(99 nodes) Progesterone-mediated oocyte maturation network (Mustela putorius)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PLK1	Serine/threonine-protein kinase PLK. (542 aa)
	M3Z7Y4_MUSPF	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (423 aa)
	M3Z7E4_MUSPF	Uncharacterized protein. (1085 aa)
	M3Z6E6_MUSPF	Uncharacterized protein. (134 aa)
	MOS	MOS proto-oncogene, serine/threonine kinase; Belongs to the protein kinase superfamily. (348 aa)
	GNAI1	G protein subunit alpha i1. (354 aa)
	ADCY1	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1130 aa)
	REM1	GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (298 aa)
	MAD1L1	Mitotic arrest deficient 1 like 1. (737 aa)
	AKT2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
	LOC101691234	Uncharacterized protein; Belongs to the cyclin family. (361 aa)
	MAD2L1	Mitotic arrest deficient 2 like 1. (205 aa)
	CCNA2	Cyclin A2; Belongs to the cyclin family. (432 aa)
	CPEB3	Cytoplasmic polyadenylation element binding protein 3. (692 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (644 aa)
	ANAPC4	Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (807 aa)
	M3YYT7_MUSPF	Uncharacterized protein. (284 aa)
	MAD2L2	Mitotic arrest deficient 2 like 2. (211 aa)
	TMEM82	Transmembrane protein 82. (348 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa)
	M3YWA8_MUSPF	Uncharacterized protein. (726 aa)
	RPS6KA1	Ribosomal protein S6 kinase. (719 aa)
	CPEB1	Uncharacterized protein. (602 aa)
	PKMYT1	Protein kinase, membrane associated tyrosine/threonine 1; Belongs to the protein kinase superfamily. (481 aa)
	ANAPC2	Anaphase promoting complex subunit 2; Belongs to the cullin family. (818 aa)
	ADCY9	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
	CDC25A	Cell division cycle 25A. (476 aa)
	ADCY6	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
	M3YT79_MUSPF	Uncharacterized protein; Belongs to the cyclin family. (426 aa)
	CCNB3	Cyclin B3; Belongs to the cyclin family. (1346 aa)
	ADCY3	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
	PTRHD1	Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
	CDK3	Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa)
	ARAF	V-raf murine sarcoma 3611 viral oncoprotein-like protein. (606 aa)
	PDE3B	Phosphodiesterase. (889 aa)
	GNAI2	G protein subunit alpha i2. (355 aa)
	M3YNJ8_MUSPF	Uncharacterized protein. (461 aa)
	STK10	Serine/threonine kinase 10. (967 aa)
	CPEB4	Cytoplasmic polyadenylation element binding protein 4. (729 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (399 aa)
	HSP90AB1	Heat shock protein 90 alpha family class B member 1. (724 aa)
	KIF22	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (660 aa)
	IGF1	Insulin like growth factor 1. (153 aa)
	M3YIU0_MUSPF	RING-type domain-containing protein. (84 aa)
	CDK1	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
	IGF1R	Tyrosine-protein kinase receptor. (1367 aa)
	KRAS	KRAS proto-oncogene, GTPase. (208 aa)
	CDC23	Cell division cycle 23. (590 aa)
	ANAPC1	Anaphase promoting complex subunit 1. (1944 aa)
	M3YDJ4_MUSPF	Uncharacterized protein. (236 aa)
	CDC25C	Cell division cycle 25C. (491 aa)
	M3YD28_MUSPF	Uncharacterized protein. (1086 aa)
	CDC16	Cell division cycle 16. (605 aa)
	MAPK8	Mitogen-activated protein kinase. (397 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
	GEM	GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (296 aa)
	CDC25B	Cell division cycle 25B. (515 aa)
	AP5S1	Adaptor related protein complex 5 subunit sigma 1. (201 aa)
	AURKB	Aurora kinase B; Belongs to the protein kinase superfamily. (344 aa)
	CDC27	Cell division cycle 27. (825 aa)
	ADCY2	Adenylate cyclase 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (880 aa)
	ANAPC10	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa)
	RPS6KA2	Ribosomal protein S6 kinase. (733 aa)
	AURKC	Aurora kinase C; Belongs to the protein kinase superfamily. (307 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
	MAPK9	Mitogen-activated protein kinase. (398 aa)
	CDK2	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (334 aa)
	ADCY8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa)
	PGR	Progesterone receptor. (934 aa)
	CCNA1	Cyclin A1; Belongs to the cyclin family. (421 aa)
	M3XSM2_MUSPF	Uncharacterized protein. (164 aa)
	M3XSP6_MUSPF	Uncharacterized protein. (460 aa)
	ANAPC5	Anaphase promoting complex subunit 5. (711 aa)
	ANAPC7	Anaphase promoting complex subunit 7. (598 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	MAPK11	Mitogen-activated protein kinase. (434 aa)
	MAPK10	Mitogen-activated protein kinase. (384 aa)
	MAPK12	Mitogen-activated protein kinase. (287 aa)
	HSP90AA1	HATPase_c domain-containing protein. (679 aa)
	PRKACA	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
	MAPK1	Mitogen-activated protein kinase. (333 aa)
	ADCY7	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
	GNAI3	G protein subunit alpha i3. (354 aa)
	RPS6KA3	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (741 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (715 aa)
	FZR1	Fizzy and cell division cycle 20 related 1. (493 aa)
	MAPK14	Mitogen-activated protein kinase. (360 aa)
	MAPK13	Mitogen-activated protein kinase. (366 aa)
	CCNB2	Cyclin B2; Belongs to the cyclin family. (397 aa)
	ADCY5	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1018 aa)
	RRAD	GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (109 aa)
	ADCY4	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1105 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
	AURKA	Aurora kinase A; Belongs to the protein kinase superfamily. (405 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
	RPS6KA6	Ribosomal protein S6 kinase. (794 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY1	ADCY2	ENSMPUP00000018070	ENSMPUP00000007102	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.572
ADCY1	ADCY3	ENSMPUP00000018070	ENSMPUP00000013920	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.833
ADCY1	ADCY4	ENSMPUP00000018070	ENSMPUP00000005626	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.564
ADCY1	ADCY5	ENSMPUP00000018070	ENSMPUP00000004470	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.548
ADCY1	ADCY6	ENSMPUP00000018070	ENSMPUP00000014639	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.550
ADCY1	ADCY7	ENSMPUP00000018070	ENSMPUP00000003122	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.655
ADCY1	ADCY8	ENSMPUP00000018070	ENSMPUP00000001384	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.855
ADCY1	ADCY9	ENSMPUP00000018070	ENSMPUP00000014921	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.620
ADCY1	AKT1	ENSMPUP00000018070	ENSMPUP00000002136	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.795
ADCY1	AKT2	ENSMPUP00000018070	ENSMPUP00000017599	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.795
ADCY1	AKT3	ENSMPUP00000018070	ENSMPUP00000015621	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.844
ADCY1	ANAPC5	ENSMPUP00000018070	ENSMPUP00000002097	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Anaphase promoting complex subunit 5.	0.511
ADCY1	ANAPC7	ENSMPUP00000018070	ENSMPUP00000002125	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Anaphase promoting complex subunit 7.	0.511
ADCY1	GNAI1	ENSMPUP00000018070	ENSMPUP00000018173	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i1.	0.822
ADCY1	GNAI2	ENSMPUP00000018070	ENSMPUP00000013014	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i2.	0.822
ADCY1	GNAI3	ENSMPUP00000018070	ENSMPUP00000003264	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i3.	0.822
ADCY1	PDE3B	ENSMPUP00000018070	ENSMPUP00000013144	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Phosphodiesterase.	0.880
ADCY1	PRKACA	ENSMPUP00000018070	ENSMPUP00000003045	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.878
ADCY1	PRKACB	ENSMPUP00000018070	ENSMPUP00000005718	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.882
ADCY1	PTRHD1	ENSMPUP00000018070	ENSMPUP00000013910	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Peptidyl-tRNA hydrolase domain containing 1.	0.833