STRINGSTRING
CREB3L2 CREB3L2 NFKBIA NFKBIA CASP9 CASP9 EP300 EP300 MTOR MTOR BCL2 BCL2 CHUK CHUK NKX2-3 NKX2-3 M3YZX8_MUSPF M3YZX8_MUSPF RAF1 RAF1 PIK3CA PIK3CA MDM2 MDM2 MMP9 MMP9 AKT2 AKT2 E2F1 E2F1 PDGFA PDGFA EGFR EGFR PPP1R14B PPP1R14B ZEB1 ZEB1 M3YNJ8_MUSPF M3YNJ8_MUSPF BAD BAD IKBKB IKBKB MAPK3 MAPK3 HSP90AB1 HSP90AB1 IL1R2 IL1R2 HSP90B1 HSP90B1 IGF1 IGF1 RELA RELA CTNNB1 CTNNB1 IGF1R IGF1R M3YH29_MUSPF M3YH29_MUSPF AR AR SOS1 SOS1 KRAS KRAS TCF7 TCF7 M3YEN4_MUSPF M3YEN4_MUSPF IKBKG IKBKG M3YEF8_MUSPF M3YEF8_MUSPF FGFR1 FGFR1 NFKB1 NFKB1 PIK3CB PIK3CB TP53 TP53 LEF1 LEF1 CCNE2 CCNE2 TMPRSS2 TMPRSS2 SPINT1 SPINT1 TCF7L1 TCF7L1 EGF EGF ERG ERG GSK3B GSK3B CCNE1 CCNE1 M3Y9E6_MUSPF M3Y9E6_MUSPF CREB3L4 CREB3L4 TGFA TGFA M3Y672_MUSPF M3Y672_MUSPF LOC101688701 LOC101688701 MMP12 MMP12 PDGFD PDGFD PIK3CD PIK3CD PDGFRA PDGFRA CSDE1 CSDE1 PLAT PLAT PDGFC PDGFC M3Y2Z6_MUSPF M3Y2Z6_MUSPF CREB3L1 CREB3L1 INS INS CREB3 CREB3 SRD5A2 SRD5A2 SOS2 SOS2 E2F3 E2F3 CREB5 CREB5 CREB3L3 CREB3L3 M3Y027_MUSPF M3Y027_MUSPF CCND1 CCND1 M3XY45_MUSPF M3XY45_MUSPF M3XY39_MUSPF M3XY39_MUSPF INSRR INSRR NKX3-1 NKX3-1 BRAF BRAF PLAU PLAU ETV5 ETV5 MAPK1 MAPK1 FGFR2 FGFR2 HSP90AA1 HSP90AA1 AKT1 AKT1 M3XSM2_MUSPF M3XSM2_MUSPF M3XSG3_MUSPF M3XSG3_MUSPF TCF7L2 TCF7L2 RB1 RB1 CDK2 CDK2 CREB1 CREB1 MAP2K1 MAP2K1 E2F2 E2F2 AKT3 AKT3 M3YWA8_MUSPF M3YWA8_MUSPF PDPK1 PDPK1 CREBBP CREBBP ERBB2 ERBB2 PIK3R1 PIK3R1 CDKN1A CDKN1A PDGFRB PDGFRB GRB2 GRB2 M3YPM9_MUSPF M3YPM9_MUSPF ARAF ARAF PDGFB PDGFB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (451 aa)
EP300E1A binding protein p300. (2425 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2552 aa)
BCL2BCL2 apoptosis regulator. (207 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
NKX2-3NK2 homeobox 3. (281 aa)
M3YZX8_MUSPFUncharacterized protein. (144 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (644 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (487 aa)
MMP9Matrix metallopeptidase 9. (704 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
E2F1E2F transcription factor 1. (354 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
EGFRReceptor protein-tyrosine kinase. (1207 aa)
PPP1R14BProtein phosphatase 1 regulatory inhibitor subunit 14B. (145 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1109 aa)
M3YNJ8_MUSPFUncharacterized protein. (461 aa)
BADBCL2 associated agonist of cell death. (168 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (399 aa)
HSP90AB1Heat shock protein 90 alpha family class B member 1. (724 aa)
IL1R2Interleukin 1 receptor type 2. (414 aa)
HSP90B1Heat shock protein 90 beta family member 1. (803 aa)
IGF1Insulin like growth factor 1. (153 aa)
RELARELA proto-oncogene, NF-kB subunit. (511 aa)
CTNNB1Catenin beta 1. (781 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
M3YH29_MUSPFUncharacterized protein. (180 aa)
ARAndrogen receptor. (892 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1276 aa)
KRASKRAS proto-oncogene, GTPase. (208 aa)
TCF7Transcription factor 7. (339 aa)
M3YEN4_MUSPFBZIP domain-containing protein. (358 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (412 aa)
M3YEF8_MUSPFFOXO-TAD domain-containing protein. (399 aa)
FGFR1Fibroblast growth factor receptor. (856 aa)
NFKB1Nuclear factor kappa B subunit 1. (971 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (375 aa)
LEF1Lymphoid enhancer binding factor 1. (400 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
TMPRSS2Transmembrane serine protease 2; Belongs to the peptidase S1 family. (531 aa)
SPINT1Serine peptidase inhibitor, Kunitz type 1. (521 aa)
TCF7L1Transcription factor 7 like 1. (490 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
ERGETS transcription factor ERG. (479 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (420 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (410 aa)
M3Y9E6_MUSPFUncharacterized protein. (203 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (386 aa)
TGFATransforming growth factor alpha. (158 aa)
M3Y672_MUSPFUncharacterized protein. (100 aa)
LOC101688701ZnMc domain-containing protein. (476 aa)
MMP12Matrix metallopeptidase 12. (493 aa)
PDGFDPlatelet derived growth factor D. (364 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1087 aa)
CSDE1Cold shock domain containing E1. (784 aa)
PLATPlasminogen activator, tissue type. (639 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
M3Y2Z6_MUSPFUncharacterized protein. (189 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (520 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (109 aa)
CREB3cAMP responsive element binding protein 3. (353 aa)
SRD5A23-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (254 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1281 aa)
E2F3E2F transcription factor 3. (340 aa)
CREB5cAMP responsive element binding protein 5. (275 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (473 aa)
M3Y027_MUSPFProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
M3XY45_MUSPFUncharacterized protein; Belongs to the GST superfamily. (193 aa)
M3XY39_MUSPFUncharacterized protein; Belongs to the GST superfamily. (210 aa)
INSRRTyrosine-protein kinase receptor. (1358 aa)
NKX3-1NK3 homeobox 1. (231 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (715 aa)
PLAUPlasminogen activator, urokinase. (432 aa)
ETV5ETS variant 5. (608 aa)
MAPK1Mitogen-activated protein kinase. (333 aa)
FGFR2Fibroblast growth factor receptor. (842 aa)
HSP90AA1HATPase_c domain-containing protein. (679 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
M3XSM2_MUSPFUncharacterized protein. (164 aa)
M3XSG3_MUSPFCTNNB1_binding domain-containing protein. (169 aa)
TCF7L2Transcription factor 7 like 2. (514 aa)
RB1RB transcriptional corepressor 1. (948 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (334 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
E2F2E2F transcription factor 2. (440 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa)
M3YWA8_MUSPFUncharacterized protein. (726 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (531 aa)
CREBBPCREB binding protein. (2442 aa)
ERBB2Receptor protein-tyrosine kinase. (1260 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1137 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
M3YPM9_MUSPFBZIP domain-containing protein. (351 aa)
ARAFV-raf murine sarcoma 3611 viral oncoprotein-like protein. (606 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (242 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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