STRINGSTRING
CASP8 CASP8 IRAK4 IRAK4 CD28 CD28 IFIH1 IFIH1 MAPK9 MAPK9 JAK1 JAK1 CDK2 CDK2 EIF3H EIF3H RACK1 RACK1 MSN MSN M3XQ69_MUSPF M3XQ69_MUSPF IFNAR1 IFNAR1 STAT2 STAT2 TLR4 TLR4 CDK4 CDK4 AKT1 AKT1 MAPK10 MAPK10 BAK1 BAK1 IRF3 IRF3 OAS1 OAS1 OAS3 OAS3 OAS2 OAS2 TLR7 TLR7 TRAF3 TRAF3 MYD88 MYD88 IL12A IL12A M3XUZ6_MUSPF M3XUZ6_MUSPF M3XVS8_MUSPF M3XVS8_MUSPF BAX BAX M3XWH7_MUSPF M3XWH7_MUSPF DDX58 DDX58 M3XZ95_MUSPF M3XZ95_MUSPF C7orf31 C7orf31 CD3E CD3E CD3D CD3D CD3G CD3G CCND1 CCND1 M3XZW3_MUSPF M3XZW3_MUSPF FADD FADD CSNK2A2 CSNK2A2 M3Y0R3_MUSPF M3Y0R3_MUSPF TRADD TRADD M3Y362_MUSPF M3Y362_MUSPF IRF9 IRF9 LIMCH1 LIMCH1 PIK3CD PIK3CD FAS FAS TYK2 TYK2 EIF2S1 EIF2S1 ADAR ADAR M3Y7D3_MUSPF M3Y7D3_MUSPF M3Y7K5_MUSPF M3Y7K5_MUSPF TRAV18 TRAV18 TP73 TP73 M3Y8D0_MUSPF M3Y8D0_MUSPF CCNE1 CCNE1 M3Y9Q7_MUSPF M3Y9Q7_MUSPF CLEC4G CLEC4G EIF2AK4 EIF2AK4 CDK6 CDK6 GSK3B GSK3B M3YAT2_MUSPF M3YAT2_MUSPF M3YAV2_MUSPF M3YAV2_MUSPF TRBV25-1 TRBV25-1 M3YAY8_MUSPF M3YAY8_MUSPF M3YAZ8_MUSPF M3YAZ8_MUSPF M3YB13_MUSPF M3YB13_MUSPF MAVS MAVS MX2 MX2 MX1 MX1 CCNE2 CCNE2 IRF7 IRF7 TP53 TP53 IRAK1 IRAK1 M3YCE7_MUSPF M3YCE7_MUSPF MAP3K7 MAP3K7 PIK3CB PIK3CB MAPK8 MAPK8 FOS FOS M3YD44_MUSPF M3YD44_MUSPF EIF2AK3 EIF2AK3 NFKB1 NFKB1 IL1A IL1A IKBKG IKBKG CBLB CBLB EIF2AK2 EIF2AK2 STAT3 STAT3 STAT5A STAT5A STAT5B STAT5B IL1B IL1B M3YHB9_MUSPF M3YHB9_MUSPF CASP3 CASP3 M3YI82_MUSPF M3YI82_MUSPF APAF1 APAF1 RELA RELA M3YJV8_MUSPF M3YJV8_MUSPF M3YK20_MUSPF M3YK20_MUSPF TRAF6 TRAF6 IKBKE IKBKE M3YM35_MUSPF M3YM35_MUSPF STAT1 STAT1 IL2RB IL2RB IKBKB IKBKB BAD BAD M3YNJ8_MUSPF M3YNJ8_MUSPF PPP1R14B PPP1R14B IL12B IL12B CCND3 CCND3 IL6 IL6 M3YRT8_MUSPF M3YRT8_MUSPF PIK3R1 PIK3R1 TNFAIP3 TNFAIP3 FASLG FASLG M3YWA8_MUSPF M3YWA8_MUSPF AKT3 AKT3 JAK3 JAK3 M3YX15_MUSPF M3YX15_MUSPF M3YX17_MUSPF M3YX17_MUSPF NFKBIA NFKBIA CASP9 CASP9 IL2RA IL2RA BCL2 BCL2 EIF2AK1 EIF2AK1 CHUK CHUK PIK3CA PIK3CA IL2 IL2 TBK1 TBK1 AKT2 AKT2 NFKBIB NFKBIB BCL2L1 BCL2L1 M3Z2K4_MUSPF M3Z2K4_MUSPF TAB2 TAB2 HSPA1L HSPA1L M3Z4Y0_MUSPF M3Z4Y0_MUSPF TLR2 TLR2 RAB9A RAB9A RAB9B RAB9B HSPA8 HSPA8 IFNG-2 IFNG-2 M3Z722_MUSPF M3Z722_MUSPF M3Z729_MUSPF M3Z729_MUSPF LOC101678496 LOC101678496 LOC101678795 LOC101678795 IFNB1 IFNB1 M3Z7C0_MUSPF M3Z7C0_MUSPF HSPA2 HSPA2 M3Z7V7_MUSPF M3Z7V7_MUSPF LOC101684074 LOC101684074 M3Z7W2_MUSPF M3Z7W2_MUSPF LOC101684365 LOC101684365 LOC101684645 LOC101684645 M3Z7X0_MUSPF M3Z7X0_MUSPF LOC101674940 LOC101674940 LOC101676633 LOC101676633 JUN JUN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CASP8Caspase 8; Belongs to the peptidase C14A family. (484 aa)
IRAK4Interleukin-1 receptor-associated kinase 4. (460 aa)
CD28CD28 molecule. (255 aa)
IFIH1Interferon induced with helicase C domain 1. (1027 aa)
MAPK9Mitogen-activated protein kinase. (398 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (334 aa)
EIF3HEukaryotic translation initiation factor 3 subunit H; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (352 aa)
RACK1WD_REPEATS_REGION domain-containing protein. (317 aa)
MSNMoesin. (577 aa)
M3XQ69_MUSPFUncharacterized protein. (517 aa)
IFNAR1Interferon alpha and beta receptor subunit 1. (560 aa)
STAT2Signal transducer and activator of transcription. (848 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (305 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
MAPK10Mitogen-activated protein kinase. (384 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
IRF3Interferon regulatory factor 3. (421 aa)
OAS12'-5'-oligoadenylate synthetase 1. (400 aa)
OAS32'-5'-oligoadenylate synthetase 3. (1230 aa)
OAS22'-5'-oligoadenylate synthetase 2. (685 aa)
TLR7Toll like receptor 7; Belongs to the Toll-like receptor family. (1083 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (569 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
M3XUZ6_MUSPFUncharacterized protein. (294 aa)
M3XVS8_MUSPFCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
M3XWH7_MUSPFIg-like domain-containing protein. (315 aa)
DDX58DExD/H-box helicase 58. (937 aa)
M3XZ95_MUSPFUncharacterized protein. (495 aa)
C7orf31Chromosome 7 open reading frame 31. (589 aa)
CD3ECD3 epsilon antigen. (186 aa)
CD3DCD3d molecule. (169 aa)
CD3GT-cell surface glycoprotein CD3 gamma chain. (180 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
M3XZW3_MUSPFFibronectin type-III domain-containing protein. (374 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (216 aa)
CSNK2A2Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. (326 aa)
M3Y0R3_MUSPFUncharacterized protein. (201 aa)
TRADDTNFRSF1A associated via death domain. (314 aa)
M3Y362_MUSPFUncharacterized protein; Belongs to the heat shock protein 70 family. (646 aa)
IRF9Interferon regulatory factor 9. (416 aa)
LIMCH1LIM and calponin homology domains 1. (1086 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
FASFas cell surface death receptor. (311 aa)
TYK2Tyrosine-protein kinase. (1182 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit alpha. (315 aa)
ADARAdenosine deaminase RNA specific. (1166 aa)
M3Y7D3_MUSPFDUF1968 domain-containing protein. (157 aa)
M3Y7K5_MUSPFIg-like domain-containing protein. (163 aa)
TRAV18T cell receptor alpha variable 18. (159 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (710 aa)
M3Y8D0_MUSPFUncharacterized protein; Belongs to the heat shock protein 70 family. (617 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (410 aa)
M3Y9Q7_MUSPFC-type lectin domain-containing protein. (237 aa)
CLEC4GC-type lectin domain family 4 member G. (317 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1657 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (420 aa)
M3YAT2_MUSPFIg-like domain-containing protein. (186 aa)
M3YAV2_MUSPFIg-like domain-containing protein. (141 aa)
TRBV25-1T cell receptor beta variable 25-1. (125 aa)
M3YAY8_MUSPFIg-like domain-containing protein. (227 aa)
M3YAZ8_MUSPFIg-like domain-containing protein. (158 aa)
M3YB13_MUSPFIg-like domain-containing protein. (159 aa)
MAVSMitochondrial antiviral signaling protein. (524 aa)
MX2MX dynamin like GTPase 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (717 aa)
MX1Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (670 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
IRF7Interferon regulatory factor 7. (473 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (375 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (696 aa)
M3YCE7_MUSPFUncharacterized protein. (124 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
MAPK8Mitogen-activated protein kinase. (397 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (446 aa)
M3YD44_MUSPFCyclin N-terminal domain-containing protein; Belongs to the cyclin family. (291 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1065 aa)
NFKB1Nuclear factor kappa B subunit 1. (971 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (270 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (412 aa)
CBLBCbl proto-oncogene B. (983 aa)
EIF2AK2Eukaryotic translation initiation factor 2 alpha kinase 2. (518 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
STAT5BSignal transducer and activator of transcription. (691 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (168 aa)
M3YHB9_MUSPFUncharacterized protein; Belongs to the heat shock protein 70 family. (642 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
M3YI82_MUSPFCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (215 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1250 aa)
RELARELA proto-oncogene, NF-kB subunit. (511 aa)
M3YJV8_MUSPFUncharacterized protein. (1327 aa)
M3YK20_MUSPFWD_REPEATS_REGION domain-containing protein. (237 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (719 aa)
M3YM35_MUSPFUncharacterized protein; Belongs to the heat shock protein 70 family. (567 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
IL2RBInterleukin 2 receptor subunit beta. (554 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
BADBCL2 associated agonist of cell death. (168 aa)
M3YNJ8_MUSPFUncharacterized protein. (461 aa)
PPP1R14BProtein phosphatase 1 regulatory inhibitor subunit 14B. (145 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (331 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (294 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (210 aa)
M3YRT8_MUSPFIg-like domain-containing protein. (339 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
TNFAIP3TNF alpha induced protein 3. (790 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (275 aa)
M3YWA8_MUSPFUncharacterized protein. (726 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa)
JAK3Tyrosine-protein kinase. (1107 aa)
M3YX15_MUSPFUncharacterized protein. (161 aa)
M3YX17_MUSPFUncharacterized protein. (158 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (451 aa)
IL2RAInterleukin 2 receptor subunit alpha. (267 aa)
BCL2BCL2 apoptosis regulator. (207 aa)
EIF2AK1Eukaryotic translation initiation factor 2 alpha kinase 1. (531 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (152 aa)
TBK1TANK-binding kinase 1. (729 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
NFKBIBNFKB inhibitor beta. (354 aa)
BCL2L1BCL2 like 1. (233 aa)
M3Z2K4_MUSPFProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (391 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
HSPA1LHeat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family. (641 aa)
M3Z4Y0_MUSPFCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
TLR2Toll like receptor 2; Belongs to the Toll-like receptor family. (785 aa)
RAB9ARAB9A, member RAS oncogene family. (201 aa)
RAB9BRAB9B, member RAS oncogene family. (201 aa)
HSPA8Uncharacterized protein; Belongs to the heat shock protein 70 family. (643 aa)
IFNG-2Uncharacterized protein. (187 aa)
M3Z722_MUSPFUncharacterized protein. (187 aa)
M3Z729_MUSPFUncharacterized protein. (187 aa)
LOC101678496Uncharacterized protein. (187 aa)
LOC101678795Uncharacterized protein. (182 aa)
IFNB1Interferon beta. (186 aa)
M3Z7C0_MUSPFCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (215 aa)
HSPA2Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (635 aa)
M3Z7V7_MUSPFUncharacterized protein. (187 aa)
LOC101684074Uncharacterized protein. (187 aa)
M3Z7W2_MUSPFUncharacterized protein. (187 aa)
LOC101684365Uncharacterized protein. (187 aa)
LOC101684645Uncharacterized protein. (187 aa)
M3Z7X0_MUSPFUncharacterized protein. (187 aa)
LOC101674940Uncharacterized protein. (187 aa)
LOC101676633Uncharacterized protein. (187 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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