STRINGSTRING
VCAM1 VCAM1 JUN JUN SOCS3 SOCS3 IFNB1 IFNB1 CEBPB CEBPB JUNB JUNB TAB2 TAB2 ITCH ITCH AKT2 AKT2 MMP9 MMP9 PIK3CA PIK3CA CHUK CHUK TNFRSF1A TNFRSF1A MAP3K8 MAP3K8 TNFRSF1B TNFRSF1B NFKBIA NFKBIA IL15 IL15 TRAF5 TRAF5 AKT3 AKT3 M3YWA8_MUSPF M3YWA8_MUSPF SELE SELE CCL5 CCL5 TNFAIP3 TNFAIP3 CCL2 CCL2 MAP3K5 MAP3K5 PIK3R1 PIK3R1 MAP2K6 MAP2K6 ATF2 ATF2 IL6 IL6 M3YPM9_MUSPF M3YPM9_MUSPF TAB1 TAB1 LIF LIF M3YNJ8_MUSPF M3YNJ8_MUSPF RPS6KA4 RPS6KA4 IKBKB IKBKB MAPK3 MAPK3 IL18R1 IL18R1 VEGFC VEGFC RELA RELA CSF2 CSF2 LTA LTA TNF TNF CASP3 CASP3 TRAF2 TRAF2 PTGS2 PTGS2 IL1B IL1B IRF1 IRF1 ATF6B ATF6B RFWD3 RFWD3 M3YEN4_MUSPF M3YEN4_MUSPF BAG4 BAG4 IKBKG IKBKG NFKB1 NFKB1 FOS FOS MAPK8 MAPK8 PIK3CB PIK3CB MAP3K7 MAP3K7 CXCL10 CXCL10 MAP3K14 MAP3K14 RPS6KA5 RPS6KA5 MAP2K7 MAP2K7 CREB3L4 CREB3L4 TRAF1 TRAF1 DAB2IP DAB2IP MMP14 MMP14 BIRC3 BIRC3 BIRC2 BIRC2 M3Y672_MUSPF M3Y672_MUSPF LOC101688701 LOC101688701 MMP12 MMP12 ICAM1 ICAM1 IRGC IRGC JAG1 JAG1 FAS FAS CEACAM16 CEACAM16 BCL3 BCL3 PIK3CD PIK3CD CREB3L1 CREB3L1 CREB3 CREB3 TRADD TRADD CREB5 CREB5 CREB3L3 CREB3L3 FADD FADD CX3CL1 CX3CL1 MAPK13 MAPK13 CREB3L2 CREB3L2 MAPK14 MAPK14 CSF1 CSF1 MAP2K4 MAP2K4 NOD2 NOD2 MAPK1 MAPK1 VEGFD VEGFD PGAM5 PGAM5 TRAF3 TRAF3 TAB3 TAB3 MAPK12 MAPK12 MAPK10 MAPK10 MAPK11 MAPK11 AKT1 AKT1 CASP7 CASP7 CCL20 CCL20 EDN1 EDN1 MAPK9 MAPK9 M3XNB9_MUSPF M3XNB9_MUSPF CREB1 CREB1 RIPK1 RIPK1 MAP2K1 MAP2K1 CASP8 CASP8 CASP10 CASP10 CFLAR CFLAR DNM1L DNM1L MAP2K3 MAP2K3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VCAM1Vascular cell adhesion molecule 1. (739 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
IFNB1Interferon beta. (186 aa)
CEBPBCCAAT/enhancer-binding protein. (346 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
ITCHE3 ubiquitin-protein ligase. (880 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
MMP9Matrix metallopeptidase 9. (704 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
TNFRSF1ATNF receptor superfamily member 1A. (501 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (467 aa)
TNFRSF1BTNF receptor superfamily member 1B. (509 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa)
M3YWA8_MUSPFUncharacterized protein. (726 aa)
SELESelectin E. (609 aa)
CCL5C-C motif chemokine. (91 aa)
TNFAIP3TNF alpha induced protein 3. (790 aa)
CCL2C-C motif chemokine. (101 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1398 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (210 aa)
M3YPM9_MUSPFBZIP domain-containing protein. (351 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
M3YNJ8_MUSPFUncharacterized protein. (461 aa)
RPS6KA4Ribosomal protein S6 kinase. (772 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (399 aa)
IL18R1Interleukin 18 receptor 1. (539 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (370 aa)
RELARELA proto-oncogene, NF-kB subunit. (511 aa)
CSF2Colony stimulating factor 2. (148 aa)
LTALymphotoxin alpha; Belongs to the tumor necrosis factor family. (204 aa)
TNFTumor necrosis factor alpha; Belongs to the tumor necrosis factor family. (233 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (569 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (168 aa)
IRF1Interferon regulatory factor. (322 aa)
ATF6BActivating transcription factor 6 beta. (707 aa)
RFWD3Ring finger and WD repeat domain 3. (772 aa)
M3YEN4_MUSPFBZIP domain-containing protein. (358 aa)
BAG4BCL2 associated athanogene 4. (457 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (412 aa)
NFKB1Nuclear factor kappa B subunit 1. (971 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (446 aa)
MAPK8Mitogen-activated protein kinase. (397 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
CXCL10C-X-C motif chemokine. (98 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (954 aa)
RPS6KA5Ribosomal protein S6 kinase. (821 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (461 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (386 aa)
TRAF1TNF receptor-associated factor. (415 aa)
DAB2IPDAB2 interacting protein. (1112 aa)
MMP14Matrix metallopeptidase 14. (582 aa)
BIRC3Baculoviral IAP repeat containing 3. (604 aa)
BIRC2Baculoviral IAP repeat containing 2. (570 aa)
M3Y672_MUSPFUncharacterized protein. (100 aa)
LOC101688701ZnMc domain-containing protein. (476 aa)
MMP12Matrix metallopeptidase 12. (493 aa)
ICAM1Intercellular adhesion molecule 1. (589 aa)
IRGCImmunity related GTPase cinema. (736 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
FASFas cell surface death receptor. (311 aa)
CEACAM16Carcinoembryonic antigen related cell adhesion molecule 16. (424 aa)
BCL3BCL3 transcription coactivator. (456 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (520 aa)
CREB3cAMP responsive element binding protein 3. (353 aa)
TRADDTNFRSF1A associated via death domain. (314 aa)
CREB5cAMP responsive element binding protein 5. (275 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (473 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (216 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (461 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
CSF1Colony stimulating factor 1. (517 aa)
MAP2K4Mitogen-activated protein kinase kinase 4. (281 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1013 aa)
MAPK1Mitogen-activated protein kinase. (333 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
PGAM5PGAM family member 5, mitochondrial serine/threonine protein phosphatase. (226 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (569 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (715 aa)
MAPK12Mitogen-activated protein kinase. (287 aa)
MAPK10Mitogen-activated protein kinase. (384 aa)
MAPK11Mitogen-activated protein kinase. (434 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CASP7Caspase 7; Belongs to the peptidase C14A family. (301 aa)
CCL20C-C motif chemokine. (97 aa)
EDN1Endothelin 1. (202 aa)
MAPK9Mitogen-activated protein kinase. (398 aa)
M3XNB9_MUSPFUncharacterized protein. (795 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (646 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (484 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (545 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (482 aa)
DNM1LDynamin 1 like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (749 aa)
MAP2K3Mitogen-activated protein kinase kinase 3. (396 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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