STRINGSTRING
UQCRQ UQCRQ M3YFZ4_MUSPF M3YFZ4_MUSPF M3YFY6_MUSPF M3YFY6_MUSPF MLX MLX M3YEN4_MUSPF M3YEN4_MUSPF IL1A IL1A M3YE34_MUSPF M3YE34_MUSPF BCL2L11 BCL2L11 NFKB1 NFKB1 EIF2AK3 EIF2AK3 CXCL8 CXCL8 NDUFA9 NDUFA9 FOS FOS MAPK8 MAPK8 PIK3CB PIK3CB PRKAG2 PRKAG2 M3YBU8_MUSPF M3YBU8_MUSPF M3YBI3_MUSPF M3YBI3_MUSPF INSR INSR GSK3B GSK3B M3YA53_MUSPF M3YA53_MUSPF NDUFS7 NDUFS7 M3Y956_MUSPF M3Y956_MUSPF KIAA1958 KIAA1958 M3Y8H5_MUSPF M3Y8H5_MUSPF CEBPA CEBPA COX6B2 COX6B2 M3Y830_MUSPF M3Y830_MUSPF M3Y812_MUSPF M3Y812_MUSPF NDUFA12 NDUFA12 IL6R IL6R M3Y7D8_MUSPF M3Y7D8_MUSPF NDUFA8 NDUFA8 PRKAA2 PRKAA2 CYC1 CYC1 EIF2S1 EIF2S1 NDUFA5 NDUFA5 LEP LEP FAS FAS COX6B1 COX6B1 PIK3CD PIK3CD M3Y496_MUSPF M3Y496_MUSPF INS INS COX7A1 COX7A1 PKLR PKLR NR1H3 NR1H3 NDUFV2 NDUFV2 C7orf31 C7orf31 NDUFB6 NDUFB6 M3XYN0_MUSPF M3XYN0_MUSPF NDUFS8 NDUFS8 NDUFV1 NDUFV1 NDUFS3 NDUFS3 M3XX15_MUSPF M3XX15_MUSPF M3XWE3_MUSPF M3XWE3_MUSPF ADIPOQ ADIPOQ BAX BAX M3XVS8_MUSPF M3XVS8_MUSPF NDUFB7 NDUFB7 PRKAB1 PRKAB1 CYP2E1 CYP2E1 MAPK10 MAPK10 AKT1 AKT1 MLXIP MLXIP CASP7 CASP7 DDIT3 DDIT3 NDUFA4L2 NDUFA4L2 M3XR15_MUSPF M3XR15_MUSPF NDUFB9 NDUFB9 IRS1 IRS1 LEPR LEPR PRKAB2 PRKAB2 MAPK9 MAPK9 NDUFS1 NDUFS1 CASP8 CASP8 NDUFA10 NDUFA10 SREBF1 SREBF1 JUN JUN M3Z8A7_MUSPF M3Z8A7_MUSPF SOCS3 SOCS3 M3Z772_MUSPF M3Z772_MUSPF M3Z6L6_MUSPF M3Z6L6_MUSPF M3Z6D6_MUSPF M3Z6D6_MUSPF M3Z5P7_MUSPF M3Z5P7_MUSPF COX7B2 COX7B2 M3Z522_MUSPF M3Z522_MUSPF M3Z4Y0_MUSPF M3Z4Y0_MUSPF M3Z3Y7_MUSPF M3Z3Y7_MUSPF M3Z3T8_MUSPF M3Z3T8_MUSPF M3Z346_MUSPF M3Z346_MUSPF ADIPOR2 ADIPOR2 COX4I2 COX4I2 ITCH ITCH AKT2 AKT2 TGFB1 TGFB1 COX5A COX5A NDUFB5 NDUFB5 PIK3CA PIK3CA M3YZU4_MUSPF M3YZU4_MUSPF TNFRSF1A TNFRSF1A M3YZI5_MUSPF M3YZI5_MUSPF M3YZI4_MUSPF M3YZI4_MUSPF PRKAG3 PRKAG3 NDUFA6 NDUFA6 M3YXT4_MUSPF M3YXT4_MUSPF PPARA PPARA NDUFC1 NDUFC1 MLXIPL MLXIPL M3YX33_MUSPF M3YX33_MUSPF AKT3 AKT3 M3YWA8_MUSPF M3YWA8_MUSPF FASLG FASLG NDUFB10 NDUFB10 YJEFN3 YJEFN3 MAP3K5 MAP3K5 ERN1 ERN1 PRKAA1 PRKAA1 PIK3R1 PIK3R1 PRKAG1 PRKAG1 UQCRC1 UQCRC1 SDHC SDHC NDUFS4 NDUFS4 NDUFS2 NDUFS2 NDUFA4 NDUFA4 IL6 IL6 M3YQ14_MUSPF M3YQ14_MUSPF M3YPM9_MUSPF M3YPM9_MUSPF UQCR10 UQCR10 NDUFB11 NDUFB11 M3YNJ8_MUSPF M3YNJ8_MUSPF M3YN20_MUSPF M3YN20_MUSPF IKBKB IKBKB RXRA RXRA NDUFAB1 NDUFAB1 MAP3K11 MAP3K11 RELA RELA TNF TNF COX6A2 COX6A2 COX5B COX5B ADIPOR1 ADIPOR1 M3YIA6_MUSPF M3YIA6_MUSPF CASP3 CASP3 TRAF2 TRAF2 IL1B IL1B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
UQCRQUbiquinol-cytochrome c reductase complex III subunit VII. (100 aa)
M3YFZ4_MUSPFSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (551 aa)
M3YFY6_MUSPFUncharacterized protein. (84 aa)
MLXMAX dimerization protein MLX. (286 aa)
M3YEN4_MUSPFBZIP domain-containing protein. (358 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (270 aa)
M3YE34_MUSPFUncharacterized protein. (574 aa)
BCL2L11BCL2 like 11. (232 aa)
NFKB1Nuclear factor kappa B subunit 1. (971 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1065 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
NDUFA9NADH:ubiquinone oxidoreductase subunit A9. (377 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (446 aa)
MAPK8Mitogen-activated protein kinase. (397 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (529 aa)
M3YBU8_MUSPFUncharacterized protein. (136 aa)
M3YBI3_MUSPFCytochrome b-c1 complex subunit 7; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain; Belongs to the UQCRB/QCR7 family. (132 aa)
INSRTyrosine-protein kinase receptor. (1352 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (420 aa)
M3YA53_MUSPFUncharacterized protein. (140 aa)
NDUFS7NADH:ubiquinone oxidoreductase core subunit S7; Belongs to the complex I 20 kDa subunit family. (226 aa)
M3Y956_MUSPFNADH dehydrogenase [ubiquinone] 1 subunit C2; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (120 aa)
KIAA1958KIAA1958. (716 aa)
M3Y8H5_MUSPFCOX2_CUA domain-containing protein. (36 aa)
CEBPACCAAT/enhancer-binding protein. (268 aa)
COX6B2Cytochrome c oxidase subunit; Belongs to the cytochrome c oxidase subunit 6B. (88 aa)
M3Y830_MUSPFProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (417 aa)
M3Y812_MUSPFDUF3699 domain-containing protein. (597 aa)
NDUFA12NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (191 aa)
IL6RInterleukin 6 receptor. (436 aa)
M3Y7D8_MUSPFUncharacterized protein. (122 aa)
NDUFA8NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (172 aa)
PRKAA2Non-specific serine/threonine protein kinase. (524 aa)
CYC1Cytochrome c1. (323 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit alpha. (315 aa)
NDUFA5NADH:ubiquinone oxidoreductase subunit A5. (116 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (166 aa)
FASFas cell surface death receptor. (311 aa)
COX6B1Cytochrome c oxidase subunit; Belongs to the cytochrome c oxidase subunit 6B. (86 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
M3Y496_MUSPFUncharacterized protein. (141 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (109 aa)
COX7A1Cytochrome c oxidase subunit 7A1. (80 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (574 aa)
NR1H3Nuclear receptor subfamily 1 group H member 3. (447 aa)
NDUFV2NADH:ubiquinone oxidoreductase core subunit V2. (231 aa)
C7orf31Chromosome 7 open reading frame 31. (589 aa)
NDUFB6NADH:ubiquinone oxidoreductase subunit B6. (128 aa)
M3XYN0_MUSPFUncharacterized protein. (192 aa)
NDUFS8NADH-ubiquinone oxidoreductase 23 kDa subunit, mitochondrial. (210 aa)
NDUFV1NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. (464 aa)
NDUFS3NADH:ubiquinone oxidoreductase core subunit S3; Belongs to the complex I 30 kDa subunit family. (266 aa)
M3XX15_MUSPFSuccinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (270 aa)
M3XWE3_MUSPFUncharacterized protein. (109 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
M3XVS8_MUSPFCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
NDUFB7NADH:ubiquinone oxidoreductase subunit B7. (137 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
CYP2E1Cytochrome P450 family 2 subfamily E member 1; Belongs to the cytochrome P450 family. (444 aa)
MAPK10Mitogen-activated protein kinase. (384 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
MLXIPMLX interacting protein. (834 aa)
CASP7Caspase 7; Belongs to the peptidase C14A family. (301 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
NDUFA4L2NDUFA4 mitochondrial complex associated like 2. (87 aa)
M3XR15_MUSPFUncharacterized protein. (255 aa)
NDUFB9NADH:ubiquinone oxidoreductase subunit B9; Belongs to the complex I LYR family. (179 aa)
IRS1Insulin receptor substrate 1. (1428 aa)
LEPRLeptin receptor. (1164 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (296 aa)
MAPK9Mitogen-activated protein kinase. (398 aa)
NDUFS1NADH:ubiquinone oxidoreductase core subunit S1; Belongs to the complex I 75 kDa subunit family. (728 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (484 aa)
NDUFA10NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (355 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1147 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
M3Z8A7_MUSPFUncharacterized protein. (110 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
M3Z772_MUSPFUncharacterized protein. (114 aa)
M3Z6L6_MUSPFUncharacterized protein. (129 aa)
M3Z6D6_MUSPFCytochrome b-c1 complex subunit 7; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain; Belongs to the UQCRB/QCR7 family. (111 aa)
M3Z5P7_MUSPFUncharacterized protein. (70 aa)
COX7B2Cytochrome c oxidase subunit 7B2. (80 aa)
M3Z522_MUSPFUncharacterized protein. (84 aa)
M3Z4Y0_MUSPFCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
M3Z3Y7_MUSPFCytochrome b-c1 complex subunit 7; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain; Belongs to the UQCRB/QCR7 family. (111 aa)
M3Z3T8_MUSPFUncharacterized protein. (84 aa)
M3Z346_MUSPFzf-CHCC domain-containing protein. (125 aa)
ADIPOR2Adiponectin receptor 2. (385 aa)
COX4I2Cytochrome c oxidase subunit 4I2. (169 aa)
ITCHE3 ubiquitin-protein ligase. (880 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
COX5ACytochrome c oxidase polypeptide Va, mitochondrial. (152 aa)
NDUFB5NADH:ubiquinone oxidoreductase subunit B5. (242 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
M3YZU4_MUSPFNADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (186 aa)
TNFRSF1ATNF receptor superfamily member 1A. (501 aa)
M3YZI5_MUSPFPeptidase_M16 domain-containing protein. (130 aa)
M3YZI4_MUSPFPeptidase_M16 domain-containing protein. (125 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (488 aa)
NDUFA6NADH:ubiquinone oxidoreductase subunit A6; Belongs to the complex I LYR family. (147 aa)
M3YXT4_MUSPFSuccinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (280 aa)
PPARAPeroxisome proliferator activated receptor alpha. (468 aa)
NDUFC1NADH:ubiquinone oxidoreductase subunit C1. (76 aa)
MLXIPLMLX interacting protein like. (857 aa)
M3YX33_MUSPFUncharacterized protein. (191 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa)
M3YWA8_MUSPFUncharacterized protein. (726 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (275 aa)
NDUFB10NADH:ubiquinone oxidoreductase subunit B10. (176 aa)
YJEFN3YjeF N-terminal domain-containing protein. (303 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1398 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (975 aa)
PRKAA1Non-specific serine/threonine protein kinase. (517 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (329 aa)
UQCRC1Ubiquinol-cytochrome c reductase core protein 1. (480 aa)
SDHCSuccinate dehydrogenase complex subunit C. (169 aa)
NDUFS4NADH:ubiquinone oxidoreductase subunit S4. (127 aa)
NDUFS2NADH:ubiquinone oxidoreductase core subunit S2. (434 aa)
NDUFA4NDUFA4 mitochondrial complex associated. (82 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (210 aa)
M3YQ14_MUSPFBZIP domain-containing protein. (346 aa)
M3YPM9_MUSPFBZIP domain-containing protein. (351 aa)
UQCR10Ubiquinol-cytochrome c reductase, complex III subunit X. (64 aa)
NDUFB11NADH:ubiquinone oxidoreductase subunit B11. (159 aa)
M3YNJ8_MUSPFUncharacterized protein. (461 aa)
M3YN20_MUSPFCytochrome b-c1 complex subunit 6; This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1. Belongs to the UQCRH/QCR6 family. (91 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
RXRARetinoid X receptor alpha. (548 aa)
NDUFAB1Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (156 aa)
MAP3K11Mitogen-activated protein kinase kinase kinase. (863 aa)
RELARELA proto-oncogene, NF-kB subunit. (511 aa)
TNFTumor necrosis factor alpha; Belongs to the tumor necrosis factor family. (233 aa)
COX6A2Cytochrome c oxidase subunit 6A2. (70 aa)
COX5BCytochrome c oxidase subunit 5B. (129 aa)
ADIPOR1Adiponectin receptor 1. (375 aa)
M3YIA6_MUSPFUncharacterized protein. (333 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (569 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (168 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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