STRINGSTRING
C7orf31 C7orf31 CLK1 CLK1 CASP8 CASP8 M3XMK0_MUSPF M3XMK0_MUSPF M3XNB0_MUSPF M3XNB0_MUSPF M3XND8_MUSPF M3XND8_MUSPF CLK4 CLK4 ARF1 ARF1 M3XPX4_MUSPF M3XPX4_MUSPF SEC22B SEC22B M3XR35_MUSPF M3XR35_MUSPF TLR4 TLR4 CASP7 CASP7 BNIP3 BNIP3 MYD88 MYD88 M3XUU3_MUSPF M3XUU3_MUSPF IL12A IL12A M3XVN3_MUSPF M3XVN3_MUSPF M3XVS8_MUSPF M3XVS8_MUSPF IL18 IL18 M3XXI5_MUSPF M3XXI5_MUSPF M3XYC4_MUSPF M3XYC4_MUSPF M3XYR2_MUSPF M3XYR2_MUSPF EEF1A1 EEF1A1 SAR1A SAR1A VCP VCP GUF1 GUF1 NLRC4 NLRC4 HSF4 HSF4 CLK2 CLK2 M3Y362_MUSPF M3Y362_MUSPF RAB1A RAB1A HSF1 HSF1 M3Y6H4_MUSPF M3Y6H4_MUSPF C3 C3 M3Y8D0_MUSPF M3Y8D0_MUSPF M3Y8V3_MUSPF M3Y8V3_MUSPF M3YA06_MUSPF M3YA06_MUSPF EEF1A2 EEF1A2 CD14 CD14 CXCL8 CXCL8 NFKB1 NFKB1 M3YDD5_MUSPF M3YDD5_MUSPF M3YEG3_MUSPF M3YEG3_MUSPF M3YEH1_MUSPF M3YEH1_MUSPF SAR1B SAR1B ITGB2 ITGB2 M3YH30_MUSPF M3YH30_MUSPF IL1B IL1B M3YHB9_MUSPF M3YHB9_MUSPF METRNL METRNL M3YHK0_MUSPF M3YHK0_MUSPF CASP3 CASP3 M3YI72_MUSPF M3YI72_MUSPF RAB1B RAB1B ITGAM ITGAM TNF TNF PYCARD PYCARD APAF1 APAF1 RELA RELA M3YK66_MUSPF M3YK66_MUSPF M3YLQ8_MUSPF M3YLQ8_MUSPF M3YM35_MUSPF M3YM35_MUSPF IL12B IL12B IL6 IL6 EEF1G EEF1G HSF2 HSF2 HBS1L HBS1L M3YV51_MUSPF M3YV51_MUSPF OTUD3 OTUD3 NFKBIA NFKBIA CASP9 CASP9 NFKB2 NFKB2 M3Z002_MUSPF M3Z002_MUSPF CLK3 CLK3 BCL2L13 BCL2L13 EFCAB10 EFCAB10 HSPA1L HSPA1L TLR5 TLR5 M3Z4Y0_MUSPF M3Z4Y0_MUSPF TLR2 TLR2 HSPA8 HSPA8 HSPA2 HSPA2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
C7orf31Chromosome 7 open reading frame 31. (589 aa)
CLK1CDC like kinase 1; Belongs to the protein kinase superfamily. (484 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (484 aa)
M3XMK0_MUSPFUncharacterized protein. (428 aa)
M3XNB0_MUSPFTr-type G domain-containing protein. (449 aa)
M3XND8_MUSPFUncharacterized protein. (402 aa)
CLK4CDC like kinase 4; Belongs to the protein kinase superfamily. (481 aa)
ARF1ADP ribosylation factor 1; Belongs to the small GTPase superfamily. Arf family. (181 aa)
M3XPX4_MUSPFUncharacterized protein. (367 aa)
SEC22BSEC22 homolog B, vesicle trafficking protein (gene/pseudogene); Belongs to the synaptobrevin family. (215 aa)
M3XR35_MUSPFTr-type G domain-containing protein. (460 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
CASP7Caspase 7; Belongs to the peptidase C14A family. (301 aa)
BNIP3BCL2 interacting protein 3. (190 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
M3XUU3_MUSPFTr-type G domain-containing protein. (447 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
M3XVN3_MUSPFUncharacterized protein; Belongs to the TCP-1 chaperonin family. (357 aa)
M3XVS8_MUSPFCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
M3XXI5_MUSPFElongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (392 aa)
M3XYC4_MUSPFUncharacterized protein. (314 aa)
M3XYR2_MUSPFTr-type G domain-containing protein. (452 aa)
EEF1A1Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (398 aa)
SAR1ASecretion associated Ras related GTPase 1A; Belongs to the small GTPase superfamily. SAR1 family. (198 aa)
VCPValosin containing protein; Belongs to the AAA ATPase family. (806 aa)
GUF1Translation factor GUF1, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. (669 aa)
NLRC4NLR family CARD domain containing 4. (1007 aa)
HSF4Heat shock transcription factor 4. (492 aa)
CLK2Secretory carrier-associated membrane protein. (763 aa)
M3Y362_MUSPFUncharacterized protein; Belongs to the heat shock protein 70 family. (646 aa)
RAB1ARAB1A, member RAS oncogene family. (251 aa)
HSF1Heat shock transcription factor 1. (555 aa)
M3Y6H4_MUSPFUncharacterized protein. (452 aa)
C3Complement C3. (1668 aa)
M3Y8D0_MUSPFUncharacterized protein; Belongs to the heat shock protein 70 family. (617 aa)
M3Y8V3_MUSPFUncharacterized protein; Belongs to the chaperonin (HSP60) family. (575 aa)
M3YA06_MUSPFUncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (181 aa)
EEF1A2Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (422 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (371 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
NFKB1Nuclear factor kappa B subunit 1. (971 aa)
M3YDD5_MUSPFUncharacterized protein; Belongs to the chaperonin (HSP60) family. (494 aa)
M3YEG3_MUSPFUncharacterized protein. (619 aa)
M3YEH1_MUSPFUncharacterized protein. (316 aa)
SAR1BSecretion associated Ras related GTPase 1B; Belongs to the small GTPase superfamily. SAR1 family. (198 aa)
ITGB2Integrin beta. (782 aa)
M3YH30_MUSPFUncharacterized protein. (419 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (168 aa)
M3YHB9_MUSPFUncharacterized protein; Belongs to the heat shock protein 70 family. (642 aa)
METRNLMeteorin like, glial cell differentiation regulator. (254 aa)
M3YHK0_MUSPFUncharacterized protein. (183 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
M3YI72_MUSPFUncharacterized protein. (361 aa)
RAB1BRAB1B, member RAS oncoprotein family. (210 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1053 aa)
TNFTumor necrosis factor alpha; Belongs to the tumor necrosis factor family. (233 aa)
PYCARDPYD and CARD domain containing. (193 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1250 aa)
RELARELA proto-oncogene, NF-kB subunit. (511 aa)
M3YK66_MUSPFGTP_EFTU_D3 domain-containing protein. (312 aa)
M3YLQ8_MUSPFUncharacterized protein; Belongs to the chaperonin (HSP60) family. (495 aa)
M3YM35_MUSPFUncharacterized protein; Belongs to the heat shock protein 70 family. (567 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (331 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (210 aa)
EEF1GEukaryotic translation elongation factor 1 gamma. (437 aa)
HSF2Heat shock transcription factor 2. (651 aa)
HBS1LHBS1 like translational GTPase. (685 aa)
M3YV51_MUSPFUncharacterized protein. (147 aa)
OTUD3OTU deubiquitinase 3. (398 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (451 aa)
NFKB2Nuclear factor kappa B subunit 2. (900 aa)
M3Z002_MUSPFUncharacterized protein. (437 aa)
CLK3CDC like kinase 3; Belongs to the protein kinase superfamily. (490 aa)
BCL2L13BCL2 like 13. (464 aa)
EFCAB10EF-hand calcium binding domain 10. (159 aa)
HSPA1LHeat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family. (641 aa)
TLR5Toll like receptor 5; Belongs to the Toll-like receptor family. (858 aa)
M3Z4Y0_MUSPFCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
TLR2Toll like receptor 2; Belongs to the Toll-like receptor family. (785 aa)
HSPA8Uncharacterized protein; Belongs to the heat shock protein 70 family. (643 aa)
HSPA2Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (635 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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