(65 nodes) Regulation of lipolysis in adipocytes network (Mustela putorius)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	PTRHD1	Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
	ADCY3	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
	ADRB2	Adrenoceptor beta 2. (408 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
	ADCY6	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
	PRKG2	cGMP-dependent protein kinase. (783 aa)
	ADCY9	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
	M3YW64_MUSPF	Uncharacterized protein. (513 aa)
	M3YWA8_MUSPF	Uncharacterized protein. (726 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa)
	PTGER3	Prostaglandin E receptor 3. (389 aa)
	IRS1	Insulin receptor substrate 1. (1428 aa)
	ADCY8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa)
	TSHB	Thyroid stimulating hormone subunit beta. (138 aa)
	M3XRM2_MUSPF	Uncharacterized protein. (74 aa)
	M3XRM4_MUSPF	Uncharacterized protein. (239 aa)
	M3XRN2_MUSPF	Uncharacterized protein. (90 aa)
	FABP12	Fatty acid binding protein 12; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (149 aa)
	FABP4	Fatty acid binding protein 4; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
	FABP9	Fatty acid binding protein 9; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
	PMP2	Peripheral myelin protein 2; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
	NPY1R	Neuropeptide Y receptor Y1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	PRKACA	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
	ADCY7	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
	GNAI3	G protein subunit alpha i3. (354 aa)
	IRS4	Insulin receptor substrate 4. (1259 aa)
	M3XYB6_MUSPF	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (334 aa)
	ADCY5	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1018 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (109 aa)
	ADCY4	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1105 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
	M3Y334_MUSPF	Uncharacterized protein. (312 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
	M3Z5X4_MUSPF	Uncharacterized protein. (338 aa)
	GNAI1	G protein subunit alpha i1. (354 aa)
	ADCY1	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1130 aa)
	AKT2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
	MGLL	Monoglyceride lipase. (317 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	M3YZV5_MUSPF	Cyclic nucleotide-binding domain-containing protein. (159 aa)
	PRKG1	Protein kinase cGMP-dependent 1; Belongs to the protein kinase superfamily. (471 aa)
	NPPA	Natriuretic peptide A. (163 aa)
	PLIN1	Perilipin; Belongs to the perilipin family. (480 aa)
	M3Y692_MUSPF	Uncharacterized protein. (362 aa)
	ADCY2	Adenylate cyclase 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (880 aa)
	PTGS1	Prostaglandin-endoperoxide synthase 1. (599 aa)
	LIPE	Lipase E, hormone sensitive type. (797 aa)
	NPR1	Guanylate cyclase. (1057 aa)
	INSR	Tyrosine-protein kinase receptor. (1352 aa)
	TSHR	Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (784 aa)
	PNPLA2	Patatin like phospholipase domain containing 2. (482 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
	CGA	Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (120 aa)
	M3YEU4_MUSPF	G_PROTEIN_RECEP_F1_2 domain-containing protein. (435 aa)
	PTGS2	Prostaglandin-endoperoxide synthase 2. (604 aa)
	M3YIA6_MUSPF	Uncharacterized protein. (333 aa)
	ADORA1	Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (326 aa)
	ABHD5	Abhydrolase domain containing 5. (349 aa)
	M3YNJ8_MUSPF	Uncharacterized protein. (461 aa)
	GNAI2	G protein subunit alpha i2. (355 aa)
	PDE3B	Phosphodiesterase. (889 aa)
	NPY	Neuropeptide Y. (97 aa)
	M3YPW6_MUSPF	LRAT domain-containing protein. (162 aa)
	M3YPW9_MUSPF	LRAT domain-containing protein. (162 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABHD5	LIPE	ENSMPUP00000012832	ENSMPUP00000008183	Abhydrolase domain containing 5.	Lipase E, hormone sensitive type.	0.552
ABHD5	MGLL	ENSMPUP00000012832	ENSMPUP00000017234	Abhydrolase domain containing 5.	Monoglyceride lipase.	0.563
ABHD5	PLIN1	ENSMPUP00000012832	ENSMPUP00000015649	Abhydrolase domain containing 5.	Perilipin; Belongs to the perilipin family.	0.920
ABHD5	PNPLA2	ENSMPUP00000012832	ENSMPUP00000009002	Abhydrolase domain containing 5.	Patatin like phospholipase domain containing 2.	0.979
ADCY1	ADCY2	ENSMPUP00000018070	ENSMPUP00000007102	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.572
ADCY1	ADCY3	ENSMPUP00000018070	ENSMPUP00000013920	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.833
ADCY1	ADCY4	ENSMPUP00000018070	ENSMPUP00000005626	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.564
ADCY1	ADCY5	ENSMPUP00000018070	ENSMPUP00000004470	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.548
ADCY1	ADCY6	ENSMPUP00000018070	ENSMPUP00000014639	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.550
ADCY1	ADCY7	ENSMPUP00000018070	ENSMPUP00000003122	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.655
ADCY1	ADCY8	ENSMPUP00000018070	ENSMPUP00000001384	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.855
ADCY1	ADCY9	ENSMPUP00000018070	ENSMPUP00000014921	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.620
ADCY1	AKT1	ENSMPUP00000018070	ENSMPUP00000002136	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.795
ADCY1	AKT2	ENSMPUP00000018070	ENSMPUP00000017599	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.795
ADCY1	AKT3	ENSMPUP00000018070	ENSMPUP00000015621	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.844
ADCY1	GNAI1	ENSMPUP00000018070	ENSMPUP00000018173	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i1.	0.822
ADCY1	GNAI2	ENSMPUP00000018070	ENSMPUP00000013014	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i2.	0.822
ADCY1	GNAI3	ENSMPUP00000018070	ENSMPUP00000003264	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i3.	0.822
ADCY1	M3Y692_MUSPF	ENSMPUP00000018070	ENSMPUP00000006843	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.901
ADCY1	M3YZV5_MUSPF	ENSMPUP00000018070	ENSMPUP00000016866	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Cyclic nucleotide-binding domain-containing protein.	0.430