STRINGSTRING
TCF7L1 TCF7L1 MAP2K1 MAP2K1 GADD45A GADD45A MYC MYC TCF7L2 TCF7L2 M3XSG3_MUSPF M3XSG3_MUSPF AKT1 AKT1 BAK1 BAK1 MLH1 MLH1 MAPK1 MAPK1 BAX BAX BRAF BRAF CCND1 CCND1 M3Y027_MUSPF M3Y027_MUSPF DDB2 DDB2 SOS2 SOS2 ILK ILK POLK POLK EGFR EGFR AKT2 AKT2 PIK3CA PIK3CA RAF1 RAF1 M3YZX8_MUSPF M3YZX8_MUSPF CASP9 CASP9 AXIN1 AXIN1 AKT3 AKT3 M3YWA8_MUSPF M3YWA8_MUSPF PDPK1 PDPK1 ERBB2 ERBB2 PIK3R1 PIK3R1 AXIN2 AXIN2 CDKN1A CDKN1A GRB2 GRB2 ELK1 ELK1 ARAF ARAF PPP1R14B PPP1R14B M3YNJ8_MUSPF M3YNJ8_MUSPF BAD BAD APC APC MAPK3 MAPK3 M3YKK2_MUSPF M3YKK2_MUSPF M3YKJ5_MUSPF M3YKJ5_MUSPF CTNNB1 CTNNB1 M3YI89_MUSPF M3YI89_MUSPF M3YH29_MUSPF M3YH29_MUSPF SOS1 SOS1 KRAS KRAS TCF7 TCF7 FOXO3 FOXO3 CTNNA1 CTNNA1 PIK3CB PIK3CB TP53 TP53 LEF1 LEF1 CTNNA2 CTNNA2 M3YAW2_MUSPF M3YAW2_MUSPF EGF EGF GADD45G GADD45G GSK3B GSK3B APC2 APC2 CDH1 CDH1 M3Y696_MUSPF M3Y696_MUSPF GADD45B GADD45B PIK3CD PIK3CD CSDE1 CSDE1 M3Y2Z6_MUSPF M3Y2Z6_MUSPF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TCF7L1Transcription factor 7 like 1. (490 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
MYCV-myc myelocytomatosis viral oncoprotein-like protein. (453 aa)
TCF7L2Transcription factor 7 like 2. (514 aa)
M3XSG3_MUSPFCTNNB1_binding domain-containing protein. (169 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
MLH1MutL homolog 1. (758 aa)
MAPK1Mitogen-activated protein kinase. (333 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (715 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
M3Y027_MUSPFProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
DDB2Damage specific DNA binding protein 2. (426 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1281 aa)
ILKIntegrin linked kinase. (452 aa)
POLKDNA polymerase kappa. (870 aa)
EGFRReceptor protein-tyrosine kinase. (1207 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (644 aa)
M3YZX8_MUSPFUncharacterized protein. (144 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (451 aa)
AXIN1Axin 1. (862 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa)
M3YWA8_MUSPFUncharacterized protein. (726 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (531 aa)
ERBB2Receptor protein-tyrosine kinase. (1260 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
AXIN2Axin 2. (842 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
ELK1ETS transcription factor ELK1. (435 aa)
ARAFV-raf murine sarcoma 3611 viral oncoprotein-like protein. (606 aa)
PPP1R14BProtein phosphatase 1 regulatory inhibitor subunit 14B. (145 aa)
M3YNJ8_MUSPFUncharacterized protein. (461 aa)
BADBCL2 associated agonist of cell death. (168 aa)
APCAPC regulator of WNT signaling pathway. (2862 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (399 aa)
M3YKK2_MUSPFUncharacterized protein. (220 aa)
M3YKJ5_MUSPFUncharacterized protein. (247 aa)
CTNNB1Catenin beta 1. (781 aa)
M3YI89_MUSPFUncharacterized protein. (271 aa)
M3YH29_MUSPFUncharacterized protein. (180 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1276 aa)
KRASKRAS proto-oncogene, GTPase. (208 aa)
TCF7Transcription factor 7. (339 aa)
FOXO3Forkhead box O3. (671 aa)
CTNNA1Catenin alpha 1. (930 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (375 aa)
LEF1Lymphoid enhancer binding factor 1. (400 aa)
CTNNA2Catenin alpha 2. (521 aa)
M3YAW2_MUSPFUncharacterized protein. (429 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (420 aa)
APC2APC regulator of WNT signaling pathway 2. (2481 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (885 aa)
M3Y696_MUSPFUncharacterized protein. (492 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
CSDE1Cold shock domain containing E1. (784 aa)
M3Y2Z6_MUSPFUncharacterized protein. (189 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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