor necrosis factor family. (233 aa)
	NCR3	Natural cytotoxicity triggering receptor 3. (201 aa)
	ZAP70	Tyrosine-protein kinase. (616 aa)
	RAC3	Rac family small GTPase 3. (160 aa)
	CASP3	Caspase 3; Belongs to the peptidase C14A family. (277 aa)
	SH3BP2	SH3 domain binding protein 2. (592 aa)
	M3YH29_MUSPF	Uncharacterized protein. (180 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1276 aa)
	M3YG48_MUSPF	MHC_I-like_Ag-recog domain-containing protein. (249 aa)
	M3YG45_MUSPF	Uncharacterized protein. (124 aa)
	LOC101685787	MHC_I-like_Ag-recog domain-containing protein. (261 aa)
	M3YG36_MUSPF	Uncharacterized protein. (251 aa)
	M3YG20_MUSPF	MHC_I_2 domain-containing protein. (256 aa)
	M3YG14_MUSPF	MHC_I-like_Ag-recog domain-containing protein. (245 aa)
	KRAS	KRAS proto-oncogene, GTPase. (208 aa)
	ITGB2	Integrin beta. (782 aa)
	FYN	Tyrosine-protein kinase. (537 aa)
	PRKCG	Non-specific serine/threonine protein kinase. (569 aa)
	M3YF44_MUSPF	Ig-like domain-containing protein. (122 aa)
	SHC2	Uncharacterized protein. (539 aa)
	PPP3CA	Serine/threonine-protein phosphatase. (461 aa)
	PLCG2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1266 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
	SHC3	SHC adaptor protein 3. (425 aa)
	SRMS	Tyrosine-protein kinase. (507 aa)
	PTK6	Tyrosine-protein kinase. (444 aa)
	M3Y9A1_MUSPF	Uncharacterized protein. (364 aa)
	VAV1	Vav guanine nucleotide exchange factor 1. (845 aa)
	M3Y653_MUSPF	Protein kinase domain-containing protein. (212 aa)
	M3Y650_MUSPF	Ig-like domain-containing protein. (142 aa)
	M3Y645_MUSPF	Ig-like domain-containing protein. (167 aa)
	ICAM1	Intercellular adhesion molecule 1. (589 aa)
	M3Y5B2_MUSPF	C-type lectin domain-containing protein. (219 aa)
	M3Y577_MUSPF	Uncharacterized protein. (163 aa)
	M3Y565_MUSPF	C-type lectin domain-containing protein. (235 aa)
	FAS	Fas cell surface death receptor. (311 aa)
	KLRD1	Killer cell lectin like receptor D1. (179 aa)
	M3Y4E6_MUSPF	Uncharacterized protein. (160 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
	SHC1	SHC adaptor protein 1. (586 aa)
	M3Y3E0_MUSPF	Ig-like domain-containing protein. (121 aa)
	TYROBP	TYRO protein tyrosine kinase binding protein. (114 aa)
	CSDE1	Cold shock domain containing E1. (784 aa)
	M3Y2Z6_MUSPF	Uncharacterized protein. (189 aa)
	GZMB	Granzyme B; Belongs to the peptidase S1 family. (258 aa)
	M3Y0Z9_MUSPF	Uncharacterized protein. (127 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (1281 aa)
	M3Y027_MUSPF	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
	PRF1	Perforin 1. (602 aa)
	PPP3CC	Serine/threonine-protein phosphatase. (525 aa)
	SH2D1B	SH2 domain-containing protein. (143 aa)
	PPP3CB	Serine/threonine-protein phosphatase. (479 aa)
	M3XWH1_MUSPF	Uncharacterized protein. (249 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (715 aa)
	MAPK1	Mitogen-activated protein kinase. (333 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
	NCR1	Natural cytotoxicity triggering receptor 1. (281 aa)
	M3XSX9_MUSPF	Ig-like domain-containing protein. (366 aa)
	M3XRT3_MUSPF	Ig-like domain-containing protein. (118 aa)
	M3XRS9_MUSPF	Ig-like domain-containing protein. (117 aa)
	M3XRJ3_MUSPF	Uncharacterized protein. (182 aa)
	SH2D1A	SH2 domain-containing protein 1A; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. (124 aa)
	IFNGR2	Interferon gamma receptor 2. (341 aa)
	IFNAR1	Interferon alpha and beta receptor subunit 1. (560 aa)
	M3XQ69_MUSPF	Uncharacterized protein. (517 aa)
	PTK2B	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
	VAV3	Vav guanine nucleotide exchange factor 3. (847 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARAF	BRAF	ENSMPUP00000013247	ENSMPUP00000003381	V-raf murine sarcoma 3611 viral oncoprotein-like protein.	B-Raf proto-oncogene, serine/threonine kinase.	0.951
ARAF	CSDE1	ENSMPUP00000013247	ENSMPUP00000005706	V-raf murine sarcoma 3611 viral oncoprotein-like protein.	Cold shock domain containing E1.	0.692
ARAF	FYN	ENSMPUP00000013247	ENSMPUP00000010147	V-raf murine sarcoma 3611 viral oncoprotein-like protein.	Tyrosine-protein kinase.	0.448
ARAF	KRAS	ENSMPUP00000013247	ENSMPUP00000010217	V-raf murine sarcoma 3611 viral oncoprotein-like protein.	KRAS proto-oncogene, GTPase.	0.981
ARAF	LCK	ENSMPUP00000013247	ENSMPUP00000015151	V-raf murine sarcoma 3611 viral oncoprotein-like protein.	Tyrosine-protein kinase.	0.503
ARAF	M3Y027_MUSPF	ENSMPUP00000013247	ENSMPUP00000004678	V-raf murine sarcoma 3611 viral oncoprotein-like protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.930
ARAF	M3Y2Z6_MUSPF	ENSMPUP00000013247	ENSMPUP00000005697	V-raf murine sarcoma 3611 viral oncoprotein-like protein.	Uncharacterized protein.	0.942
ARAF	M3YH29_MUSPF	ENSMPUP00000013247	ENSMPUP00000010636	V-raf murine sarcoma 3611 viral oncoprotein-like protein.	Uncharacterized protein.	0.942
ARAF	M3YNJ8_MUSPF	ENSMPUP00000013247	ENSMPUP00000012905	V-raf murine sarcoma 3611 viral oncoprotein-like protein.	Uncharacterized protein.	0.482
ARAF	M3YWA8_MUSPF	ENSMPUP00000013247	ENSMPUP00000015618	V-raf murine sarcoma 3611 viral oncoprotein-like protein.	Uncharacterized protein.	0.527
ARAF	MAP2K1	ENSMPUP00000013247	ENSMPUP00000000360	V-raf murine sarcoma 3611 viral oncoprotein-like protein.	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily.	0.930
ARAF	MAPK1	ENSMPUP00000013247	ENSMPUP00000003112	V-raf murine sarcoma 3611 viral oncoprotein-like protein.	Mitogen-activated protein kinase.	0.558
ARAF	MAPK3	ENSMPUP00000013247	ENSMPUP00000012543	V-raf murine sarcoma 3611 viral oncoprotein-like protein.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.558
ARAF	PIK3CA	ENSMPUP00000013247	ENSMPUP00000017099	V-raf murine sarcoma 3611 viral oncoprotein-like protein.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.584
ARAF	PIK3CB	ENSMPUP00000013247	ENSMPUP00000009047	V-raf murine sarcoma 3611 viral oncoprotein-like protein.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.696
ARAF	PIK3CD	ENSMPUP00000013247	ENSMPUP00000006192	V-raf murine sarcoma 3611 viral oncoprotein-like protein.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.534
ARAF	PIK3R1	ENSMPUP00000013247	ENSMPUP00000014610	V-raf murine sarcoma 3611 viral oncoprotein-like protein.	Phosphoinositide-3-kinase regulatory subunit 1.	0.536
ARAF	PRKCA	ENSMPUP00000013247	ENSMPUP00000014555	V-raf murine sarcoma 3611 viral oncoprotein-like protein.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.931
ARAF	PRKCB	ENSMPUP00000013247	ENSMPUP00000012100	V-raf murine sarcoma 3611 viral oncoprotein-like protein.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.931
ARAF	PRKCG	ENSMPUP00000013247	ENSMPUP00000010076	V-raf murine sarcoma 3611 viral oncoprotein-like protein.	Non-specific serine/threonine protein kinase.	0.931