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COL4A2 COL4A2 M3YGL9_MUSPF M3YGL9_MUSPF ITGB2 ITGB2 SPECC1 SPECC1 LAMA4 LAMA4 PRKCG PRKCG M3YF44_MUSPF M3YF44_MUSPF IL10 IL10 LOC106004721 LOC106004721 NFKB1 NFKB1 CXCL8 CXCL8 PIK3CB PIK3CB CD14 CD14 PLCB2 PLCB2 M3Y9A1_MUSPF M3Y9A1_MUSPF LAMA5 LAMA5 FN1 FN1 ACTN1 ACTN1 C8B C8B C8A C8A ARG2 ARG2 DCLK2 DCLK2 M3Y692_MUSPF M3Y692_MUSPF M3Y650_MUSPF M3Y650_MUSPF M3Y645_MUSPF M3Y645_MUSPF M3Y5R6_MUSPF M3Y5R6_MUSPF PLCB4 PLCB4 PLCB1 PLCB1 PIK3CD PIK3CD M3Y3E0_MUSPF M3Y3E0_MUSPF LAMA3 LAMA3 PRKACB PRKACB CTSG CTSG LAMA1 LAMA1 PRDX2 PRDX2 GNAL GNAL TGFB2 TGFB2 COL4A5 COL4A5 COL4A6 COL4A6 GNA15 GNA15 GNA11 GNA11 VCL VCL PRKACA PRKACA LAMB3 LAMB3 IL12A IL12A SPECC1L SPECC1L PTK2 PTK2 M3XRT3_MUSPF M3XRT3_MUSPF M3XRS9_MUSPF M3XRS9_MUSPF TLR4 TLR4 COL1A2 COL1A2 MFF MFF COL4A3 COL4A3 M3XQD9_MUSPF M3XQD9_MUSPF COL4A4 COL4A4 RAB5B RAB5B SERPINB6 SERPINB6 SERPINB9 SERPINB9 SMTNL1 SMTNL1 RAB17 RAB17 M3YNJ8_MUSPF M3YNJ8_MUSPF RAB5A RAB5A IL12B IL12B IL6 IL6 LAMB2 LAMB2 NOS2 NOS2 LAMA2 LAMA2 ARG1 ARG1 PRKCA PRKCA PIK3R1 PIK3R1 C9 C9 COL1A1 COL1A1 M3YWA8_MUSPF M3YWA8_MUSPF HSPB1 HSPB1 SERPINB13 SERPINB13 SERPINB3 SERPINB3 SERPINB10 SERPINB10 SERPINB8 SERPINB8 PIK3CA PIK3CA RAB7A RAB7A IFNG IFNG TGFB1 TGFB1 ACTN4 ACTN4 ADCY1 ADCY1 LAMB4 LAMB4 LAMB1 LAMB1 TLR2 TLR2 M3Z654_MUSPF M3Z654_MUSPF LAMC2 LAMC2 RELA RELA RAB7B RAB7B PRKCB PRKCB IL1R2 IL1R2 IL1R1 IL1R1 COL3A1 COL3A1 GNA14 GNA14 GNAQ GNAQ LAMC3 LAMC3 CD1D CD1D M3YMZ2_MUSPF M3YMZ2_MUSPF M3YMZ5_MUSPF M3YMZ5_MUSPF LOC101690640 LOC101690640 LOC101689902 LOC101689902 M3YN29_MUSPF M3YN29_MUSPF M3YN32_MUSPF M3YN32_MUSPF M3YN36_MUSPF M3YN36_MUSPF CD1E CD1E SMTN SMTN LAMC1 LAMC1 PLCB3 PLCB3 CSF2 CSF2 TNF TNF ITGAM ITGAM SMTNL2 SMTNL2 COL4A1 COL4A1 CASP3 CASP3 C8G C8G IL1B IL1B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
COL4A2Collagen type IV alpha 2 chain. (1718 aa)
M3YGL9_MUSPFUncharacterized protein. (216 aa)
ITGB2Integrin beta. (782 aa)
SPECC1Sperm antigen with calponin homology and coiled-coil domains 1. (1059 aa)
LAMA4Laminin subunit alpha 4. (1931 aa)
PRKCGNon-specific serine/threonine protein kinase. (569 aa)
M3YF44_MUSPFIg-like domain-containing protein. (122 aa)
IL10Interleukin 10. (220 aa)
LOC106004721Uncharacterized protein. (146 aa)
NFKB1Nuclear factor kappa B subunit 1. (971 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (371 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1187 aa)
M3Y9A1_MUSPFUncharacterized protein. (364 aa)
LAMA5Laminin subunit alpha 5. (3008 aa)
FN1Fibronectin 1. (2387 aa)
ACTN1Actinin alpha 1. (914 aa)
C8BComplement C8 beta chain. (590 aa)
C8AComplement C8 alpha chain. (589 aa)
ARG2Arginase. (354 aa)
DCLK2Doublecortin like kinase 2. (699 aa)
M3Y692_MUSPFUncharacterized protein. (362 aa)
M3Y650_MUSPFIg-like domain-containing protein. (142 aa)
M3Y645_MUSPFIg-like domain-containing protein. (167 aa)
M3Y5R6_MUSPFUncharacterized protein. (2665 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1096 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
M3Y3E0_MUSPFIg-like domain-containing protein. (121 aa)
LAMA3Laminin subunit alpha 3. (3330 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
CTSGCathepsin G; Belongs to the peptidase S1 family. (300 aa)
LAMA1Laminin subunit alpha 1. (3086 aa)
PRDX2Peroxiredoxin 2. (199 aa)
GNALG protein subunit alpha L. (380 aa)
TGFB2Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] (414 aa)
COL4A5Collagen type IV alpha 5 chain. (1691 aa)
COL4A6Collagen type IV alpha 6 chain. (1501 aa)
GNA15G protein subunit alpha 15. (374 aa)
GNA11G protein subunit alpha 11. (334 aa)
VCLVinculin. (1134 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
LAMB3Laminin subunit beta 3. (1174 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
SPECC1LCalponin-homology (CH) domain-containing protein. (1118 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1096 aa)
M3XRT3_MUSPFIg-like domain-containing protein. (118 aa)
M3XRS9_MUSPFIg-like domain-containing protein. (117 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
COL1A2Collagen type I alpha 2 chain. (1367 aa)
MFFMitochondrial fission factor. (353 aa)
COL4A3Collagen type IV alpha 3 chain. (1669 aa)
M3XQD9_MUSPFIGv domain-containing protein. (115 aa)
COL4A4Collagen type IV alpha 4 chain. (1693 aa)
RAB5BRAB5B, member RAS oncogene family. (244 aa)
SERPINB6Serpin peptidase inhibitor, clade B, member 8; Belongs to the serpin family. (377 aa)
SERPINB9Serpin peptidase inhibitor, clade B, member 9; Belongs to the serpin family. (375 aa)
SMTNL1Smoothelin like 1. (454 aa)
RAB17RAB17, member RAS oncogene family. (225 aa)
M3YNJ8_MUSPFUncharacterized protein. (461 aa)
RAB5ARAB5A, member RAS oncogene family. (215 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (331 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (210 aa)
LAMB2Laminin subunit beta 2. (1801 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1064 aa)
LAMA2Laminin subunit alpha 2. (3137 aa)
ARG1Arginase. (322 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (688 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
C9Complement C9. (552 aa)
COL1A1Collagen type I alpha 1 chain. (1460 aa)
M3YWA8_MUSPFUncharacterized protein. (726 aa)
HSPB1Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (207 aa)
SERPINB13Serpin family B member 13; Belongs to the serpin family. (390 aa)
SERPINB3SERPIN domain-containing protein; Belongs to the serpin family. (398 aa)
SERPINB10Serpin family B member 10; Belongs to the serpin family. (430 aa)
SERPINB8Serpin family B member 8; Belongs to the serpin family. (374 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
RAB7ARAB7A, member RAS oncogene family. (207 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). (166 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
ACTN4Actinin alpha 4. (882 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1130 aa)
LAMB4Laminin subunit beta 4. (1791 aa)
LAMB1Laminin subunit beta 1. (1786 aa)
TLR2Toll like receptor 2; Belongs to the Toll-like receptor family. (785 aa)
M3Z654_MUSPFThioredoxin domain-containing protein. (200 aa)
LAMC2Laminin subunit gamma 2. (1191 aa)
RELARELA proto-oncogene, NF-kB subunit. (511 aa)
RAB7BRAB7B, member RAS oncogene family. (200 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (577 aa)
IL1R2Interleukin 1 receptor type 2. (414 aa)
IL1R1Interleukin 1 receptor type 1. (573 aa)
COL3A1Collagen type III alpha 1 chain. (1466 aa)
GNA14G protein subunit alpha 14. (355 aa)
GNAQG protein subunit alpha q. (301 aa)
LAMC3Laminin subunit gamma 3. (1516 aa)
CD1DCD1d molecule. (286 aa)
M3YMZ2_MUSPFMHC_I-like_Ag-recog domain-containing protein. (130 aa)
M3YMZ5_MUSPFMHC_I-like_Ag-recog domain-containing protein. (234 aa)
LOC101690640Ig-like domain-containing protein. (340 aa)
LOC101689902Ig-like domain-containing protein. (339 aa)
M3YN29_MUSPFIg-like domain-containing protein. (340 aa)
M3YN32_MUSPFIg-like domain-containing protein. (357 aa)
M3YN36_MUSPFMHC_I-like_Ag-recog domain-containing protein. (245 aa)
CD1ECD1e molecule. (395 aa)
SMTNSmoothelin. (916 aa)
LAMC1Laminin subunit gamma 1. (1573 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1233 aa)
CSF2Colony stimulating factor 2. (148 aa)
TNFTumor necrosis factor alpha; Belongs to the tumor necrosis factor family. (233 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1053 aa)
SMTNL2Smoothelin like 2. (449 aa)
COL4A1Collagen type IV alpha 1 chain. (1674 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
C8GComplement C8 gamma chain; Belongs to the calycin superfamily. Lipocalin family. (212 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (168 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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