(73 nodes) Amphetamine addiction network (Mustela putorius)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GRIA3	Glutamate ionotropic receptor AMPA type subunit 3. (894 aa)
	PPP1CC	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
	PRKACA	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
	SLC18A2	Solute carrier family 18 member A2. (517 aa)
	CAMK2G	Calcium/calmodulin dependent protein kinase II gamma. (561 aa)
	PPP3CB	Serine/threonine-protein phosphatase. (479 aa)
	JUN	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
	M3Z785_MUSPF	Uncharacterized protein; Belongs to the calmodulin family. (149 aa)
	CALML5	Calmodulin like 5. (149 aa)
	PPP3CC	Serine/threonine-protein phosphatase. (525 aa)
	M3XXC7_MUSPF	Uncharacterized protein. (93 aa)
	PPP1CA	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
	CREB3L2	cAMP responsive element binding protein 3 like 2. (520 aa)
	GRIN2D	Glutamate ionotropic receptor NMDA type subunit 2D; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (738 aa)
	SLC18A1	Solute carrier family 18 member A1. (524 aa)
	ADCY5	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1018 aa)
	CREB3L3	cAMP responsive element binding protein 3 like 3. (473 aa)
	CREB5	cAMP responsive element binding protein 5. (275 aa)
	CALM3	Calmodulin 3; Belongs to the calmodulin family. (151 aa)
	CREB3	cAMP responsive element binding protein 3. (353 aa)
	TH	Tyrosine hydroxylase. (495 aa)
	CREB3L1	cAMP responsive element binding protein 3 like 1. (520 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
	GRIA2	Glutamate ionotropic receptor AMPA type subunit 2. (883 aa)
	FOSB	FosB proto-oncogene, AP-1 transcription factor subunit. (338 aa)
	M3Y4E6_MUSPF	Uncharacterized protein. (160 aa)
	GRIA4	Glutamate ionotropic receptor AMPA type subunit 4. (902 aa)
	M3Y692_MUSPF	Uncharacterized protein. (362 aa)
	GRIN3A	Glutamate ionotropic receptor NMDA type subunit 3A. (1135 aa)
	SLC6A3	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (626 aa)
	CREB3L4	cAMP responsive element binding protein 3 like 4. (386 aa)
	CALML6	Calmodulin like 6. (156 aa)
	CALM1	Calmodulin 1; Belongs to the calmodulin family. (156 aa)
	M3YA76_MUSPF	Protein kinase domain-containing protein. (533 aa)
	FOS	Fos proto-oncogene, AP-1 transcription factor subunit. (446 aa)
	GRIN3B	Glutamate ionotropic receptor NMDA type subunit 3B; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (945 aa)
	PPP3CA	Serine/threonine-protein phosphatase. (461 aa)
	PDYN	Prodynorphin. (257 aa)
	M3YEN4_MUSPF	BZIP domain-containing protein. (358 aa)
	PRKCG	Non-specific serine/threonine protein kinase. (569 aa)
	HDAC2	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (469 aa)
	ATF6B	Activating transcription factor 6 beta. (707 aa)
	GRIN2B	Glutamate ionotropic receptor NMDA type subunit 2B. (1550 aa)
	SIRT1	Sirtuin 1. (557 aa)
	CALM2	Calmodulin 2; Belongs to the calmodulin family. (149 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (577 aa)
	DRD1	Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (446 aa)
	ARC	Activity regulated cytoskeleton associated protein. (396 aa)
	CAMK2B	Calcium/calmodulin dependent protein kinase II beta. (610 aa)
	DDC	Dopa decarboxylase. (480 aa)
	CACNA1C	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1479 aa)
	M3Z2Z7_MUSPF	Uncharacterized protein. (204 aa)
	PPP1CB	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
	CACNA1D	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2217 aa)
	M3YZ57_MUSPF	Uncharacterized protein. (168 aa)
	STX1A	Syntaxin 1A; Belongs to the syntaxin family. (259 aa)
	HDAC1	Histone deacetylase 1. (482 aa)
	GRIN1	Glutamate ionotropic receptor NMDA type subunit 1. (959 aa)
	PPP1R1B	Protein phosphatase 1 regulatory inhibitor subunit 1B. (206 aa)
	GRIN2A	Glutamate ionotropic receptor NMDA type subunit 2A; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1307 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (688 aa)
	GRIN2C	Glutamate ionotropic receptor NMDA type subunit 2C. (1109 aa)
	CALML4	Calmodulin like 4. (153 aa)
	ATF2	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
	CAMK2A	Calcium/calmodulin dependent protein kinase II alpha. (679 aa)
	ARSI	Arylsulfatase family member I. (575 aa)
	GRIA1	Glutamate ionotropic receptor AMPA type subunit 1. (906 aa)
	M3YPM9_MUSPF	BZIP domain-containing protein. (351 aa)
	MAOB	Amine oxidase. (521 aa)
	M3YMK5_MUSPF	Protein kinase domain-containing protein. (185 aa)
	M3YMK1_MUSPF	Protein kinase domain-containing protein. (105 aa)
	MAOA	Amine oxidase. (518 aa)
	CREB1	cAMP responsive element binding protein 1. (341 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY5	CALM1	ENSMPUP00000004470	ENSMPUP00000008029	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin 1; Belongs to the calmodulin family.	0.797
ADCY5	CALM2	ENSMPUP00000004470	ENSMPUP00000011969	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin 2; Belongs to the calmodulin family.	0.797
ADCY5	CALM3	ENSMPUP00000004470	ENSMPUP00000005223	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin 3; Belongs to the calmodulin family.	0.797
ADCY5	CALML4	ENSMPUP00000004470	ENSMPUP00000000268	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 4.	0.881
ADCY5	CALML5	ENSMPUP00000004470	ENSMPUP00000019445	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 5.	0.882
ADCY5	CALML6	ENSMPUP00000004470	ENSMPUP00000007945	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 6.	0.853
ADCY5	CAMK2A	ENSMPUP00000004470	ENSMPUP00000013741	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calcium/calmodulin dependent protein kinase II alpha.	0.841
ADCY5	CAMK2B	ENSMPUP00000004470	ENSMPUP00000018087	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calcium/calmodulin dependent protein kinase II beta.	0.840
ADCY5	CAMK2G	ENSMPUP00000004470	ENSMPUP00000003346	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calcium/calmodulin dependent protein kinase II gamma.	0.843
ADCY5	M3Y692_MUSPF	ENSMPUP00000004470	ENSMPUP00000006843	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.999
ADCY5	M3YA76_MUSPF	ENSMPUP00000004470	ENSMPUP00000008233	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase domain-containing protein.	0.861
ADCY5	M3YMK1_MUSPF	ENSMPUP00000004470	ENSMPUP00000012558	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase domain-containing protein.	0.833
ADCY5	M3YMK5_MUSPF	ENSMPUP00000004470	ENSMPUP00000012562	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase domain-containing protein.	0.833
ADCY5	M3Z785_MUSPF	ENSMPUP00000004470	ENSMPUP00000019448	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein; Belongs to the calmodulin family.	0.797
ADCY5	PRKACA	ENSMPUP00000004470	ENSMPUP00000003045	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.944
ADCY5	PRKACB	ENSMPUP00000004470	ENSMPUP00000005718	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.944
ADCY5	PRKCA	ENSMPUP00000004470	ENSMPUP00000014555	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.930
ADCY5	PRKCB	ENSMPUP00000004470	ENSMPUP00000012100	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.866
ADCY5	PRKCG	ENSMPUP00000004470	ENSMPUP00000010076	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Non-specific serine/threonine protein kinase.	0.866
ARC	GRIN1	ENSMPUP00000019070	ENSMPUP00000014890	Activity regulated cytoskeleton associated protein.	Glutamate ionotropic receptor NMDA type subunit 1.	0.407