STRINGSTRING
COL4A1 COL4A1 CASP3 CASP3 IL1B IL1B M3YH29_MUSPF M3YH29_MUSPF COL4A2 COL4A2 STAT5B STAT5B STAT5A STAT5A STAT3 STAT3 NOX4 NOX4 KRAS KRAS AGER AGER M3YEF8_MUSPF M3YEF8_MUSPF JUN JUN AGTR1 AGTR1 THBD THBD AKT2 AKT2 PLCG1 PLCG1 TGFB1 TGFB1 SMAD3 SMAD3 MAPK9 MAPK9 EDN1 EDN1 SMAD2 SMAD2 COL4A4 COL4A4 COL4A3 COL4A3 MFF MFF COL1A2 COL1A2 CDK4 CDK4 NOX3 NOX3 AKT1 AKT1 NOX1 NOX1 MAPK11 MAPK11 MAPK10 MAPK10 MAPK12 MAPK12 VEGFD VEGFD PLCD1 PLCD1 MAPK1 MAPK1 BAX BAX F3 F3 MMP2 MMP2 COL4A6 COL4A6 MAPK14 MAPK14 COL4A5 COL4A5 MAPK13 MAPK13 M3XYN0_MUSPF M3XYN0_MUSPF TGFB2 TGFB2 CCND1 CCND1 AGT AGT JAK2 JAK2 M3Y2Z6_MUSPF M3Y2Z6_MUSPF CSDE1 CSDE1 PIK3CD PIK3CD PLCB1 PLCB1 PLCB4 PLCB4 TGFBR1 TGFBR1 ICAM1 ICAM1 IL1A IL1A NFKB1 NFKB1 EGR1 EGR1 PLCG2 PLCG2 CXCL8 CXCL8 MAPK8 MAPK8 PIK3CB PIK3CB SMAD4 SMAD4 PLCD3 PLCD3 PLCB2 PLCB2 DIAPH1 DIAPH1 PRKCZ PRKCZ FN1 FN1 NOS3 NOS3 MMP20 MMP20 PIK3CA PIK3CA PLCE1 PLCE1 PRKCD PRKCD NFATC1 NFATC1 PLCD4 PLCD4 BCL2 BCL2 M3YX33_MUSPF M3YX33_MUSPF SERPINE1 SERPINE1 AKT3 AKT3 M3YWA8_MUSPF M3YWA8_MUSPF SELE SELE COL1A1 COL1A1 CCL2 CCL2 PIK3R1 PIK3R1 PRKCA PRKCA PIM1 PIM1 IL6 IL6 VEGFB VEGFB M3YNJ8_MUSPF M3YNJ8_MUSPF PLCB3 PLCB3 VEGFA VEGFA MAPK3 MAPK3 STAT1 STAT1 CYBB CYBB XK XK COL3A1 COL3A1 PRKCB PRKCB VEGFC VEGFC VCAM1 VCAM1 PRKCE PRKCE TGFBR2 TGFBR2 RELA RELA TNF TNF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
COL4A1Collagen type IV alpha 1 chain. (1674 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (168 aa)
M3YH29_MUSPFUncharacterized protein. (180 aa)
COL4A2Collagen type IV alpha 2 chain. (1718 aa)
STAT5BSignal transducer and activator of transcription. (691 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
NOX4NADPH oxidase 4. (578 aa)
KRASKRAS proto-oncogene, GTPase. (208 aa)
AGERAdvanced glycosylation end-product specific receptor. (400 aa)
M3YEF8_MUSPFFOXO-TAD domain-containing protein. (399 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (359 aa)
THBDThrombomodulin. (567 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
SMAD3Mothers against decapentaplegic homolog. (414 aa)
MAPK9Mitogen-activated protein kinase. (398 aa)
EDN1Endothelin 1. (202 aa)
SMAD2Mothers against decapentaplegic homolog. (495 aa)
COL4A4Collagen type IV alpha 4 chain. (1693 aa)
COL4A3Collagen type IV alpha 3 chain. (1669 aa)
MFFMitochondrial fission factor. (353 aa)
COL1A2Collagen type I alpha 2 chain. (1367 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (305 aa)
NOX3NADPH oxidase 3. (573 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
NOX1NADPH oxidase 1. (589 aa)
MAPK11Mitogen-activated protein kinase. (434 aa)
MAPK10Mitogen-activated protein kinase. (384 aa)
MAPK12Mitogen-activated protein kinase. (287 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
PLCD1Phosphoinositide phospholipase C. (756 aa)
MAPK1Mitogen-activated protein kinase. (333 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
F3Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. (292 aa)
MMP2Matrix metallopeptidase 2. (661 aa)
COL4A6Collagen type IV alpha 6 chain. (1501 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
COL4A5Collagen type IV alpha 5 chain. (1691 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
M3XYN0_MUSPFUncharacterized protein. (192 aa)
TGFB2Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] (414 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
JAK2Tyrosine-protein kinase. (1130 aa)
M3Y2Z6_MUSPFUncharacterized protein. (189 aa)
CSDE1Cold shock domain containing E1. (784 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1096 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (480 aa)
ICAM1Intercellular adhesion molecule 1. (589 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (270 aa)
NFKB1Nuclear factor kappa B subunit 1. (971 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1266 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
MAPK8Mitogen-activated protein kinase. (397 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
PLCD3Phosphoinositide phospholipase C. (780 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1187 aa)
DIAPH1Diaphanous related formin 1. (1281 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (582 aa)
FN1Fibronectin 1. (2387 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1211 aa)
MMP20Matrix metallopeptidase 20. (417 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PLCE1Phosphoinositide phospholipase C. (2292 aa)
PRKCDProtein kinase C. (730 aa)
NFATC1Nuclear factor of activated T cells 1. (701 aa)
PLCD4Phosphoinositide phospholipase C. (798 aa)
BCL2BCL2 apoptosis regulator. (207 aa)
M3YX33_MUSPFUncharacterized protein. (191 aa)
SERPINE1Serpin peptidase inhibitor, clade E, member 1; Belongs to the serpin family. (400 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa)
M3YWA8_MUSPFUncharacterized protein. (726 aa)
SELESelectin E. (609 aa)
COL1A1Collagen type I alpha 1 chain. (1460 aa)
CCL2C-C motif chemokine. (101 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (688 aa)
PIM1Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (313 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (210 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (188 aa)
M3YNJ8_MUSPFUncharacterized protein. (461 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1233 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (398 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (399 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
CYBBCytochrome b-245 beta chain. (568 aa)
XKXK-related protein. (444 aa)
COL3A1Collagen type III alpha 1 chain. (1466 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (577 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (370 aa)
VCAM1Vascular cell adhesion molecule 1. (739 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (736 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (445 aa)
RELARELA proto-oncogene, NF-kB subunit. (511 aa)
TNFTumor necrosis factor alpha; Belongs to the tumor necrosis factor family. (233 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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