STRINGSTRING
HBZ HBZ TLR4 TLR4 LRP1 LRP1 CD40LG CD40LG MYD88 MYD88 IL12A IL12A NID1 NID1 IL18 IL18 M3XX61_MUSPF M3XX61_MUSPF TGFB2 TGFB2 THBS4 THBS4 NID2 NID2 CD81 CD81 TSPAN32 TSPAN32 THBS3 THBS3 KLRB1 KLRB1 M3Y420_MUSPF M3Y420_MUSPF M3Y460_MUSPF M3Y460_MUSPF KLRF1 KLRF1 M3Y4B5_MUSPF M3Y4B5_MUSPF M3Y5G1_MUSPF M3Y5G1_MUSPF THBS2 THBS2 ICAM1 ICAM1 MET MET M3Y7D3_MUSPF M3Y7D3_MUSPF M3Y7K5_MUSPF M3Y7K5_MUSPF TRAV18 TRAV18 M3Y7P0_MUSPF M3Y7P0_MUSPF M3Y7P9_MUSPF M3Y7P9_MUSPF THBS1 THBS1 M3YAT2_MUSPF M3YAT2_MUSPF M3YAV2_MUSPF M3YAV2_MUSPF TRBV25-1 TRBV25-1 M3YAW1_MUSPF M3YAW1_MUSPF TRBV19 TRBV19 M3YAX3_MUSPF M3YAX3_MUSPF TRBV16 TRBV16 M3YAY8_MUSPF M3YAY8_MUSPF M3YAZ1_MUSPF M3YAZ1_MUSPF M3YAZ8_MUSPF M3YAZ8_MUSPF M3YB13_MUSPF M3YB13_MUSPF SDC2 SDC2 NGB NGB CXCL8 CXCL8 M3YEG3_MUSPF M3YEG3_MUSPF M3YEH1_MUSPF M3YEH1_MUSPF IL10 IL10 M3YFF9_MUSPF M3YFF9_MUSPF HBB HBB M3YFH4_MUSPF M3YFH4_MUSPF ITGB2 ITGB2 IL1B IL1B TNF TNF M3YJV8_MUSPF M3YJV8_MUSPF VCAM1 VCAM1 ITGAL ITGAL MB MB ACKR1 ACKR1 CYGB CYGB IL6 IL6 SDC1 SDC1 INCENP INCENP LRP1B LRP1B PECAM1 PECAM1 CCL2 CCL2 CSF3 CSF3 SELP SELP COMP COMP SELE SELE HBQ1 HBQ1 HBA_MUSPF HBA_MUSPF IFNG IFNG CD40 CD40 TGFB1 TGFB1 CD36 CD36 HGF HGF TLR2 TLR2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HBZHemoglobin subunit zeta; Belongs to the globin family. (142 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
LRP1LDL receptor related protein 1. (4544 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (260 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
NID1Nidogen 1. (1237 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
M3XX61_MUSPFUncharacterized protein. (753 aa)
TGFB2Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] (414 aa)
THBS4Thrombospondin 4. (964 aa)
NID2Nidogen 2. (1466 aa)
CD81Tetraspanin. (287 aa)
TSPAN32Tetraspanin 32; Belongs to the tetraspanin (TM4SF) family. (292 aa)
THBS3Thrombospondin 3. (956 aa)
KLRB1Killer cell lectin like receptor B1. (228 aa)
M3Y420_MUSPFC-type lectin domain-containing protein. (190 aa)
M3Y460_MUSPFC-type lectin domain-containing protein. (295 aa)
KLRF1Killer cell lectin like receptor F1. (234 aa)
M3Y4B5_MUSPFC-type lectin domain-containing protein. (309 aa)
M3Y5G1_MUSPFUncharacterized protein. (130 aa)
THBS2Thrombospondin 2. (1173 aa)
ICAM1Intercellular adhesion molecule 1. (589 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1540 aa)
M3Y7D3_MUSPFDUF1968 domain-containing protein. (157 aa)
M3Y7K5_MUSPFIg-like domain-containing protein. (163 aa)
TRAV18T cell receptor alpha variable 18. (159 aa)
M3Y7P0_MUSPFUncharacterized protein. (54 aa)
M3Y7P9_MUSPFIg-like domain-containing protein. (166 aa)
THBS1Thrombospondin 1. (1170 aa)
M3YAT2_MUSPFIg-like domain-containing protein. (186 aa)
M3YAV2_MUSPFIg-like domain-containing protein. (141 aa)
TRBV25-1T cell receptor beta variable 25-1. (125 aa)
M3YAW1_MUSPFIGv domain-containing protein. (129 aa)
TRBV19T cell receptor beta variable 19. (158 aa)
M3YAX3_MUSPFIg-like domain-containing protein. (160 aa)
TRBV16T cell receptor beta variable 16 (gene/pseudogene). (118 aa)
M3YAY8_MUSPFIg-like domain-containing protein. (227 aa)
M3YAZ1_MUSPFIg-like domain-containing protein. (221 aa)
M3YAZ8_MUSPFIg-like domain-containing protein. (158 aa)
M3YB13_MUSPFIg-like domain-containing protein. (159 aa)
SDC2Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (201 aa)
NGBNeuroglobin; Belongs to the globin family. (151 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
M3YEG3_MUSPFUncharacterized protein. (619 aa)
M3YEH1_MUSPFUncharacterized protein. (316 aa)
IL10Interleukin 10. (220 aa)
M3YFF9_MUSPFGLOBIN domain-containing protein; Belongs to the globin family. (149 aa)
HBBHemoglobin subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues. (147 aa)
M3YFH4_MUSPFGLOBIN domain-containing protein; Belongs to the globin family. (147 aa)
ITGB2Integrin beta. (782 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (168 aa)
TNFTumor necrosis factor alpha; Belongs to the tumor necrosis factor family. (233 aa)
M3YJV8_MUSPFUncharacterized protein. (1327 aa)
VCAM1Vascular cell adhesion molecule 1. (739 aa)
ITGALIntegrin subunit alpha L; Belongs to the integrin alpha chain family. (1166 aa)
MBMyoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. (160 aa)
ACKR1Atypical chemokine receptor 1 (Duffy blood group). (329 aa)
CYGBCytoglobin; Belongs to the globin family. (190 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (210 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (295 aa)
INCENPInner centromere protein. (890 aa)
LRP1BLDL receptor related protein 1B. (3815 aa)
PECAM1Platelet and endothelial cell adhesion molecule 1. (739 aa)
CCL2C-C motif chemokine. (101 aa)
CSF3Colony stimulating factor 3. (204 aa)
SELPSelectin P. (831 aa)
COMPCartilage oligomeric matrix protein. (756 aa)
SELESelectin E. (609 aa)
HBQ1Hemoglobin subunit theta 1; Belongs to the globin family. (162 aa)
HBA_MUSPFHemoglobin subunit alpha-1/2; Involved in oxygen transport from the lung to the various peripheral tissues; Belongs to the globin family. (143 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). (166 aa)
CD40CD40 molecule. (277 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
TLR2Toll like receptor 2; Belongs to the Toll-like receptor family. (785 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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