STRINGSTRING
VAV1 VAV1 AFDN AFDN PIK3CD PIK3CD ESAM ESAM NOXA1 NOXA1 PECAM1 PECAM1 PIK3R1 PIK3R1 PRKCA PRKCA OCLN OCLN F11R F11R M3YR72_MUSPF M3YR72_MUSPF CLDN19 CLDN19 RHOA RHOA ROCK2 ROCK2 ITK ITK GNAI2 GNAI2 M3YNJ8_MUSPF M3YNJ8_MUSPF RAC2 RAC2 NCF4 NCF4 CYBB CYBB XK XK MYLPF MYLPF ITGAL ITGAL PRKCB PRKCB VAV2 VAV2 RASSF5 RASSF5 VCAM1 VCAM1 M3YKK2_MUSPF M3YKK2_MUSPF M3YKJ5_MUSPF M3YKJ5_MUSPF CLDN10 CLDN10 NCF2 NCF2 SIPA1 SIPA1 ACTG1 ACTG1 CD99L2 CD99L2 VAV3 VAV3 CTNND1 CTNND1 LPXN LPXN M3XMV4_MUSPF M3XMV4_MUSPF RAPGEF4 RAPGEF4 PTK2B PTK2B JAM2 JAM2 GABPA GABPA ARHGAP5 ARHGAP5 MSN MSN M3XQ11_MUSPF M3XQ11_MUSPF CXCR4 CXCR4 MAPK11 MAPK11 ITGA4 ITGA4 MAPK12 MAPK12 M3XTE0_MUSPF M3XTE0_MUSPF PTPN11 PTPN11 PXN PXN GNAI3 GNAI3 VCL VCL MMP2 MMP2 CLDN1 CLDN1 CLDN16 CLDN16 MAPK14 MAPK14 MAPK13 MAPK13 M3XYN0_MUSPF M3XYN0_MUSPF M3Y080_MUSPF M3Y080_MUSPF RAP1A RAP1A CDH5 CDH5 MYL12B MYL12B MYL12A MYL12A ARHGAP35 ARHGAP35 EZR EZR TXK TXK ROCK1 ROCK1 THY1 THY1 VASP VASP ITGB1 ITGB1 MYL2 MYL2 PTK2 PTK2 M3XR07_MUSPF M3XR07_MUSPF CTNNB1 CTNNB1 ITGAM ITGAM MYL5 MYL5 M3YI89_MUSPF M3YI89_MUSPF CLDN7 CLDN7 ITGB2 ITGB2 PRKCG PRKCG BCAR1 BCAR1 CTNNA1 CTNNA1 CLDN18 CLDN18 PLCG2 PLCG2 PIK3CB PIK3CB JAM3 JAM3 CTNNA2 CTNNA2 M3YAW2_MUSPF M3YAW2_MUSPF CYBA CYBA ACTN1 ACTN1 MMP20 MMP20 ICAM1 ICAM1 RHOH RHOH CLDN9 CLDN9 M3Z8L1_MUSPF M3Z8L1_MUSPF CLDN23 CLDN23 M3Z899_MUSPF M3Z899_MUSPF M3Z898_MUSPF M3Z898_MUSPF CLDN5 CLDN5 CLDN4 CLDN4 CLDN3 CLDN3 CLDN25 CLDN25 CLDN8 CLDN8 CLDN14 CLDN14 M3Z5M2_MUSPF M3Z5M2_MUSPF CLDN20 CLDN20 CLDN2 CLDN2 GNAI1 GNAI1 MYL7 MYL7 ACTN4 ACTN4 MYL9 MYL9 PLCG1 PLCG1 MMP9 MMP9 RAP1B RAP1B CXCL12 CXCL12 PIK3CA PIK3CA M3Z091_MUSPF M3Z091_MUSPF ACTB ACTB ACTL8 ACTL8 NCF1 NCF1 M3YX33_MUSPF M3YX33_MUSPF MYL10 MYL10 CLDN15 CLDN15 M3YWQ4_MUSPF M3YWQ4_MUSPF M3YWA8_MUSPF M3YWA8_MUSPF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
AFDNAfadin, adherens junction formation factor. (1789 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
ESAMEndothelial cell adhesion molecule. (393 aa)
NOXA1NADPH oxidase activator 1. (467 aa)
PECAM1Platelet and endothelial cell adhesion molecule 1. (739 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (688 aa)
OCLNOccludin. (521 aa)
F11RF11 receptor. (270 aa)
M3YR72_MUSPFUncharacterized protein. (542 aa)
CLDN19Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (224 aa)
RHOARas homolog family member A. (193 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1389 aa)
ITKTyrosine-protein kinase. (620 aa)
GNAI2G protein subunit alpha i2. (355 aa)
M3YNJ8_MUSPFUncharacterized protein. (461 aa)
RAC2Rac family small GTPase 2. (192 aa)
NCF4Neutrophil cytosolic factor 4. (339 aa)
CYBBCytochrome b-245 beta chain. (568 aa)
XKXK-related protein. (444 aa)
MYLPFMyosin light chain, phosphorylatable, fast skeletal muscle. (170 aa)
ITGALIntegrin subunit alpha L; Belongs to the integrin alpha chain family. (1166 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (577 aa)
VAV2Vav guanine nucleotide exchange factor 2. (834 aa)
RASSF5Ras association domain family member 5. (266 aa)
VCAM1Vascular cell adhesion molecule 1. (739 aa)
M3YKK2_MUSPFUncharacterized protein. (220 aa)
M3YKJ5_MUSPFUncharacterized protein. (247 aa)
CLDN10Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (229 aa)
NCF2Neutrophil cytosolic factor 2. (620 aa)
SIPA1Signal-induced proliferation-associated 1. (1044 aa)
ACTG1Actin gamma 1. (375 aa)
CD99L2CD99 molecule like 2. (252 aa)
VAV3Vav guanine nucleotide exchange factor 3. (847 aa)
CTNND1Catenin delta 1. (967 aa)
LPXNLeupaxin; Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin- induced tyrosine phosphorylation of paxillin (PXN). (414 aa)
M3XMV4_MUSPFUncharacterized protein. (466 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (1011 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
JAM2Junctional adhesion molecule 2. (298 aa)
GABPAGA binding protein transcription factor subunit alpha. (454 aa)
ARHGAP5Rho GTPase activating protein 5. (1503 aa)
MSNMoesin. (577 aa)
M3XQ11_MUSPFUncharacterized protein. (139 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (353 aa)
MAPK11Mitogen-activated protein kinase. (434 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1033 aa)
MAPK12Mitogen-activated protein kinase. (287 aa)
M3XTE0_MUSPFUncharacterized protein; Belongs to the actin family. (348 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
PXNPaxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (590 aa)
GNAI3G protein subunit alpha i3. (354 aa)
VCLVinculin. (1134 aa)
MMP2Matrix metallopeptidase 2. (661 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
CLDN16Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (254 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
M3XYN0_MUSPFUncharacterized protein. (192 aa)
M3Y080_MUSPFUncharacterized protein. (202 aa)
RAP1ARAP1A, member of RAS oncogene family. (188 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (783 aa)
MYL12BMyosin light chain 12B. (172 aa)
MYL12AMyosin light chain 12A. (172 aa)
ARHGAP35Rho GTPase activating protein 35. (1500 aa)
EZREzrin. (586 aa)
TXKTyrosine-protein kinase. (551 aa)
ROCK1Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1252 aa)
THY1Thy-1 cell surface antigen. (161 aa)
VASPVasodilator stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (382 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
MYL2Myosin light chain 2. (166 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1096 aa)
M3XR07_MUSPFUncharacterized protein; Belongs to the actin family. (362 aa)
CTNNB1Catenin beta 1. (781 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1053 aa)
MYL5Myosin light chain 5. (172 aa)
M3YI89_MUSPFUncharacterized protein. (271 aa)
CLDN7Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
ITGB2Integrin beta. (782 aa)
PRKCGNon-specific serine/threonine protein kinase. (569 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (867 aa)
CTNNA1Catenin alpha 1. (930 aa)
CLDN18Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (259 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1266 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
JAM3Junctional adhesion molecule 3. (305 aa)
CTNNA2Catenin alpha 2. (521 aa)
M3YAW2_MUSPFUncharacterized protein. (429 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (194 aa)
ACTN1Actinin alpha 1. (914 aa)
MMP20Matrix metallopeptidase 20. (417 aa)
ICAM1Intercellular adhesion molecule 1. (589 aa)
RHOHRas homolog family member H. (191 aa)
CLDN9Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (217 aa)
M3Z8L1_MUSPFClaudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (221 aa)
CLDN23Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (291 aa)
M3Z899_MUSPFClaudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (207 aa)
M3Z898_MUSPFClaudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
CLDN5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
CLDN4Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (209 aa)
CLDN3Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
CLDN25Claudin 25. (215 aa)
CLDN8Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (225 aa)
CLDN14Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (237 aa)
M3Z5M2_MUSPFUncharacterized protein. (213 aa)
CLDN20Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (219 aa)
CLDN2Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (230 aa)
GNAI1G protein subunit alpha i1. (354 aa)
MYL7Myosin light chain 7. (175 aa)
ACTN4Actinin alpha 4. (882 aa)
MYL9Myosin light chain 9. (172 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
MMP9Matrix metallopeptidase 9. (704 aa)
RAP1BRAP1B, member of RAS oncogene family. (184 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (93 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
M3Z091_MUSPFClaudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (207 aa)
ACTBActin beta. (375 aa)
ACTL8Actin like 8; Belongs to the actin family. (366 aa)
NCF1Neutrophil cytosolic factor 1. (391 aa)
M3YX33_MUSPFUncharacterized protein. (191 aa)
MYL10Myosin light chain 10. (167 aa)
CLDN15Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (234 aa)
M3YWQ4_MUSPFUncharacterized protein; Belongs to the actin family. (338 aa)
M3YWA8_MUSPFUncharacterized protein. (726 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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