(53 nodes) Type II diabetes mellitus network (Mustela putorius)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	HK3	Hexokinase 3. (924 aa)
	SOCS1	Suppressor of cytokine signaling 1. (216 aa)
	SOCS3	Suppressor of cytokine signaling 3. (225 aa)
	SOCS4	Suppressor of cytokine signaling 4. (441 aa)
	KCNJ11	Potassium voltage-gated channel subfamily J member 11. (390 aa)
	GCK	Phosphotransferase. (473 aa)
	CACNA1C	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1479 aa)
	M3Z2Z7_MUSPF	Uncharacterized protein. (204 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	TNIK	TRAF2 and NCK interacting kinase. (1360 aa)
	PARP6	Poly [ADP-ribose] polymerase. (741 aa)
	PKM	Pyruvate kinase; Belongs to the pyruvate kinase family. (579 aa)
	SLC2A2	Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (508 aa)
	CACNA1D	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2217 aa)
	PRKCD	Protein kinase C. (730 aa)
	M3YZ57_MUSPF	Uncharacterized protein. (168 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2552 aa)
	M3YWA8_MUSPF	Uncharacterized protein. (726 aa)
	M3YW64_MUSPF	Uncharacterized protein. (513 aa)
	CACNA1G	Calcium voltage-gated channel subunit alpha1 G. (2177 aa)
	CACNA1B	Calcium voltage-gated channel subunit alpha1 B. (1971 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
	PARP8	Poly [ADP-ribose] polymerase. (893 aa)
	ABCC8	ATP binding cassette subfamily C member 8. (1581 aa)
	M3YNJ8_MUSPF	Uncharacterized protein. (461 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (399 aa)
	PRKCE	Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (736 aa)
	CACNA1E	Voltage-dependent R-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. (2463 aa)
	TNF	Tumor necrosis factor alpha; Belongs to the tumor necrosis factor family. (233 aa)
	M3YIA6_MUSPF	Uncharacterized protein. (333 aa)
	SLC2A4	Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
	MAPK8	Mitogen-activated protein kinase. (397 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
	INSR	Tyrosine-protein kinase receptor. (1352 aa)
	HK2	Hexokinase 2. (917 aa)
	PRKCZ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (582 aa)
	SOCS2	Suppressor of cytokine signaling 2. (198 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (109 aa)
	PKLR	Pyruvate kinase; Belongs to the pyruvate kinase family. (574 aa)
	PDX1	Pancreatic and duodenal homeobox 1. (283 aa)
	M3XZF1_MUSPF	Phosphotransferase. (133 aa)
	HKDC1	Hexokinase domain containing 1. (704 aa)
	HK1	Hexokinase 1. (917 aa)
	IRS4	Insulin receptor substrate 4. (1259 aa)
	M3XXC7_MUSPF	Uncharacterized protein. (93 aa)
	CACNA1A	Voltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2496 aa)
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (244 aa)
	MAPK1	Mitogen-activated protein kinase. (333 aa)
	MAPK10	Mitogen-activated protein kinase. (384 aa)
	IRS1	Insulin receptor substrate 1. (1428 aa)
	MAPK9	Mitogen-activated protein kinase. (398 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCC8	GCK	ENSMPUP00000013269	ENSMPUP00000018089	ATP binding cassette subfamily C member 8.	Phosphotransferase.	0.477
ABCC8	INS	ENSMPUP00000013269	ENSMPUP00000005593	ATP binding cassette subfamily C member 8.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.458
ABCC8	KCNJ11	ENSMPUP00000013269	ENSMPUP00000018880	ATP binding cassette subfamily C member 8.	Potassium voltage-gated channel subfamily J member 11.	0.999
ABCC8	SLC2A2	ENSMPUP00000013269	ENSMPUP00000017007	ATP binding cassette subfamily C member 8.	Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.	0.622
ADIPOQ	INS	ENSMPUP00000003314	ENSMPUP00000005593	Adiponectin, C1Q and collagen domain containing.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.771
ADIPOQ	INSR	ENSMPUP00000003314	ENSMPUP00000008382	Adiponectin, C1Q and collagen domain containing.	Tyrosine-protein kinase receptor.	0.421
ADIPOQ	SLC2A4	ENSMPUP00000003314	ENSMPUP00000010333	Adiponectin, C1Q and collagen domain containing.	Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.	0.760
ADIPOQ	TNF	ENSMPUP00000003314	ENSMPUP00000011297	Adiponectin, C1Q and collagen domain containing.	Tumor necrosis factor alpha; Belongs to the tumor necrosis factor family.	0.598
CACNA1A	CACNA1B	ENSMPUP00000003326	ENSMPUP00000015171	Voltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents.	Calcium voltage-gated channel subunit alpha1 B.	0.945
CACNA1A	CACNA1C	ENSMPUP00000003326	ENSMPUP00000017960	Voltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents.	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.	0.840
CACNA1A	CACNA1D	ENSMPUP00000003326	ENSMPUP00000016713	Voltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents.	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.	0.841
CACNA1A	CACNA1E	ENSMPUP00000003326	ENSMPUP00000011400	Voltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents.	Voltage-dependent R-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents.	0.951
CACNA1A	CACNA1G	ENSMPUP00000003326	ENSMPUP00000015390	Voltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents.	Calcium voltage-gated channel subunit alpha1 G.	0.688
CACNA1A	KCNJ11	ENSMPUP00000003326	ENSMPUP00000018880	Voltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents.	Potassium voltage-gated channel subfamily J member 11.	0.479
CACNA1A	M3XXC7_MUSPF	ENSMPUP00000003326	ENSMPUP00000003727	Voltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents.	Uncharacterized protein.	0.745
CACNA1A	M3YZ57_MUSPF	ENSMPUP00000003326	ENSMPUP00000016617	Voltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents.	Uncharacterized protein.	0.874
CACNA1A	M3Z2Z7_MUSPF	ENSMPUP00000003326	ENSMPUP00000017959	Voltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents.	Uncharacterized protein.	0.830
CACNA1B	CACNA1A	ENSMPUP00000015171	ENSMPUP00000003326	Calcium voltage-gated channel subunit alpha1 B.	Voltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents.	0.945
CACNA1B	CACNA1C	ENSMPUP00000015171	ENSMPUP00000017960	Calcium voltage-gated channel subunit alpha1 B.	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.	0.776
CACNA1B	CACNA1D	ENSMPUP00000015171	ENSMPUP00000016713	Calcium voltage-gated channel subunit alpha1 B.	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.	0.780