STRINGSTRING
NFATC4 NFATC4 CREB3L1 CREB3L1 ARHGEF12 ARHGEF12 ROCK1 ROCK1 CREB3 CREB3 TRADD TRADD PTGER2 PTGER2 CALM3 CALM3 GNG8 GNG8 SOS2 SOS2 E2F3 E2F3 CREB5 CREB5 M3Y070_MUSPF M3Y070_MUSPF CREB3L3 CREB3L3 M3Y027_MUSPF M3Y027_MUSPF FADD FADD CCND1 CCND1 ADCY5 ADCY5 C7orf31 C7orf31 IL10RA IL10RA CX3CL1 CX3CL1 CALR CALR CGAS CGAS MAPK13 MAPK13 CREB3L2 CREB3L2 MAPK14 MAPK14 M3YNJ8_MUSPF M3YNJ8_MUSPF GNAI2 GNAI2 M3YPM9_MUSPF M3YPM9_MUSPF ELK1 ELK1 ROCK2 ROCK2 IL6 IL6 CRK CRK GNG3 GNG3 RHOA RHOA GRB2 GRB2 ATF2 ATF2 M3YRC5_MUSPF M3YRC5_MUSPF PTRHD1 PTRHD1 ADCY3 ADCY3 CDKN1A CDKN1A MAP2K6 MAP2K6 GNA13 GNA13 RHEBL1 RHEBL1 PRKCA PRKCA PIK3R1 PIK3R1 ADCY6 ADCY6 PTGER4 PTGER4 CCL2 CCL2 CCL5 CCL5 M3YU47_MUSPF M3YU47_MUSPF M3YU63_MUSPF M3YU63_MUSPF M3YU65_MUSPF M3YU65_MUSPF M3YU74_MUSPF M3YU74_MUSPF ADCY9 ADCY9 RPS6KB1 RPS6KB1 TSC2 TSC2 FASLG FASLG GNB2 GNB2 M3YWA8_MUSPF M3YWA8_MUSPF AKT3 AKT3 TRAF5 TRAF5 E2F2 E2F2 CDKN2A CDKN2A M3YX15_MUSPF M3YX15_MUSPF M3YX17_MUSPF M3YX17_MUSPF NFKBIA NFKBIA CASP9 CASP9 MTOR MTOR RUFY4 RUFY4 RAC1 RAC1 NFATC1 NFATC1 GNB3 GNB3 TNFRSF1A TNFRSF1A CHUK CHUK ITPR1 ITPR1 RAF1 RAF1 PIK3CA PIK3CA GNB4 GNB4 CXCL12 CXCL12 MDM2 MDM2 TBK1 TBK1 NFATC2 NFATC2 M3Z1J0_MUSPF M3Z1J0_MUSPF AKT2 AKT2 SRC SRC E2F1 E2F1 GNA12 GNA12 EGFR EGFR ADCY1 ADCY1 GNAI1 GNAI1 M3Z4Y0_MUSPF M3Z4Y0_MUSPF ENSMPUP00000018887 ENSMPUP00000018887 ENSMPUP00000018988 ENSMPUP00000018988 M3Z6U4_MUSPF M3Z6U4_MUSPF IFNG-2 IFNG-2 M3Z722_MUSPF M3Z722_MUSPF M3Z729_MUSPF M3Z729_MUSPF LOC101678496 LOC101678496 LOC101678795 LOC101678795 IFNB1 IFNB1 CALML5 CALML5 M3Z785_MUSPF M3Z785_MUSPF M3Z7C5_MUSPF M3Z7C5_MUSPF CCR5 CCR5 CCR3 CCR3 CCR1 CCR1 M3Z7V7_MUSPF M3Z7V7_MUSPF LOC101684074 LOC101684074 M3Z7W2_MUSPF M3Z7W2_MUSPF LOC101684365 LOC101684365 LOC101684645 LOC101684645 M3Z7X0_MUSPF M3Z7X0_MUSPF LOC101674940 LOC101674940 LOC101676633 LOC101676633 RPS6KB2 RPS6KB2 GNA11 GNA11 PPP3CC PPP3CC CRKL CRKL ARHGEF11 ARHGEF11 PPP3CB PPP3CB ITGAV ITGAV GNAO1 GNAO1 BAX BAX GNAI3 GNAI3 M3XVS8_MUSPF M3XVS8_MUSPF ADCY7 ADCY7 MAPK1 MAPK1 PXN PXN PRKACA PRKACA PTGER1 PTGER1 IRF3 IRF3 ITPR3 ITPR3 BAK1 BAK1 TAPBP TAPBP MAPK12 MAPK12 MAPK11 MAPK11 CXCR4 CXCR4 AKT1 AKT1 M3XSN5_MUSPF M3XSN5_MUSPF M3XSL7_MUSPF M3XSL7_MUSPF CDK4 CDK4 PTK2 PTK2 TAP1 TAP1 M3XS65_MUSPF M3XS65_MUSPF M3XRJ3_MUSPF M3XRJ3_MUSPF GNGT1 GNGT1 GNG11 GNG11 RB1 RB1 ADCY8 ADCY8 MYC MYC IL10RB IL10RB M3XPU6_MUSPF M3XPU6_MUSPF PTGER3 PTGER3 PTK2B PTK2B JAK1 JAK1 CREB1 CREB1 RIPK1 RIPK1 MAP2K1 MAP2K1 LPXN LPXN CALML4 CALML4 CASP8 CASP8 PLCB3 PLCB3 VEGFA VEGFA M3YMU3_MUSPF M3YMU3_MUSPF IKBKB IKBKB RAC2 RAC2 MAPK3 MAPK3 GNAQ GNAQ TSC1 TSC1 M3YLR8_MUSPF M3YLR8_MUSPF IL1R1 IL1R1 PRKCB PRKCB CALM2 CALM2 RELA RELA CTNNB1 CTNNB1 M3YJ13_MUSPF M3YJ13_MUSPF TNF TNF RAC3 RAC3 CASP3 CASP3 TRAF2 TRAF2 B2M B2M PTGS2 PTGS2 IL1B IL1B M3YH29_MUSPF M3YH29_MUSPF STAT3 STAT3 SOS1 SOS1 PDIA3 PDIA3 ITPR2 ITPR2 ATF6B ATF6B KRAS KRAS PRKCG PRKCG BCAR1 BCAR1 EIF4EBP1 EIF4EBP1 M3YEN4_MUSPF M3YEN4_MUSPF IKBKG IKBKG PPP3CA PPP3CA NFKB1 NFKB1 CXCL8 CXCL8 PIK3CB PIK3CB STING1 STING1 TP53 TP53 RHEB RHEB PLCB2 PLCB2 GSK3B GSK3B CDK6 CDK6 CALM1 CALM1 M3Y9K9_MUSPF M3Y9K9_MUSPF CALML6 CALML6 CREB3L4 CREB3L4 GNB5 GNB5 IL6R IL6R ARHGEF1 ARHGEF1 ADCY2 ADCY2 NFATC3 NFATC3 M3Y692_MUSPF M3Y692_MUSPF FAS FAS PLCB4 PLCB4 PLCB1 PLCB1 M3Y4E6_MUSPF M3Y4E6_MUSPF PIK3CD PIK3CD SP1 SP1 PDGFRA PDGFRA PRKACB PRKACB CSDE1 CSDE1 M3Y2Z6_MUSPF M3Y2Z6_MUSPF M3Z5X6_MUSPF M3Z5X6_MUSPF ADCY4 ADCY4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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NFATC4Nuclear factor of activated T cells 4. (831 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (520 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1544 aa)
ROCK1Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1252 aa)
CREB3cAMP responsive element binding protein 3. (353 aa)
TRADDTNFRSF1A associated via death domain. (314 aa)
PTGER2Prostaglandin E receptor 2; Belongs to the G-protein coupled receptor 1 family. (354 aa)
CALM3Calmodulin 3; Belongs to the calmodulin family. (151 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (76 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1281 aa)
E2F3E2F transcription factor 3. (340 aa)
CREB5cAMP responsive element binding protein 5. (275 aa)
M3Y070_MUSPFGuanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (473 aa)
M3Y027_MUSPFProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (216 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1018 aa)
C7orf31Chromosome 7 open reading frame 31. (589 aa)
IL10RAInterleukin 10 receptor subunit alpha. (611 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (461 aa)
CALRCalreticulin. (417 aa)
CGASCyclic GMP-AMP synthase. (526 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
M3YNJ8_MUSPFUncharacterized protein. (461 aa)
GNAI2G protein subunit alpha i2. (355 aa)
M3YPM9_MUSPFBZIP domain-containing protein. (351 aa)
ELK1ETS transcription factor ELK1. (435 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1389 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (210 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (76 aa)
RHOARas homolog family member A. (193 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
M3YRC5_MUSPFIg-like domain-containing protein; Belongs to the MHC class I family. (357 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
GNA13G protein subunit alpha 13. (284 aa)
RHEBL1RHEB like 1. (177 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (688 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
PTGER4Prostaglandin E receptor 4; Belongs to the G-protein coupled receptor 1 family. (489 aa)
CCL2C-C motif chemokine. (101 aa)
CCL5C-C motif chemokine. (91 aa)
M3YU47_MUSPFC-C motif chemokine. (93 aa)
M3YU63_MUSPFC-C motif chemokine. (107 aa)
M3YU65_MUSPFC-C motif chemokine. (93 aa)
M3YU74_MUSPFC-C motif chemokine. (92 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
TSC2TSC complex subunit 2. (1906 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (275 aa)
GNB2G protein subunit beta 2. (340 aa)
M3YWA8_MUSPFUncharacterized protein. (726 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
E2F2E2F transcription factor 2. (440 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (152 aa)
M3YX15_MUSPFUncharacterized protein. (161 aa)
M3YX17_MUSPFUncharacterized protein. (158 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (451 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2552 aa)
RUFY4RUN and FYVE domain containing 4. (544 aa)
RAC1Rac family small GTPase 1. (167 aa)
NFATC1Nuclear factor of activated T cells 1. (701 aa)
GNB3G protein subunit beta 3. (344 aa)
TNFRSF1ATNF receptor superfamily member 1A. (501 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2709 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (644 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
GNB4G protein subunit beta 4. (340 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (93 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (487 aa)
TBK1TANK-binding kinase 1. (729 aa)
NFATC2Nuclear factor of activated T cells 2. (912 aa)
M3Z1J0_MUSPFUncharacterized protein. (1151 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
SRCTyrosine-protein kinase. (536 aa)
E2F1E2F transcription factor 1. (354 aa)
GNA12G protein subunit alpha 12. (305 aa)
EGFRReceptor protein-tyrosine kinase. (1207 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1130 aa)
GNAI1G protein subunit alpha i1. (354 aa)
M3Z4Y0_MUSPFCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
ENSMPUP00000018887annotation not available (68 aa)
ENSMPUP00000018988annotation not available (68 aa)
M3Z6U4_MUSPFGuanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
IFNG-2Uncharacterized protein. (187 aa)
M3Z722_MUSPFUncharacterized protein. (187 aa)
M3Z729_MUSPFUncharacterized protein. (187 aa)
LOC101678496Uncharacterized protein. (187 aa)
LOC101678795Uncharacterized protein. (182 aa)
IFNB1Interferon beta. (186 aa)
CALML5Calmodulin like 5. (149 aa)
M3Z785_MUSPFUncharacterized protein; Belongs to the calmodulin family. (149 aa)
M3Z7C5_MUSPFG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (356 aa)
CCR5C-C motif chemokine receptor 5 (gene/pseudogene); Belongs to the G-protein coupled receptor 1 family. (352 aa)
CCR3C-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (360 aa)
CCR1C-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (360 aa)
M3Z7V7_MUSPFUncharacterized protein. (187 aa)
LOC101684074Uncharacterized protein. (187 aa)
M3Z7W2_MUSPFUncharacterized protein. (187 aa)
LOC101684365Uncharacterized protein. (187 aa)
LOC101684645Uncharacterized protein. (187 aa)
M3Z7X0_MUSPFUncharacterized protein. (187 aa)
LOC101674940Uncharacterized protein. (187 aa)
LOC101676633Uncharacterized protein. (187 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (479 aa)
GNA11G protein subunit alpha 11. (334 aa)
PPP3CCSerine/threonine-protein phosphatase. (525 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
ARHGEF11Rho guanine nucleotide exchange factor 11. (1536 aa)
PPP3CBSerine/threonine-protein phosphatase. (479 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1048 aa)
GNAO1G protein subunit alpha o1. (354 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
GNAI3G protein subunit alpha i3. (354 aa)
M3XVS8_MUSPFCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
MAPK1Mitogen-activated protein kinase. (333 aa)
PXNPaxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (590 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
PTGER1Prostaglandin E receptor 1. (338 aa)
IRF3Interferon regulatory factor 3. (421 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2609 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
TAPBPTAP binding protein. (462 aa)
MAPK12Mitogen-activated protein kinase. (287 aa)
MAPK11Mitogen-activated protein kinase. (434 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (353 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
M3XSN5_MUSPFUncharacterized protein; Belongs to the MHC class I family. (304 aa)
M3XSL7_MUSPFIg-like domain-containing protein; Belongs to the MHC class I family. (266 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (305 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1096 aa)
TAP1Transporter 1, ATP binding cassette subfamily B member. (686 aa)
M3XS65_MUSPFABC transporter domain-containing protein. (275 aa)
M3XRJ3_MUSPFUncharacterized protein. (182 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
RB1RB transcriptional corepressor 1. (948 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa)
MYCV-myc myelocytomatosis viral oncoprotein-like protein. (453 aa)
IL10RBInterleukin 10 receptor subunit beta. (359 aa)
M3XPU6_MUSPFIg-like domain-containing protein; Belongs to the MHC class I family. (368 aa)
PTGER3Prostaglandin E receptor 3. (389 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (646 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
LPXNLeupaxin; Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin- induced tyrosine phosphorylation of paxillin (PXN). (414 aa)
CALML4Calmodulin like 4. (153 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (484 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1233 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (398 aa)
M3YMU3_MUSPFMIR domain-containing protein. (78 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
RAC2Rac family small GTPase 2. (192 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (399 aa)
GNAQG protein subunit alpha q. (301 aa)
TSC1TSC complex subunit 1. (1165 aa)
M3YLR8_MUSPFRHD domain-containing protein. (249 aa)
IL1R1Interleukin 1 receptor type 1. (573 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (577 aa)
CALM2Calmodulin 2; Belongs to the calmodulin family. (149 aa)
RELARELA proto-oncogene, NF-kB subunit. (511 aa)
CTNNB1Catenin beta 1. (781 aa)
M3YJ13_MUSPFMHC_I-like_Ag-recog domain-containing protein; Belongs to the MHC class I family. (88 aa)
TNFTumor necrosis factor alpha; Belongs to the tumor necrosis factor family. (233 aa)
RAC3Rac family small GTPase 3. (160 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (569 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (128 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (168 aa)
M3YH29_MUSPFUncharacterized protein. (180 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1276 aa)
PDIA3Protein disulfide-isomerase. (505 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
ATF6BActivating transcription factor 6 beta. (707 aa)
KRASKRAS proto-oncogene, GTPase. (208 aa)
PRKCGNon-specific serine/threonine protein kinase. (569 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (867 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (118 aa)
M3YEN4_MUSPFBZIP domain-containing protein. (358 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (412 aa)
PPP3CASerine/threonine-protein phosphatase. (461 aa)
NFKB1Nuclear factor kappa B subunit 1. (971 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
STING1Transmembrane protein 173. (378 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (375 aa)
RHEBRas homolog, mTORC1 binding. (179 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1187 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (420 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (156 aa)
M3Y9K9_MUSPFIntegrin beta; Belongs to the integrin beta chain family. (645 aa)
CALML6Calmodulin like 6. (156 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (386 aa)
GNB5G protein subunit beta 5. (301 aa)
IL6RInterleukin 6 receptor. (436 aa)
ARHGEF1Rho guanine nucleotide exchange factor 1. (987 aa)
ADCY2Adenylate cyclase 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (880 aa)
NFATC3Nuclear factor of activated T cells 3. (1037 aa)
M3Y692_MUSPFUncharacterized protein. (362 aa)
FASFas cell surface death receptor. (311 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1096 aa)
M3Y4E6_MUSPFUncharacterized protein. (160 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
SP1Sp1 transcription factor. (787 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1087 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
CSDE1Cold shock domain containing E1. (784 aa)
M3Y2Z6_MUSPFUncharacterized protein. (189 aa)
M3Z5X6_MUSPFGuanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1105 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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