STRINGSTRING
M3Y650_MUSPF M3Y650_MUSPF MAP2K3 MAP2K3 VAV3 VAV3 LPXN LPXN IRAK4 IRAK4 MAP2K1 MAP2K1 MAPK9 MAPK9 PTK2B PTK2B M3XR07_MUSPF M3XR07_MUSPF M3XRJ3_MUSPF M3XRJ3_MUSPF TLR4 TLR4 M3XRS9_MUSPF M3XRS9_MUSPF M3XRT3_MUSPF M3XRT3_MUSPF PTK2 PTK2 AKT1 AKT1 MAPK11 MAPK11 MAPK10 MAPK10 ITGA4 ITGA4 MAPK12 MAPK12 M3XTE0_MUSPF M3XTE0_MUSPF IRF3 IRF3 DOCK1 DOCK1 MYD88 MYD88 PKN1 PKN1 PXN PXN MAPK1 MAPK1 DOCK5 DOCK5 RPS6KA3 RPS6KA3 CRKL CRKL GNA11 GNA11 MAP2K4 MAP2K4 IL18 IL18 PIP5K1A PIP5K1A MAPK14 MAPK14 GIT2 GIT2 PIP5K1C PIP5K1C MAPK13 MAPK13 M3XYN0_MUSPF M3XYN0_MUSPF SKAP2 SKAP2 M3Y027_MUSPF M3Y027_MUSPF PKN2 PKN2 WIPF3 WIPF3 M3Y130_MUSPF M3Y130_MUSPF NLRC4 NLRC4 TICAM1 TICAM1 ROCK1 ROCK1 ARHGEF12 ARHGEF12 ITGA5 ITGA5 ARHGEF28 ARHGEF28 JUN JUN ARF6 ARF6 RHOG RHOG IFNB1 IFNB1 TAB2 TAB2 SRC SRC AKT2 AKT2 PLCG1 PLCG1 ELMO2 ELMO2 NFATC2 NFATC2 TBK1 TBK1 IL2 IL2 PIK3CA PIK3CA CHUK CHUK CD4 CD4 NFATC1 NFATC1 ACTB ACTB RAC1 RAC1 NFKBIA NFKBIA ACTL8 ACTL8 LIMK1 LIMK1 M3YX33_MUSPF M3YX33_MUSPF M3YWQ4_MUSPF M3YWQ4_MUSPF AKT3 AKT3 M3YWA8_MUSPF M3YWA8_MUSPF RPS6KA1 RPS6KA1 WASF2 WASF2 LCK LCK MEFV MEFV WIPF2 WIPF2 CCL2 CCL2 FYB1 FYB1 PIK3R1 PIK3R1 MAP2K6 MAP2K6 M3YRA3_MUSPF M3YRA3_MUSPF RHOA RHOA CRK CRK WAS WAS IL6 IL6 ROCK2 ROCK2 TAB1 TAB1 M3YNJ8_MUSPF M3YNJ8_MUSPF LCP2 LCP2 LAT LAT IKBKB IKBKB RAC2 RAC2 MAPK3 MAPK3 GNAQ GNAQ NLRP10 NLRP10 M3YLR8_MUSPF M3YLR8_MUSPF NLRP3 NLRP3 VAV2 VAV2 BAIAP2 BAIAP2 TRAF6 TRAF6 RELA RELA ACTG1 ACTG1 PYCARD PYCARD TNF TNF ZAP70 ZAP70 RAC3 RAC3 TRAF2 TRAF2 IL1B IL1B ACTR3 ACTR3 ARHGEF7 ARHGEF7 M3YF44_MUSPF M3YF44_MUSPF IL10 IL10 BCAR1 BCAR1 IKBKG IKBKG PIP5K1B PIP5K1B NFKB1 NFKB1 M3YDB4_MUSPF M3YDB4_MUSPF CD8B CD8B CD8A CD8A CXCL8 CXCL8 FOS FOS MAPK8 MAPK8 PIK3CB PIK3CB MAP3K7 MAP3K7 IRAK1 IRAK1 M3YB13_MUSPF M3YB13_MUSPF M3YAZ8_MUSPF M3YAZ8_MUSPF M3YAY8_MUSPF M3YAY8_MUSPF TRBV25-1 TRBV25-1 M3YAV2_MUSPF M3YAV2_MUSPF M3YAT2_MUSPF M3YAT2_MUSPF GSK3B GSK3B MAP2K7 MAP2K7 M3Y9A1_MUSPF M3Y9A1_MUSPF ELMO1 ELMO1 FN1 FN1 TRAV18 TRAV18 M3Y7K5_MUSPF M3Y7K5_MUSPF M3Y7D3_MUSPF M3Y7D3_MUSPF ARHGEF1 ARHGEF1 VAV1 VAV1 NFATC3 NFATC3 M3Y645_MUSPF M3Y645_MUSPF WASL WASL RPS6KA2 RPS6KA2 RPS6KA6 RPS6KA6 PIK3CD PIK3CD ACTR2 ACTR2 ITGB1 ITGB1 M3Y3E0_MUSPF M3Y3E0_MUSPF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
M3Y650_MUSPFIg-like domain-containing protein. (142 aa)
MAP2K3Mitogen-activated protein kinase kinase 3. (396 aa)
VAV3Vav guanine nucleotide exchange factor 3. (847 aa)
LPXNLeupaxin; Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin- induced tyrosine phosphorylation of paxillin (PXN). (414 aa)
IRAK4Interleukin-1 receptor-associated kinase 4. (460 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
MAPK9Mitogen-activated protein kinase. (398 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
M3XR07_MUSPFUncharacterized protein; Belongs to the actin family. (362 aa)
M3XRJ3_MUSPFUncharacterized protein. (182 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
M3XRS9_MUSPFIg-like domain-containing protein. (117 aa)
M3XRT3_MUSPFIg-like domain-containing protein. (118 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1096 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
MAPK11Mitogen-activated protein kinase. (434 aa)
MAPK10Mitogen-activated protein kinase. (384 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1033 aa)
MAPK12Mitogen-activated protein kinase. (287 aa)
M3XTE0_MUSPFUncharacterized protein; Belongs to the actin family. (348 aa)
IRF3Interferon regulatory factor 3. (421 aa)
DOCK1Dedicator of cytokinesis 1; Belongs to the DOCK family. (1813 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
PKN1Protein kinase N1. (950 aa)
PXNPaxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (590 aa)
MAPK1Mitogen-activated protein kinase. (333 aa)
DOCK5Dedicator of cytokinesis 5; Belongs to the DOCK family. (1869 aa)
RPS6KA3Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (741 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
GNA11G protein subunit alpha 11. (334 aa)
MAP2K4Mitogen-activated protein kinase kinase 4. (281 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (565 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
GIT2GIT ArfGAP 2. (759 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (653 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
M3XYN0_MUSPFUncharacterized protein. (192 aa)
SKAP2Src kinase associated phosphoprotein 2. (359 aa)
M3Y027_MUSPFProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
PKN2Protein kinase N2. (983 aa)
WIPF3WAS/WASL interacting protein family member 3. (451 aa)
M3Y130_MUSPFUncharacterized protein. (200 aa)
NLRC4NLR family CARD domain containing 4. (1007 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (689 aa)
ROCK1Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1252 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1544 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1104 aa)
ARHGEF28Rho guanine nucleotide exchange factor 28. (1703 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
ARF6ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
RHOGRas homolog family member G. (191 aa)
IFNB1Interferon beta. (186 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
SRCTyrosine-protein kinase. (536 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
ELMO2Engulfment and cell motility 2. (720 aa)
NFATC2Nuclear factor of activated T cells 2. (912 aa)
TBK1TANK-binding kinase 1. (729 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (152 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
CD4CD4. (462 aa)
NFATC1Nuclear factor of activated T cells 1. (701 aa)
ACTBActin beta. (375 aa)
RAC1Rac family small GTPase 1. (167 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
ACTL8Actin like 8; Belongs to the actin family. (366 aa)
LIMK1LIM domain kinase 1. (626 aa)
M3YX33_MUSPFUncharacterized protein. (191 aa)
M3YWQ4_MUSPFUncharacterized protein; Belongs to the actin family. (338 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa)
M3YWA8_MUSPFUncharacterized protein. (726 aa)
RPS6KA1Ribosomal protein S6 kinase. (719 aa)
WASF2WASP family member 2. (498 aa)
LCKTyrosine-protein kinase. (509 aa)
MEFVMEFV innate immuity regulator, pyrin. (785 aa)
WIPF2WAS/WASL interacting protein family member 2. (440 aa)
CCL2C-C motif chemokine. (101 aa)
FYB1FYN binding protein 1. (838 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
M3YRA3_MUSPFWH2 domain-containing protein. (493 aa)
RHOARas homolog family member A. (193 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
WASWASP actin nucleation promoting factor. (501 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (210 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1389 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
M3YNJ8_MUSPFUncharacterized protein. (461 aa)
LCP2Lymphocyte cytosolic protein 2. (536 aa)
LATLinker for activation of T cells. (260 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
RAC2Rac family small GTPase 2. (192 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (399 aa)
GNAQG protein subunit alpha q. (301 aa)
NLRP10NLR family pyrin domain containing 10. (561 aa)
M3YLR8_MUSPFRHD domain-containing protein. (249 aa)
NLRP3NLR family pyrin domain containing 3. (1035 aa)
VAV2Vav guanine nucleotide exchange factor 2. (834 aa)
BAIAP2BAI1-associated protein 2. (500 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
RELARELA proto-oncogene, NF-kB subunit. (511 aa)
ACTG1Actin gamma 1. (375 aa)
PYCARDPYD and CARD domain containing. (193 aa)
TNFTumor necrosis factor alpha; Belongs to the tumor necrosis factor family. (233 aa)
ZAP70Tyrosine-protein kinase. (616 aa)
RAC3Rac family small GTPase 3. (160 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (569 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (168 aa)
ACTR3Actin related protein 3; Belongs to the actin family. (418 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7. (844 aa)
M3YF44_MUSPFIg-like domain-containing protein. (122 aa)
IL10Interleukin 10. (220 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (867 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (412 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (540 aa)
NFKB1Nuclear factor kappa B subunit 1. (971 aa)
M3YDB4_MUSPFUncharacterized protein; Belongs to the actin family. (409 aa)
CD8BIg-like domain-containing protein. (209 aa)
CD8ACD8a molecule. (242 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (446 aa)
MAPK8Mitogen-activated protein kinase. (397 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (696 aa)
M3YB13_MUSPFIg-like domain-containing protein. (159 aa)
M3YAZ8_MUSPFIg-like domain-containing protein. (158 aa)
M3YAY8_MUSPFIg-like domain-containing protein. (227 aa)
TRBV25-1T cell receptor beta variable 25-1. (125 aa)
M3YAV2_MUSPFIg-like domain-containing protein. (141 aa)
M3YAT2_MUSPFIg-like domain-containing protein. (186 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (420 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (461 aa)
M3Y9A1_MUSPFUncharacterized protein. (364 aa)
ELMO1Engulfment and cell motility 1. (727 aa)
FN1Fibronectin 1. (2387 aa)
TRAV18T cell receptor alpha variable 18. (159 aa)
M3Y7K5_MUSPFIg-like domain-containing protein. (163 aa)
M3Y7D3_MUSPFDUF1968 domain-containing protein. (157 aa)
ARHGEF1Rho guanine nucleotide exchange factor 1. (987 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
NFATC3Nuclear factor of activated T cells 3. (1037 aa)
M3Y645_MUSPFIg-like domain-containing protein. (167 aa)
WASLWASP like actin nucleation promoting factor. (505 aa)
RPS6KA2Ribosomal protein S6 kinase. (733 aa)
RPS6KA6Ribosomal protein S6 kinase. (794 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (394 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
M3Y3E0_MUSPFIg-like domain-containing protein. (121 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
Server load: low (34%) [HD]