STRINGSTRING
CREBBP CREBBP FLCN FLCN MAP2K1 MAP2K1 GAB1 GAB1 EGLN3 EGLN3 AKT1 AKT1 PTPN11 PTPN11 MAPK1 MAPK1 BRAF BRAF CRKL CRKL PAK2 PAK2 PRCC PRCC PAK3 PAK3 M3XYN0_MUSPF M3XYN0_MUSPF TGFB2 TGFB2 ARNT ARNT M3Y027_MUSPF M3Y027_MUSPF RAP1A RAP1A SOS2 SOS2 EGLN1 EGLN1 M3Y2Z6_MUSPF M3Y2Z6_MUSPF CSDE1 CSDE1 CUL2 CUL2 PIK3CD PIK3CD PAK5 PAK5 HIF1A HIF1A MET MET TGFA TGFA PAK6 PAK6 ETS1 ETS1 PIK3CB PIK3CB ELOC ELOC KRAS KRAS SOS1 SOS1 M3YH29_MUSPF M3YH29_MUSPF EPAS1 EPAS1 RAPGEF1 RAPGEF1 MAPK3 MAPK3 VEGFA VEGFA BAD BAD M3YNJ8_MUSPF M3YNJ8_MUSPF PPP1R14B PPP1R14B PDGFB PDGFB ARAF ARAF CRK CRK SLC2A1 SLC2A1 TFE3 TFE3 GRB2 GRB2 M3YR72_MUSPF M3YR72_MUSPF CDKN1A CDKN1A PIK3R1 PIK3R1 ELOB ELOB ARNT2 ARNT2 FH FH M3YWA8_MUSPF M3YWA8_MUSPF AKT3 AKT3 PAK1 PAK1 M3YX33_MUSPF M3YX33_MUSPF EP300 EP300 RBX1 RBX1 M3Z0D5_MUSPF M3Z0D5_MUSPF RAF1 RAF1 PIK3CA PIK3CA RAP1B RAP1B TGFB1 TGFB1 EGLN2 EGLN2 AKT2 AKT2 PAK4 PAK4 HGF HGF JUN JUN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CREBBPCREB binding protein. (2442 aa)
FLCNUDENN FLCN/SMCR8-type domain-containing protein. (579 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
GAB1GRB2 associated binding protein 1. (648 aa)
EGLN3Egl-9 family hypoxia inducible factor 3. (239 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
MAPK1Mitogen-activated protein kinase. (333 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (715 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
PRCCProline rich mitotic checkpoint control factor. (356 aa)
PAK3P21 (RAC1) activated kinase 3. (583 aa)
M3XYN0_MUSPFUncharacterized protein. (192 aa)
TGFB2Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] (414 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (719 aa)
M3Y027_MUSPFProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
RAP1ARAP1A, member of RAS oncogene family. (188 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1281 aa)
EGLN1Fe2OG dioxygenase domain-containing protein. (296 aa)
M3Y2Z6_MUSPFUncharacterized protein. (189 aa)
CSDE1Cold shock domain containing E1. (784 aa)
CUL2Cullin 2; Belongs to the cullin family. (745 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (824 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1540 aa)
TGFATransforming growth factor alpha. (158 aa)
PAK6Non-specific serine/threonine protein kinase. (688 aa)
ETS1ETS proto-oncogene 1, transcription factor. (443 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
ELOCElongin C; Belongs to the SKP1 family. (112 aa)
KRASKRAS proto-oncogene, GTPase. (208 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1276 aa)
M3YH29_MUSPFUncharacterized protein. (180 aa)
EPAS1Endothelial PAS domain protein 1. (868 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1265 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (399 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (398 aa)
BADBCL2 associated agonist of cell death. (168 aa)
M3YNJ8_MUSPFUncharacterized protein. (461 aa)
PPP1R14BProtein phosphatase 1 regulatory inhibitor subunit 14B. (145 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (242 aa)
ARAFV-raf murine sarcoma 3611 viral oncoprotein-like protein. (606 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (480 aa)
TFE3Transcription factor binding to IGHM enhancer 3. (572 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
M3YR72_MUSPFUncharacterized protein. (542 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
ELOBElongin B. (118 aa)
ARNT2Aryl hydrocarbon receptor nuclear translocator 2. (728 aa)
FHFumarate hydratase. (504 aa)
M3YWA8_MUSPFUncharacterized protein. (726 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
M3YX33_MUSPFUncharacterized protein. (191 aa)
EP300E1A binding protein p300. (2425 aa)
RBX1Ring-box 1. (108 aa)
M3Z0D5_MUSPFUncharacterized protein. (219 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (644 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
RAP1BRAP1B, member of RAS oncogene family. (184 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
EGLN2Egl-9 family hypoxia inducible factor 2. (448 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PAK4Non-specific serine/threonine protein kinase. (592 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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