STRINGSTRING
PTPN6 PTPN6 M3Z002_MUSPF M3Z002_MUSPF IFNG IFNG TGFB1 TGFB1 NFKBIB NFKBIB TAB2 TAB2 JUN JUN TLR2 TLR2 M3XMK0_MUSPF M3XMK0_MUSPF IRAK4 IRAK4 M3XNB0_MUSPF M3XNB0_MUSPF M3XND8_MUSPF M3XND8_MUSPF JAK1 JAK1 M3XPX4_MUSPF M3XPX4_MUSPF IFNGR2 IFNGR2 M3XQD9_MUSPF M3XQD9_MUSPF M3XR35_MUSPF M3XR35_MUSPF TLR4 TLR4 M3XRS9_MUSPF M3XRS9_MUSPF M3XRT3_MUSPF M3XRT3_MUSPF M3XS58_MUSPF M3XS58_MUSPF M3XS76_MUSPF M3XS76_MUSPF HLA-DMA HLA-DMA HLA-DOA HLA-DOA HLA-DPA1 HLA-DPA1 MAPK11 MAPK11 ITGA4 ITGA4 MAPK12 MAPK12 MYD88 MYD88 M3XUU3_MUSPF M3XUU3_MUSPF IL12A IL12A MAPK1 MAPK1 M3XWH1_MUSPF M3XWH1_MUSPF M3XXI5_MUSPF M3XXI5_MUSPF MAPK14 MAPK14 MAPK13 MAPK13 M3XYC4_MUSPF M3XYC4_MUSPF TGFB2 TGFB2 M3XYR2_MUSPF M3XYR2_MUSPF EEF1A1 EEF1A1 JAK2 JAK2 M3Y2L0_MUSPF M3Y2L0_MUSPF M3Y3E0_MUSPF M3Y3E0_MUSPF ITGB1 ITGB1 M3Y3I6_MUSPF M3Y3I6_MUSPF M3Y645_MUSPF M3Y645_MUSPF M3Y650_MUSPF M3Y650_MUSPF M3Y6H4_MUSPF M3Y6H4_MUSPF C3 C3 M3Y779_MUSPF M3Y779_MUSPF M3Y7C9_MUSPF M3Y7C9_MUSPF M3Y9A1_MUSPF M3Y9A1_MUSPF CYBA CYBA EEF1A2 EEF1A2 IRAK1 IRAK1 MAP3K7 MAP3K7 FOS FOS NFKB1 NFKB1 M3YDZ3_MUSPF M3YDZ3_MUSPF M3YE13_MUSPF M3YE13_MUSPF IL1A IL1A M3YEG3_MUSPF M3YEG3_MUSPF M3YEH1_MUSPF M3YEH1_MUSPF IL10 IL10 M3YF44_MUSPF M3YF44_MUSPF ITGB2 ITGB2 IL4 IL4 M3YH02_MUSPF M3YH02_MUSPF M3YH07_MUSPF M3YH07_MUSPF M3YH30_MUSPF M3YH30_MUSPF IL1B IL1B PTGS2 PTGS2 M3YI72_MUSPF M3YI72_MUSPF ITGAM ITGAM TNF TNF RELA RELA NCF2 NCF2 TRAF6 TRAF6 M3YK66_MUSPF M3YK66_MUSPF PRKCB PRKCB XK XK CYBB CYBB STAT1 STAT1 NCF4 NCF4 MAPK3 MAPK3 IL12B IL12B TAB1 TAB1 ELK1 ELK1 NOS2 NOS2 IFNGR1 IFNGR1 LOC101678178 LOC101678178 NOXA1 NOXA1 MARCKSL1 MARCKSL1 NCF1 NCF1 NFKBIA NFKBIA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (595 aa)
M3Z002_MUSPFUncharacterized protein. (437 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). (166 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
NFKBIBNFKB inhibitor beta. (354 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
TLR2Toll like receptor 2; Belongs to the Toll-like receptor family. (785 aa)
M3XMK0_MUSPFUncharacterized protein. (428 aa)
IRAK4Interleukin-1 receptor-associated kinase 4. (460 aa)
M3XNB0_MUSPFTr-type G domain-containing protein. (449 aa)
M3XND8_MUSPFUncharacterized protein. (402 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
M3XPX4_MUSPFUncharacterized protein. (367 aa)
IFNGR2Interferon gamma receptor 2. (341 aa)
M3XQD9_MUSPFIGv domain-containing protein. (115 aa)
M3XR35_MUSPFTr-type G domain-containing protein. (460 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
M3XRS9_MUSPFIg-like domain-containing protein. (117 aa)
M3XRT3_MUSPFIg-like domain-containing protein. (118 aa)
M3XS58_MUSPFIg-like domain-containing protein. (171 aa)
M3XS76_MUSPFIg-like domain-containing protein. (263 aa)
HLA-DMAMajor histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family. (261 aa)
HLA-DOAMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa)
HLA-DPA1Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (242 aa)
MAPK11Mitogen-activated protein kinase. (434 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1033 aa)
MAPK12Mitogen-activated protein kinase. (287 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
M3XUU3_MUSPFTr-type G domain-containing protein. (447 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
MAPK1Mitogen-activated protein kinase. (333 aa)
M3XWH1_MUSPFUncharacterized protein. (249 aa)
M3XXI5_MUSPFElongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (392 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
M3XYC4_MUSPFUncharacterized protein. (314 aa)
TGFB2Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] (414 aa)
M3XYR2_MUSPFTr-type G domain-containing protein. (452 aa)
EEF1A1Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (398 aa)
JAK2Tyrosine-protein kinase. (1130 aa)
M3Y2L0_MUSPFFc of IgG, high affinity Ia, receptor. (352 aa)
M3Y3E0_MUSPFIg-like domain-containing protein. (121 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
M3Y3I6_MUSPFIg-like domain-containing protein; Belongs to the MHC class II family. (255 aa)
M3Y645_MUSPFIg-like domain-containing protein. (167 aa)
M3Y650_MUSPFIg-like domain-containing protein. (142 aa)
M3Y6H4_MUSPFUncharacterized protein. (452 aa)
C3Complement C3. (1668 aa)
M3Y779_MUSPFIg-like domain-containing protein. (269 aa)
M3Y7C9_MUSPFIg-like domain-containing protein. (266 aa)
M3Y9A1_MUSPFUncharacterized protein. (364 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (194 aa)
EEF1A2Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (422 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (696 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (446 aa)
NFKB1Nuclear factor kappa B subunit 1. (971 aa)
M3YDZ3_MUSPFMHC_II_alpha domain-containing protein. (236 aa)
M3YE13_MUSPFIg-like domain-containing protein. (233 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (270 aa)
M3YEG3_MUSPFUncharacterized protein. (619 aa)
M3YEH1_MUSPFUncharacterized protein. (316 aa)
IL10Interleukin 10. (220 aa)
M3YF44_MUSPFIg-like domain-containing protein. (122 aa)
ITGB2Integrin beta. (782 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (132 aa)
M3YH02_MUSPFIg-like domain-containing protein; Belongs to the MHC class II family. (250 aa)
M3YH07_MUSPFIg-like domain-containing protein. (265 aa)
M3YH30_MUSPFUncharacterized protein. (419 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (168 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
M3YI72_MUSPFUncharacterized protein. (361 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1053 aa)
TNFTumor necrosis factor alpha; Belongs to the tumor necrosis factor family. (233 aa)
RELARELA proto-oncogene, NF-kB subunit. (511 aa)
NCF2Neutrophil cytosolic factor 2. (620 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
M3YK66_MUSPFGTP_EFTU_D3 domain-containing protein. (312 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (577 aa)
XKXK-related protein. (444 aa)
CYBBCytochrome b-245 beta chain. (568 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
NCF4Neutrophil cytosolic factor 4. (339 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (399 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (331 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
ELK1ETS transcription factor ELK1. (435 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1064 aa)
IFNGR1Interferon gamma receptor 1. (474 aa)
LOC101678178Ig-like domain-containing protein; Belongs to the MHC class II family. (196 aa)
NOXA1NADPH oxidase activator 1. (467 aa)
MARCKSL1MARCKS like 1. (199 aa)
NCF1Neutrophil cytosolic factor 1. (391 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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